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ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells1 期刊论文
出版物, 3111, 期号: 0, 页码: 1-35
Authors:  Jingru Li;  Yicheng Chen;  Jiali Wan;  Xin Liu;  Chunrong Yu;  Wenhua Li
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Abt-263  Sorafenib  Combination Therapy  Cancer  
Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase-9 through modulation of NF-B and AP-1 activity in human liver cancer cells lines 期刊论文
出版物, 3111, 期号: 0, 页码: 1—28
Authors:  Ming-Ju Hsieh;  Chiao-Wen Lin;  Shun-Fa Yang;  Mu-Kuan Chen;  Hui-Ling Chiou
Adobe PDF(1320Kb)  |  Favorite  |  View/Download:197/1  |  Submit date:2017/07/24
Glabridin  Migration  Invasion  Matrix Metalloproteinase-9  Hepatoma  
New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217) 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 2, 页码: 1487
Authors:  Li,Sheng;  Han,Ling-Ling;  Huang,Ke-Pu;  Ma,Ye-Han;  Guo,Ling-Li;  Guo,Yarong;  Ran,Xiaoqian;  Yao,Yong-Gang;  Hao,Xiao-Jiang;  Luo,Rongcan;  Zhang,Yu
View  |  Adobe PDF(5266Kb)  |  Favorite  |  View/Download:29/9  |  Submit date:2024/05/09
Tabernaemontana crassa  monoterpenoid indole alkaloids  A beta 42  phospho-tau (Thr217)  Alzheimer's disease  ALZHEIMERS-DISEASE  BISINDOLE ALKALOIDS  CDK5  GEMFIBROZIL  PREVENTION  ALGORITHM  AUTOPHAGY  MODELS  PLANTS  MOUSE  
Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 2, 页码: 1088
Authors:  Yan,Ying;  Zhou,Qi;  Ran,Xiaoqian;  Lu,Qingyun;  Zhang,Cuishan;  Peng,Mingyou;  Tang,Lei;  Luo,Rongcan;  Di,Yingtong;  Hao,Xiaojiang
View  |  Adobe PDF(11343Kb)  |  Favorite  |  View/Download:28/6  |  Submit date:2024/05/09
euphjatrophane  Euphorbia peplus  jatrophane diterpenoid  autophagy  Tau pathology  UBIQUITIN-PROTEASOME SYSTEM  MULTIDRUG-RESISTANCE  BIOLOGICAL-ACTIVITY  ALZHEIMERS-DISEASE  MODULATORS  CELLS  
蕊木和奶子藤中生物碱类化学成分及其生物活性评价 学位论文
: 中国科学院大学, 2022
Authors:  陈谌
Adobe PDF(17478Kb)  |  Favorite  |  View/Download:135/0  |  Submit date:2024/05/14
夹竹桃科  Apocynaceae  蕊木  Kopsia arborea  奶子藤  Bousigonia mekongensis  单萜吲哚生物碱  Monoterterpene indole alkaloids  生物活性  Biological activity  
20-去氧巨大戟醇酯衍生物合成及其构效关系研究 学位论文
: 中国科学院大学, 2022
Authors:  张翠珊
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20-去氧巨大戟醇酯,自噬,结构修饰,构效关系  20-Deoxyingenane esters, Autophagy, Structural modification, SAR  
南欧大戟中大戟二萜类成分及其自噬相关活性评价 学位论文
: 中国科学院大学, 2022
Authors:  李盈瑶
Adobe PDF(4112Kb)  |  Favorite  |  View/Download:13/0  |  Submit date:2024/05/14
南欧大戟  Euphorbia peplus  大戟二萜  Euphorbia diterpenoids  自噬-溶酶体  autophagy-lysosomal  
新型天然铁死亡诱导剂的筛选及作用机制研究 学位论文
: 中国科学院大学, 2022
Authors:  赵越勤
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肿瘤,天然产物,铁死亡,溶酶体,p53  Cancer, Nature products, Ferroptosis, Lysosome, p53  
Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance 期刊论文
JOURNAL OF ENDOCRINOLOGY, 2022, 卷号: 254, 期号: 3, 页码: 151-165
Authors:  Qin, Wanying;  Zhang, Ting;  Ge, Mingxia;  Zhou, Huimin;  Xu, Yuhui;  Mu, Rongfang;  Huang, Chaoguang;  Liu, Daowei;  Huang, Bangrui;  Wang, Qian;  Kong, Qinghua;  Kong, Qingpeng;  Li, Fei;  Xiong, Wenyong
View  |  Adobe PDF(9525Kb)  |  Favorite  |  View/Download:22/5  |  Submit date:2024/04/30
RACK1  bile acid  glucose metabolism  insulin sensitivity  ENDOPLASMIC-RETICULUM STRESS  C-KINASE 1  HEPATOCELLULAR-CARCINOMA  STEROL 12-ALPHA-HYDROXYLASE  DOWN-REGULATION  ER STRESS  KAPPA-B  RECEPTOR  ACTIVATION  GROWTH  
四种高含量天然产物的化学及生物功能研究 学位论文
, 2021
Authors:  周元飞
Adobe PDF(13409Kb)  |  Favorite  |  View/Download:20/0  |  Submit date:2024/03/20