Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology

doi:10.3390/ijms24021088

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	Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology
	Yan,Ying; Zhou,Qi; Ran,Xiaoqian; Lu,Qingyun; Zhang,Cuishan; Peng,Mingyou; Tang,Lei; Luo,Rongcan; Di,Yingtong; Hao,Xiaojiang
	2023
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN	1422-0067
卷号	24 期号:2 页码:1088
摘要	Ten jatrophane diterpenoids were isolated from the whole plant Euphorbia peplus Linn. including seven new ones, named euphjatrophanes A-G (labeled compounds 1, 2, 4-8). Their structures were elucidated with a combination of spectroscopic and single-crystal X-ray crystallography, enabling the identification of compounds 3, 9, and 10 as the previously published euphpepluones G, K, and L, respectively. All compounds were evaluated for their bioactivity with flow cytometry in assays of autophagic flux in HM Cherry-GFP-LC3 (human microglia cells stably expressing the tandem monomeric mCherry-GFP-tagged LC3) cells. Euphpepluone K (9) significantly activated autophagic flux, an effect that was verified with confocal analysis. Moreover, cellular assays showed that euphpepluone K (9) induced autophagy and inhibited Tau pathology.
关键词	euphjatrophane Euphorbia peplus jatrophane diterpenoid autophagy Tau pathology UBIQUITIN-PROTEASOME SYSTEM MULTIDRUG-RESISTANCE BIOLOGICAL-ACTIVITY ALZHEIMERS-DISEASE MODULATORS CELLS
学科领域	Biochemistry & Molecular Biology ; Chemistry
DOI	10.3390/ijms24021088
WOS记录号	WOS:000917637200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75011
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yan,Ying,Zhou,Qi,Ran,Xiaoqian,et al. Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(2):1088.
APA	Yan,Ying.,Zhou,Qi.,Ran,Xiaoqian.,Lu,Qingyun.,Zhang,Cuishan.,...&Hao,Xiaojiang.(2023).Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(2),1088.
MLA	Yan,Ying,et al."Jatrophane Diterpenoids from Euphorbia peplus Linn. as Activators of Autophagy and Inhibitors of Tau Pathology".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.2(2023):1088.

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