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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii
期刊论文
PHYTOMEDICINE, 2023, 卷号: 121, 页码: 155054
Authors:
Dai,Manyun
;
Peng,Wan
;
Lin,Lisha
;
Wu,Zhanxuan
;
Zhang,Ting
;
Zhao,Qi
;
Cheng,Yan
;
Lin,Qiuxia
;
Zhang,Binbin
;
Liu,Aiming
;
Rao,Qianru
;
Huang,Jianfeng
;
Zhao,Jinhua
;
Gonzalez,Frank J.
;
Li,Fei
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Submit date:2024/07/17
Intestinal bleeding
Triptolide
Celastrol
Intestinal FXR
Tripterygium wilfordii
FARNESOID-X-RECEPTOR
BACTERIAL TRANSLOCATION
ACTIVATION
INFLAMMATION
DYSFUNCTION
TRIPTOLIDE
MICROBIOTA
PREVENTS
OBESITY
MICE
Tripterygium wilfordii protects against an animal model of autoimmune hepatitis
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 309, 页码: 116365
Authors:
Zhang,Ting
;
Rao,Qianru
;
Dai,Manyun
;
Zhao,Qi
;
Li,Fei
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Submit date:2024/07/25
Tripterygium wilfordii tablets
Celastrol
Concanavalin A
Autophagy
TFEB
PXR
PREGNANE-X-RECEPTOR
CHOLESTATIC LIVER-INJURY
CELASTROL PROTECTS
AUTOPHAGY
OBESITY
DYSFUNCTION
DOMAIN
Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice
期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 1829
Authors:
Zhao,Qi
;
Dai,Man-Yun
;
Huang,Ruo-Yue
;
Duan,Jing-Yi
;
Zhang,Ting
;
Bao,Wei-Min
;
Zhang,Jing-Yi
;
Gui,Shao-Qiang
;
Xia,Shu-Min
;
Dai,Cong-Ting
;
Tang,Ying-Mei
;
Gonzalez,Frank J. J.
;
Li,Fei
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Submit date:2024/05/09
FATTY LIVER-DISEASE
INDUCED CHOLESTASIS
STELLATE CELLS
PROBIOTICS
PROTECTS
INFLAMMATION
APOPTOSIS
OBESITY
AXIS
Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway
期刊论文
HELIYON, 2023, 卷号: 9, 期号: 2, 页码: e13691
Authors:
Ran,Xiaoqian
;
Lu,Qing-Yun
;
Li,Ying-Yao
;
Pu,Xue-Xue
;
Guo,Yarong
;
Yuan,Ming-Rui
;
Guan,Shi-Peng
;
Sun,Mao
;
Jiao,Lijin
;
Yao,Yong-Gang
;
Di,Ying-Tong
;
Hao,Xiao-Jiang
;
Luo,Rongcan
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Submit date:2024/07/30
Euphorbia peplus L
Euphorbiaceae
Ent-abietane diterpenoid
Euphejolkinolide A
Autophagy-lysosomal pathway
ALZHEIMERS-DISEASE
TAU PATHOLOGY
NEURODEGENERATION
DITERPENOIDS
INHIBITION
MECHANISMS
APOPTOSIS
CELASTROL
PROTEIN
SYSTEM
Metabolomics reveals the role of PPAR alpha in Tripterygium Wilfordii-induced liver injury
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2022, 卷号: 289, 页码: 16
Authors:
Dai, Manyun
;
Peng, Wan
;
Zhang, Ting
;
Zhao, Qi
;
Ma, Xiaofang
;
Cheng, Yan
;
Wang, Chunyan
;
Li, Fei
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Submit date:2022/07/15
Tripterygium wilfordii
Liver injury
PPAR alpha
IL6-STAT3
Metabolomics
雷公藤红素衍生物的保肝和降脂活性研究
学位论文
, 2021
Authors:
包丽娟
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Submit date:2024/03/20
Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans
期刊论文
ORGANIC LETTERS, 2021, 卷号: 23, 期号: 19, 页码: 7462-7466
Authors:
Hua,Juan
;
Liu,Yan-Chun
;
Luo,Shi-Hong
;
Liu,Yan
;
Xiao,Chao-Jiang
;
Li,Xiao-Nian
;
Li,Sheng-Hong
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Submit date:2022/04/02
QUILLAJA-SAPONARIA
BIOSYNTHESIS
MECHANISMS
ADJUVANTS
VARIANTS
PRODUCTS
CYCLASE
The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and alpha-glucosidase dual inhibitors
期刊论文
INDUSTRIAL CROPS AND PRODUCTS, 2021, 卷号: 160, 页码: 112908
Authors:
He,Xiao-Feng
;
Chen,Ji-Jun
;
Huang,Xiao-Yan
;
Hu,Jing
;
Zhang,Xu-Ke
;
Guo,Yuan-Qiang
;
Zhang,Xue-Mei
;
Geng,Chang-An
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Submit date:2022/04/02
Amomum tsao-ko
Amomutsaokins A-H
Flavanol-menthane conjugates
PTP1B selective inhibitors
alpha-Glucosidase inhibitors
ANTIOXIDANT ACTIVITY
ESSENTIAL OIL
CONSTITUENTS
TANNINS
CREVOST
ACID
Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963
Authors:
Liu,Jiangxin
;
Wu,Xing-De
;
Li,Wenyan
;
Yuan,Zaifeng
;
Yang,Kun
;
Zhao,Qin-Shi
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Submit date:2022/04/02
Pseudolaric acid A
Hsp90 inhibitor
Apoptosis
NMR
Structure-activity relationship
Photoaffinity-based probe
Protein-ligand interaction
MOLECULAR CHAPERONE
PROTEIN
TARGET
CANCER
KINASE
NMR
IDENTIFICATION
SELECTIVITY
BINDING
DESIGN
康定鼠尾草中抗血小板活性松香烷二萜的研究
学位论文
, 2020
Authors:
夏凡
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Submit date:2023/11/02