New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217)

doi:10.3390/ijms24021487

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	New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217)
	Li,Sheng; Han,Ling-Ling; Huang,Ke-Pu; Ma,Ye-Han; Guo,Ling-Li; Guo,Yarong; Ran,Xiaoqian; Yao,Yong-Gang; Hao,Xiao-Jiang; Luo,Rongcan; Zhang,Yu
	2023
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN	1422-0067
卷号	24 期号:2 页码:1487
摘要	Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A-C (1-3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan-ibogan-type bisindole alkaloid which is formed by the polymerization of two classic ibogan-type monomers through a C3 unit aliphatic chain. Their structures were established by extensive analysis of HRESIMS, NMR, and ECD spectra. Cellular assays showed that alkaloids 1-3 all reduce A beta 42 production and inhibit phospho-tau (Thr217), a new biomarker of Alzheimer's disease [AD] associated with BACE1-, NCSTN-, GSK3 beta-, and CDK5-mediated pathways, suggesting these alkaloids' potential against AD.
关键词	Tabernaemontana crassa monoterpenoid indole alkaloids A beta 42 phospho-tau (Thr217) Alzheimer's disease ALZHEIMERS-DISEASE BISINDOLE ALKALOIDS CDK5 GEMFIBROZIL PREVENTION ALGORITHM AUTOPHAGY MODELS PLANTS MOUSE
学科领域	Biochemistry & Molecular Biology ; Chemistry
DOI	10.3390/ijms24021487
WOS记录号	WOS:000919613400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75013
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Li,Sheng,Han,Ling-Ling,Huang,Ke-Pu,et al. New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217)[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(2):1487.
APA	Li,Sheng.,Han,Ling-Ling.,Huang,Ke-Pu.,Ma,Ye-Han.,Guo,Ling-Li.,...&Zhang,Yu.(2023).New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217).INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(2),1487.
MLA	Li,Sheng,et al."New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit beta-Amyloid42 Production and Phospho-Tau (Thr217)".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.2(2023):1487.

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