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Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii 期刊论文
PHYTOMEDICINE, 2023, 卷号: 121, 页码: 155054
Authors:  Dai,Manyun;  Peng,Wan;  Lin,Lisha;  Wu,Zhanxuan;  Zhang,Ting;  Zhao,Qi;  Cheng,Yan;  Lin,Qiuxia;  Zhang,Binbin;  Liu,Aiming;  Rao,Qianru;  Huang,Jianfeng;  Zhao,Jinhua;  Gonzalez,Frank J.;  Li,Fei
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Intestinal bleeding  Triptolide  Celastrol  Intestinal FXR  Tripterygium wilfordii  FARNESOID-X-RECEPTOR  BACTERIAL TRANSLOCATION  ACTIVATION  INFLAMMATION  DYSFUNCTION  TRIPTOLIDE  MICROBIOTA  PREVENTS  OBESITY  MICE  
Tripterygium wilfordii protects against an animal model of autoimmune hepatitis 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 309, 页码: 116365
Authors:  Zhang,Ting;  Rao,Qianru;  Dai,Manyun;  Zhao,Qi;  Li,Fei
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Tripterygium wilfordii tablets  Celastrol  Concanavalin A  Autophagy  TFEB  PXR  PREGNANE-X-RECEPTOR  CHOLESTATIC LIVER-INJURY  CELASTROL PROTECTS  AUTOPHAGY  OBESITY  DYSFUNCTION  DOMAIN  
Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice 期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 1829
Authors:  Zhao,Qi;  Dai,Man-Yun;  Huang,Ruo-Yue;  Duan,Jing-Yi;  Zhang,Ting;  Bao,Wei-Min;  Zhang,Jing-Yi;  Gui,Shao-Qiang;  Xia,Shu-Min;  Dai,Cong-Ting;  Tang,Ying-Mei;  Gonzalez,Frank J. J.;  Li,Fei
View  |  Adobe PDF(5393Kb)  |  Favorite  |  View/Download:113/16  |  Submit date:2024/05/09
FATTY LIVER-DISEASE  INDUCED CHOLESTASIS  STELLATE CELLS  PROBIOTICS  PROTECTS  INFLAMMATION  APOPTOSIS  OBESITY  AXIS  
Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway 期刊论文
HELIYON, 2023, 卷号: 9, 期号: 2, 页码: e13691
Authors:  Ran,Xiaoqian;  Lu,Qing-Yun;  Li,Ying-Yao;  Pu,Xue-Xue;  Guo,Yarong;  Yuan,Ming-Rui;  Guan,Shi-Peng;  Sun,Mao;  Jiao,Lijin;  Yao,Yong-Gang;  Di,Ying-Tong;  Hao,Xiao-Jiang;  Luo,Rongcan
View  |  Adobe PDF(10283Kb)  |  Favorite  |  View/Download:64/23  |  Submit date:2024/07/30
Euphorbia peplus L  Euphorbiaceae  Ent-abietane diterpenoid  Euphejolkinolide A  Autophagy-lysosomal pathway  ALZHEIMERS-DISEASE  TAU PATHOLOGY  NEURODEGENERATION  DITERPENOIDS  INHIBITION  MECHANISMS  APOPTOSIS  CELASTROL  PROTEIN  SYSTEM  
Metabolomics reveals the role of PPAR alpha in Tripterygium Wilfordii-induced liver injury 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2022, 卷号: 289, 页码: 16
Authors:  Dai, Manyun;  Peng, Wan;  Zhang, Ting;  Zhao, Qi;  Ma, Xiaofang;  Cheng, Yan;  Wang, Chunyan;  Li, Fei
Favorite  |  View/Download:396/0  |  Submit date:2022/07/15
Tripterygium wilfordii  Liver injury  PPAR alpha  IL6-STAT3  Metabolomics  
雷公藤红素衍生物的保肝和降脂活性研究 学位论文
, 2021
Authors:  包丽娟
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Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans 期刊论文
ORGANIC LETTERS, 2021, 卷号: 23, 期号: 19, 页码: 7462-7466
Authors:  Hua,Juan;  Liu,Yan-Chun;  Luo,Shi-Hong;  Liu,Yan;  Xiao,Chao-Jiang;  Li,Xiao-Nian;  Li,Sheng-Hong
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QUILLAJA-SAPONARIA  BIOSYNTHESIS  MECHANISMS  ADJUVANTS  VARIANTS  PRODUCTS  CYCLASE  
The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and alpha-glucosidase dual inhibitors 期刊论文
INDUSTRIAL CROPS AND PRODUCTS, 2021, 卷号: 160, 页码: 112908
Authors:  He,Xiao-Feng;  Chen,Ji-Jun;  Huang,Xiao-Yan;  Hu,Jing;  Zhang,Xu-Ke;  Guo,Yuan-Qiang;  Zhang,Xue-Mei;  Geng,Chang-An
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Amomum tsao-ko  Amomutsaokins A-H  Flavanol-menthane conjugates  PTP1B selective inhibitors  alpha-Glucosidase inhibitors  ANTIOXIDANT ACTIVITY  ESSENTIAL OIL  CONSTITUENTS  TANNINS  CREVOST  ACID  
Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963
Authors:  Liu,Jiangxin;  Wu,Xing-De;  Li,Wenyan;  Yuan,Zaifeng;  Yang,Kun;  Zhao,Qin-Shi
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Pseudolaric acid A  Hsp90 inhibitor  Apoptosis  NMR  Structure-activity relationship  Photoaffinity-based probe  Protein-ligand interaction  MOLECULAR CHAPERONE  PROTEIN  TARGET  CANCER  KINASE  NMR  IDENTIFICATION  SELECTIVITY  BINDING  DESIGN  
康定鼠尾草中抗血小板活性松香烷二萜的研究 学位论文
, 2020
Authors:  夏凡
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