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Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects 期刊论文
CHEMISTRY & BIODIVERSITY, 2021, 卷号: 18, 期号: 1
Authors:  Yan,Huan;  Li,Xiang;  Ni,Wei;  Zhao,Qing;  Leng,Ying;  Liu,Hai-Yang
Favorite  |  View/Download:6/0  |  Submit date:2022/04/02
Cyclocarya paliurus  dammarane-type triterpenoid saponins  11β  -HSD1 enzyme  inhibitory activity  ANTIOXIDANT ACTIVITIES  CHEMICAL-CONSTITUENTS  DEHYDROGENASE TYPE-1  TRITERPENOIDS  POLYSACCHARIDE  SAPONINS  
Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway 期刊论文
MOLECULAR METABOLISM, 2020
Authors:  Liu, Siwen;  Huang, Suling;  Wu, Xingde;  Feng, Ying;  Shen, Yu;  Zhao, Qin-shi;  Leng, Ying
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Synthesis of selective 11 beta-HSD1 inhibitors based on dammarane scaffold 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 135, 页码: 324-338
Authors:  Shao, Li-Dong;  Bao, Ying;  Shen, Yu;  Su, Jia;  Leng, Ying;  Zhao, Qin-Shi
Adobe PDF(1336Kb)  |  Favorite  |  View/Download:216/27  |  Submit date:2017/07/31
11 Beta-hsd1 Inhibitor  Hupehenols  Dammarane  Sar  
呋喃卡山烷二萜衍生物及其药物组合物和其在制药中的应用 专利
申请日期: 2017-01-13, 公开日期: 2017-06-09
Inventors:  赵勤实;  冷颖;  吴兴德;  黄素玲;  苏佳;  邵立东;  彭丽艳
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16-nor Limonoids from Harrisonia perforata as promising selective 11 beta-HSD1 inhibitors 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6, 页码: 1
Authors:  Xiao-HuiYan;  Yi, Ping;  Cao, Pei;  Yang, Shi-Ying;  Fang, Xin;  Zhang, Yu;  Wu, Bin;  Leng, Ying;  Di, Ying-Tong;  Lv, Yang;  Hao, Xiao-Jiang
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Synthesis of hupehenols A, B, and E from protopanaxadiol 期刊论文
RSC ADVANCES, 2016, 卷号: 6, 期号: 42, 页码: 35792-35803
Authors:  Shao, Li-Dong;  Xu, Jun;  Li, Xiao-Nian;  Zhang, Zhi-Jun;  Shi, Xin;  Ren, Jian;  He, Juan;  Zhao, Yu;  Leng, Ying;  Xia, Chengfeng;  Zhao, Qin-Shi
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Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2015, 卷号: 78, 期号: 2, 页码: 330-334
Authors:  Chen, Xuan-Qin;  Shao, Li-Dong;  Pal, Mahesh;  Shen, Yu;  Cheng, Xiao;  Xu, Gang;  Peng, Li-Yan;  Wang, Kou;  Pan, Zheng-Hong;  Li, Ming-Ming;  Leng, Ying;  He, Juan;  Zhao, Qin-Shi;  He,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Yunnan,Peoples R China.;  hejuan@mail.kib.ac.cn;  qinshizhao@mail.kib.ac.cn
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Further cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca 期刊论文
PHYTOCHEMISTRY LETTERS, 2014, 卷号: 7, 页码: 52-56
Authors:  Mpetga, James D. Simo;  He, Hong-Ping;  Hao, Xiao-Jiang;  Leng, Ying;  Tane, Pierre
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Caloncoba Glauca  Cycloartane  Friedelane  11 Beta-hydroxysteroid Dehydrogenase  
Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana. 期刊论文
Natural products and bioprospecting, 2014, 卷号: 4, 期号: 3, 页码: 149-55
Authors:  Yin, Xia;  Feng, Tao;  Li, Zheng-Hui;  Leng, Ying;  Liu, Ji-Kai
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Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11 beta-HSD1 inhibitors: Potential impact in diabetes 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 65, 页码: 403-414
Authors:  Deng, Xu;  Shen, Yu;  Yang, Jing;  He, Juan;  Zhao, Yu;  Peng, Li-Yan;  Leng, Ying;  Zhao, Qin-Shi
View  |  Adobe PDF(1215Kb)  |  Favorite  |  View/Download:358/139  |  Submit date:2013/10/16
Ent-kaurene Diterpenoids  Structure-activity Relationship Studies  Selective 11 Beta-hsd1 Inhibitors  Urea Derivatives  Diabetes