Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects

doi:10.1002/cbdv.202000772

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	Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects
	Yan,Huan ; Li,Xiang ; Ni,Wei ; Zhao,Qing ; Leng,Ying ; Liu,Hai-Yang
	2021
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	18 期号:1
摘要	Two new dammarane-type triterpenoid saponins, 3 beta-(alpha-l-arabinopyranosyloxy)-24,25-dihydroxydammar-20-en-12 alpha-yl 6-deoxy-beta-d-glucopyranoside (1) and (24R)-3 beta-[(4-O-acetyl-alpha-l-arabinopyranosyl)oxy]-25-hydroxy-20,24-epoxydammaran-12 beta-yl 6-deoxy-beta-d-glucopyranoside (2), and fourteen known triterpenoids were isolated from the 70 % MeOH extract of the leaves of Cyclocarya paliurus. Their structures were established based on analyses of spectroscopic data. All compounds were tested for their inhibitory activities against the 11 beta-HSD1 enzyme. Hederagenin (13) exhibited moderate inhibitory effect for mouse 11 beta-HSD1 with an IC50 value of 0.16 +/- 0.04 mu M.
关键词	Cyclocarya paliurus dammarane-type triterpenoid saponins 11β -HSD1 enzyme inhibitory activity ANTIOXIDANT ACTIVITIES CHEMICAL-CONSTITUENTS DEHYDROGENASE TYPE-1 TRITERPENOIDS POLYSACCHARIDE SAPONINS
DOI	10.1002/cbdv.202000772
WOS记录号	WOS:000602674800001
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73468
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Yunnan Univ Chinese Med, Kunming 650500, Yunnan, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Yan,Huan,Li,Xiang,Ni,Wei,et al. Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects[J]. CHEMISTRY & BIODIVERSITY,2021,18(1).
APA	Yan,Huan,Li,Xiang,Ni,Wei,Zhao,Qing,Leng,Ying,&Liu,Hai-Yang.(2021).Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects.CHEMISTRY & BIODIVERSITY,18(1).
MLA	Yan,Huan,et al."Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects".CHEMISTRY & BIODIVERSITY 18.1(2021).

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