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Metabolomics reveals the role of PPAR alpha in Tripterygium Wilfordii-induced liver injury 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2022, 卷号: 289, 页码: 16
作者:  Dai, Manyun;  Peng, Wan;  Zhang, Ting;  Zhao, Qi;  Ma, Xiaofang;  Cheng, Yan;  Wang, Chunyan;  Li, Fei
收藏  |  浏览/下载：303/0  |  提交时间：2022/07/15
Tripterygium wilfordii  Liver injury  PPAR alpha  IL6-STAT3  Metabolomics  
PXR mediates mifepristone-induced hepatomegaly in mice 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 1, 页码: 146-156
作者:  Yao,Xin-peng;  Jiao,Ting-ying;  Jiang,Yi-ming;  Fan,Shi-cheng;  Zhao,Ying-yuan;  Yang,Xiao;  Gao,Yue;  Li,Fei;  Zhou,Yan-ying;  Chen,Pan-pan;  Huang,Min;  Bi,Hui-chang
收藏  |  浏览/下载：101/0  |  提交时间：2022/04/02
mifepristone  hepatomegaly  pregnane X receptor (PXR)  yes-associated protein (YAP)  
Discovery of novel coffee diterpenoids with inhibitions on Ca(v)3.1 low voltage-gated Ca2+ channel 期刊论文
FOOD CHEMISTRY, 2022, 卷号: 376, 页码: 131923
作者:  Hu,Guilin;  Dong,Ding;  Du,Shuzong;  Peng,Xingrong;  Wu,Mingkun;  Shi,Qiangqiang;  Hu,Kun;  Hong,Defu;  Wang,Xiaoyuan;  Zhou,Lin;  Nian,Yin;  Qiu,Minghua
浏览  |  Adobe PDF(4722Kb)  |  收藏  |  浏览/下载：176/46  |  提交时间：2022/04/02
Coffea arabica L  Roasted coffee  Coffee diterpenoid  Cafestol  Kahweol  T-type Ca2+ channels  Ca(v)3.1 low voltage-gated Ca2+ channel  Ca(v)3.1 inhibitors  CALCIUM-CHANNELS  CAFESTOL  KAHWEOL  PHYSIOLOGY  ESTERS  NOMENCLATURE  PHARMACOLOGY  APOPTOSIS  FURANS  
Small molecule QF84139 ameliorates cardiac hypertrophy via activating the AMPK signaling pathway 期刊论文
ACTA PHARMACOLOGICA SINICA, 2022, 卷号: 43, 期号: 3, 页码: 588-601
作者:  Li,Xu-xia;  Zhang,Peng;  Yang,Yang;  Wang,Jing-jing;  Zheng,Yan-jun;  Tan,Ji-liang;  Liu,Shen-yan;  Yan,Yong-ming;  Zhang,You-yi;  Cheng,Yong-xian;  Yang,Huang-tian
收藏  |  浏览/下载：80/0  |  提交时间：2022/04/02
cardiac hypertrophy  pyrazine derivative  QF84139  phenylephrine  transverse aortic constriction  AMPK signaling pathway  PROTEIN-KINASE  MAMMALIAN TARGET  OVERLOAD  METFORMIN  MACROPHAGES  MECHANISMS  MEDICINE  ALPHA  CELLS  MODEL  
Moringa oleifera seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism 期刊论文
PHARMACEUTICAL BIOLOGY, 2022, 卷号: 60, 期号: 1, 页码: 810-824
作者:  Liu, Wei-Liang;  Wu, Bai-Fen;  Shang, Jian-Hua;  Wang, Xue-Feng;  Zhao, Yun-Li;  Huang, Ai-Xiang
浏览  |  Adobe PDF(4141Kb)  |  收藏  |  浏览/下载：30/5  |  提交时间：2024/04/30
Sedative-hypnotic  Cl- influx  GABA(A) receptors  GABA(A)-ergic systems  BLOOD-BRAIN-BARRIER  GABA(A) RECEPTORS  INSOMNIA  MODULATION  PHYSIOLOGY  FLAVONOIDS  TOXICITY  ANXIETY  NEURONS  DISEASE  
Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance 期刊论文
JOURNAL OF ENDOCRINOLOGY, 2022, 卷号: 254, 期号: 3, 页码: 151-165
作者:  Qin, Wanying;  Zhang, Ting;  Ge, Mingxia;  Zhou, Huimin;  Xu, Yuhui;  Mu, Rongfang;  Huang, Chaoguang;  Liu, Daowei;  Huang, Bangrui;  Wang, Qian;  Kong, Qinghua;  Kong, Qingpeng;  Li, Fei;  Xiong, Wenyong
浏览  |  Adobe PDF(9525Kb)  |  收藏  |  浏览/下载：30/8  |  提交时间：2024/04/30
RACK1  bile acid  glucose metabolism  insulin sensitivity  ENDOPLASMIC-RETICULUM STRESS  C-KINASE 1  HEPATOCELLULAR-CARCINOMA  STEROL 12-ALPHA-HYDROXYLASE  DOWN-REGULATION  ER STRESS  KAPPA-B  RECEPTOR  ACTIVATION  GROWTH  
Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin 期刊论文
MOLECULAR & CELLULAR TOXICOLOGY, 2022, 卷号: 18, 期号: 3, 页码: 359-369
作者:  Zhu, Xiang;  Na, Xin;  Zeng, Yueqin;  Xu, Yangantai;  Chai, Dongya;  Yang, Huanzhi;  Miao, Jingqian;  Zhang, Yuan;  Yang, Fenghua;  Wang, Yuehu;  Zhou, Yiping
浏览  |  Adobe PDF(1889Kb)  |  收藏  |  浏览/下载：31/7  |  提交时间：2024/04/30
Polyphyllin I  Chemosensitization  Doxorubicin  Immunotoxicity  Hemolysis  BREAST-CANCER CELLS  SAPONIN  INHIBITION  RESISTANCE  CISPLATIN  
Synthesis and biological evaluation of (+)-paeoveitol derivatives as novel antidepressants 期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2022, 卷号: 31, 期号: 11, 页码: 2045-2057
作者:  Li, Tian-Ze;  Huang, Xiao-Yan;  Sun, Jin-Jin;  Geng, Chang-An;  Zhang, Xue-Mei;  Chen, Ji-Jun
浏览  |  Adobe PDF(1234Kb)  |  收藏  |  浏览/下载：39/9  |  提交时间：2024/04/30
(+)-Paeoveitol derivatives  Antidepressant  Forced swimming test  Monoamine neurotransmitter  
Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RAR alpha-PPAR gamma-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice 期刊论文
NUTRIENTS, 2022, 卷号: 14, 期号: 12, 页码: 2411
作者:  Zhao, Zhuohui;  Deng, Zhen-Tao;  Huang, Suling;  Ning, Mengmeng;  Feng, Ying;  Shen, Yu;  Zhao, Qin-Shi;  Leng, Ying
Adobe PDF(6451Kb)  |  收藏  |  浏览/下载：44/11  |  提交时间：2024/04/30
Alisol B  non-alcoholic steatohepatitis  RAR alpha  CD36  FATTY LIVER  HEPATIC STEATOSIS  RECEPTOR  ORIENTALE  LIPOPROTEINS  23-ACETATE  AGONIST  CD36  
Synthesis and biological evaluation of paeoveitol D derivatives as new melatonin receptor agonists with antidepressant activities 期刊论文
RSC MEDICINAL CHEMISTRY, 2022, 卷号: 13, 期号: 10, 页码: 1212-1224
作者:  Li, Tian-Ze;  Hu, Jing;  Sun, Jin-Jin;  Huang, Xiao-Yan;  Geng, Chang-An;  Liu, Shu-Bai;  Zhang, Xue-Mei;  Chen, Ji-Jun
Adobe PDF(932Kb)  |  收藏  |  浏览/下载：40/9  |  提交时间：2024/04/30
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