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The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP)1 期刊论文
出版物, 3111, 期号: 0, 页码: 1-42
作者:  C Pergola;  J Gerstmeier;  B Monch;  B Çaliskan;  S Luderer;  C Weinige;  D Barz;  J Maczewsky;  S Pace;  A Rossi;  L Sautebin;  E Banoglu;  O Werz
Adobe PDF(1387Kb)  |  收藏  |  浏览/下载：493/1  |  提交时间：2017/07/24
The Tyrosine Kinase Inhibitor Bafetinib Inhibits PAR2-induced Activation of TRPV4 In Vitro and Pain In Vivo1 期刊论文
出版物, 2111, 页码: 1-44
作者:  1M S Grace;  T Lieu;  B Darby;  F C Abogadie;  N Veldhuis N W Bunnett;  P McIntyre
Adobe PDF(1611Kb)  |  收藏  |  浏览/下载：349/1  |  提交时间：2017/07/24
Transient Receptor Potential Ion Channel  Trpv4  Protease Activated Receptor  Par2  Pain  Tyrosine Kinase  Bafetinib  
Metabolomics Reveals Gut Microbiota Contribute to PPARα Deficiency-Induced Alcoholic Liver Injury 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2023, 卷号: 22, 期号: 7, 页码: 2327-2338
作者:  Zhang,Ting;  Bao,Lijuan;  Zhao,Qi;  Wu,Zhanxuan E. E.;  Dai,Manyun;  Rao,Qianru;  Li,Fei
浏览  |  Adobe PDF(9616Kb)  |  收藏  |  浏览/下载：186/34  |  提交时间：2024/07/10
metabolomics  alcohol-induced liver injury  gut microbiota  PPAR & alpha  AROMATIC-AMINO-ACIDS  LIPID-METABOLISM  FED MICE  MODULATION  DISEASE  AXIS  OLEOYLETHANOLAMIDE  AGONIST  OBESITY  DEATH  
Metabolomics Reveals Gut Microbiota Contribute to PPAR & alpha; Deficiency-Induced Alcoholic Liver Injury 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2023
作者:  Zhang,Ting;  Bao,Lijuan;  Zhao,Qi;  Wu,Zhanxuan E. E.;  Dai,Manyun;  Rao,Qianru;  Li,Fei
浏览  |  Adobe PDF(9616Kb)  |  收藏  |  浏览/下载：211/37  |  提交时间：2024/07/10
metabolomics  alcohol-induced liver injury  gut microbiota  PPAR & alpha  AROMATIC-AMINO-ACIDS  LIPID-METABOLISM  FED MICE  MODULATION  DISEASE  AXIS  OLEOYLETHANOLAMIDE  AGONIST  OBESITY  DEATH  
Tripterygium wilfordii protects against an animal model of autoimmune hepatitis 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 309, 页码: 116365
作者:  Zhang,Ting;  Rao,Qianru;  Dai,Manyun;  Zhao,Qi;  Li,Fei
浏览  |  Adobe PDF(13950Kb)  |  收藏  |  浏览/下载：175/40  |  提交时间：2024/07/25
Tripterygium wilfordii tablets  Celastrol  Concanavalin A  Autophagy  TFEB  PXR  PREGNANE-X-RECEPTOR  CHOLESTATIC LIVER-INJURY  CELASTROL PROTECTS  AUTOPHAGY  OBESITY  DYSFUNCTION  DOMAIN  
Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice 期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 1829
作者:  Zhao,Qi;  Dai,Man-Yun;  Huang,Ruo-Yue;  Duan,Jing-Yi;  Zhang,Ting;  Bao,Wei-Min;  Zhang,Jing-Yi;  Gui,Shao-Qiang;  Xia,Shu-Min;  Dai,Cong-Ting;  Tang,Ying-Mei;  Gonzalez,Frank J. J.;  Li,Fei
浏览  |  Adobe PDF(5393Kb)  |  收藏  |  浏览/下载：247/45  |  提交时间：2024/05/09
FATTY LIVER-DISEASE  INDUCED CHOLESTASIS  STELLATE CELLS  PROBIOTICS  PROTECTS  INFLAMMATION  APOPTOSIS  OBESITY  AXIS  
Prebiotic-Based Nanoamorphous Atorvastatin Attenuates Nonalcoholic Fatty Liver Disease by Retrieving Gut and Liver Health 期刊论文
SMALL STRUCTURES, 2023, 页码: 2200312
作者:  Cui,Jin-Jin;  Li,Rui;  Ma,Xiao-Lei;  Yu,Hao-Yang;  Luo,Zhi-Gang;  Du,Peng;  Ren,Ling;  Ding,Xiao;  Guo,Xiu-Ping;  Zheng,Wen-Sheng;  Jiang,Jian-Dong;  Che,Yongsheng;  Wang,Lu-Lu
浏览  |  Adobe PDF(26415Kb)  |  收藏  |  浏览/下载：239/48  |  提交时间：2024/07/30
atorvastatin  gut flora  nanoamorphous  nonalcoholic fatty liver disease  prebiotics  SOLID DISPERSIONS  STATIN USE  EFFICACY  STEATOHEPATITIS  FORMULATION  SAFETY  ABSORPTION  ACTIVATION  MICROBIOTA  CIRRHOSIS  
Identification of 3H-benzo[b] [1,4] diazepine derivatives as PPARα agonists by in silico studies and biochemical evaluation 期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023, 页码: 2256867
作者:  Li,Yue;  Lv,Mengjia;  Shen,Meiling;  Gu,Xi;  Zhang,Li;  Liu,Xingyong;  Chen,Jing;  Gong,Likun;  Zuo,Zhili
浏览  |  Adobe PDF(3338Kb)  |  收藏  |  浏览/下载：174/29  |  提交时间：2024/07/31
NAFLD  PPAR alpha agonist  virtual screening  biochemical evaluation  FATTY-ACID OXIDATION  GROMACS  
泽泻醇Alisols A/B的结构修饰与石松生物碱Huperserratines A/B的全合成研究 学位论文
: 中国科学院大学, 2022
作者:  邓振涛
Microsoft Word(17904Kb)  |  收藏  |  浏览/下载：157/0  |  提交时间：2024/05/14
泽泻醇 B，NAFLD，石松生物碱，Huperserratine A，全合成  Alisol B, NAFLD, Lycopodium alkaloids, Huperserratine A, Total synthesis  
Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RAR alpha-PPAR gamma-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice 期刊论文
NUTRIENTS, 2022, 卷号: 14, 期号: 12, 页码: 2411
作者:  Zhao, Zhuohui;  Deng, Zhen-Tao;  Huang, Suling;  Ning, Mengmeng;  Feng, Ying;  Shen, Yu;  Zhao, Qin-Shi;  Leng, Ying
浏览  |  Adobe PDF(6451Kb)  |  收藏  |  浏览/下载：264/54  |  提交时间：2024/04/30
Alisol B  non-alcoholic steatohepatitis  RAR alpha  CD36  FATTY LIVER  HEPATIC STEATOSIS  RECEPTOR  ORIENTALE  LIPOPROTEINS  23-ACETATE  AGONIST  CD36