Sesquiterpenes from Carpesium faberi triggered ROS-induced apoptosis and protective autophagy in hepatocellular carcinoma cells

doi:10.1016/j.phytochem.2023.113805

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	Sesquiterpenes from Carpesium faberi triggered ROS-induced apoptosis and protective autophagy in hepatocellular carcinoma cells
	Yan,Ying; Chen,Jie; Peng,Mingyou; Zhang,Xiong; Feng,Enming; Li,Qindan; Guo,Bing; Ding,Xiao; Zhang,Yu; Tang,Lei
	2023
发表期刊	PHYTOCHEMISTRY
ISSN	1873-3700
卷号	214 页码:113805
摘要	Ten previously undescribed sesquiterpenes, carpespenes A-J (1-10), and eight known compounds (11-18), were isolated from the whole plants of Carpesium faberi. Their structures were established by extensive analysis of HRESIMS, NMR, and ECD spectra. Carpespene A (1) is eudesmanolide-type sesquiterpene lactone with an open five membered ring involving C-2 and C-3. Furthermore, compound 1 showed significant cytotoxic effects against four cancer cell lines with IC50 values from 8.20 to 18.45 & mu;M, compared with the positive controls cisplatin and doxorubicin. Mechanistically, compound 1 induced apoptosis in the HepG2 cells by triggering excessive ROS accumulation. The latter however induced cytoprotective autophagy, which impaired the cytotoxicity of compound 1. Simultaneous antophagy inhibition with compound 1 treatment augmented the cytotoxic effects of the latter on HepG2 cells. Our findings further establish the structural diversity and bioactivity of sesquiterpenes, and provide an experimental basis for targeting cytoprotective autophagy as a potential chemotherapeutic strategy.
关键词	Carpesium faberi (compositae) Sesquiterpenes Structural elucidation Cytotoxic activities Autophagy LACTONE DIMERS MYRRHANONE C XANTHANOLIDES TRITERPENE HYBRIDS ESTERS
DOI	10.1016/j.phytochem.2023.113805
收录类别	SCI
WOS记录号	WOS:001059519000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75526
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yan,Ying,Chen,Jie,Peng,Mingyou,et al. Sesquiterpenes from Carpesium faberi triggered ROS-induced apoptosis and protective autophagy in hepatocellular carcinoma cells[J]. PHYTOCHEMISTRY,2023,214:113805.
APA	Yan,Ying.,Chen,Jie.,Peng,Mingyou.,Zhang,Xiong.,Feng,Enming.,...&Tang,Lei.(2023).Sesquiterpenes from Carpesium faberi triggered ROS-induced apoptosis and protective autophagy in hepatocellular carcinoma cells.PHYTOCHEMISTRY,214,113805.
MLA	Yan,Ying,et al."Sesquiterpenes from Carpesium faberi triggered ROS-induced apoptosis and protective autophagy in hepatocellular carcinoma cells".PHYTOCHEMISTRY 214(2023):113805.

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