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Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii 期刊论文
PHYTOMEDICINE, 2023, 卷号: 121, 页码: 155054
Authors:  Dai,Manyun;  Peng,Wan;  Lin,Lisha;  Wu,Zhanxuan;  Zhang,Ting;  Zhao,Qi;  Cheng,Yan;  Lin,Qiuxia;  Zhang,Binbin;  Liu,Aiming;  Rao,Qianru;  Huang,Jianfeng;  Zhao,Jinhua;  Gonzalez,Frank J.;  Li,Fei
View  |  Adobe PDF(17974Kb)  |  Favorite  |  View/Download：103/19  |  Submit date：2024/07/17
Intestinal bleeding  Triptolide  Celastrol  Intestinal FXR  Tripterygium wilfordii  FARNESOID-X-RECEPTOR  BACTERIAL TRANSLOCATION  ACTIVATION  INFLAMMATION  DYSFUNCTION  TRIPTOLIDE  MICROBIOTA  PREVENTS  OBESITY  MICE  
Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice 期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 1829
Authors:  Zhao,Qi;  Dai,Man-Yun;  Huang,Ruo-Yue;  Duan,Jing-Yi;  Zhang,Ting;  Bao,Wei-Min;  Zhang,Jing-Yi;  Gui,Shao-Qiang;  Xia,Shu-Min;  Dai,Cong-Ting;  Tang,Ying-Mei;  Gonzalez,Frank J. J.;  Li,Fei
View  |  Adobe PDF(5393Kb)  |  Favorite  |  View/Download：114/16  |  Submit date：2024/05/09
FATTY LIVER-DISEASE  INDUCED CHOLESTASIS  STELLATE CELLS  PROBIOTICS  PROTECTS  INFLAMMATION  APOPTOSIS  OBESITY  AXIS  
Diverse aging rates in ectothermic tetrapods provide insights for the evolution of aging and longevity 期刊论文
SCIENCE, 2022, 卷号: 376, 期号: 6600, 页码: 1459-+
Authors:  Reinke, Beth A.;  Cayuela, Hugo;  Janzen, Fredric J.;  Lemaitre, Jean-Francois;  Gaillard, Jean-Michel;  Lawing, A. Michelle;  Iverson, John B.;  Christiansen, Ditte G.;  Martinez-Solano, Inigo;  Sanchez-Montes, Gregorio;  Gutierrez-Rodriguez, Jorge;  Rose, Francis L.;  Nelson, Nicola;  Keall, Susan;  Crivelli, Alain J.;  Nazirides, Theodoros;  Grimm-Seyfarth, Annegret;  Henle, Klaus;  Mori, Emiliano;  Guiller, Gaetan;  Homan, Rebecca;  Olivier, Anthony;  Muths, Erin;  Hossack, Blake R.;  Bonnet, Xavier;  Pilliod, David S.;  Lettink, Marieke;  Whitaker, Tony;  Schmidt, Benedikt R.;  Gardner, Michael G.;  Cheylan, Marc;  Poitevin, Francoise;  Golubovic, Ana;  Tomovic, Ljiljana;  Arsovski, Dragan;  Griffiths, Richard A.;  Arntzen, Jan W.;  Baron, Jean-Pierre;  Le Galliard, Jean-Francois;  Tully, Thomas;  Luiselli, Luca;  Capula, Massimo;  Rugiero, Lorenzo;  McCaffery, Rebecca;  Eby, Lisa A.;  Briggs-Gonzalez, Venetia;  Mazzotti, Frank;  Pearson, David;  Lambert, Brad A.;  Green, David M.;  Jreidini, Nathalie;  Angelini, Claudio;  Pyke, Graham;  Thirion, Jean-Marc;  Joly, Pierre;  Lena, Jean-Paul;  Tucker, Anton D.;  Limpus, Col;  Priol, Pauline;  Besnard, Aurelien;  Bernard, Pauline;  Stanford, Kristin;  King, Richard;  Garwood, Justin;  Bosch, Jaime;  Souza, Franco L.;  Bertoluci, Jaime;  Famelli, Shirley;  Grossenbacher, Kurt;  Lenzi, Omar;  Matthews, Kathleen;  Boitaud, Sylvain;  Olson, Deanna H.;  Jessop, Tim S.;  Gillespie, Graeme R.;  Clobert, Jean;  Richard, Murielle;  Valenzuela-Sanchez, Andres;  Fellers, Gary M.;  Kleeman, Patrick M.;  Halstead, Brian J.;  Grant, Evan H. Campbell;  Byrne, Phillip G.;  Fretey, Thierry;  Le Garff, Bernard;  Levionnois, Pauline;  Maerz, John C.;  Pichenot, Julian;  Olgun, Kurtulus;  Uzum, Nazan;  Avci, Aziz;  Miaud, Claude;  Elmberg, Johan;  Brown, Gregory P.;  Shine, Richard;  Bendik, Nathan F.;  O'Donnell, Lisa;  Davis, Courtney L.;  Lannoo, Michael J.;  Stiles, Rochelle M.;  Cox, Robert M.;  Reedy, Aaron M.;  Warner, Daniel A.;  Bonnaire, Eric;  Grayson, Kristine;  Ramos-Targarona, Roberto;  Baskale, Eyup;  Munoz, David;  Measey, John;  de Villiers, F. Andre;  Selman, Will;  Ronget, Victor;  Bronikowski, Anne M.;  Miller, David A. W.
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Polyamine metabolism links gut microbiota and testicular dysfunction 期刊论文
MICROBIOME, 2021, 卷号: 9, 期号: 1, 页码: 224
Authors:  Zhao,Qi;  Huang,Jian-Feng;  Cheng,Yan;  Dai,Man-Yun;  Zhu,Wei-Feng;  Yang,Xiu-Wei;  Gonzalez,Frank J.;  Li,Fei
Favorite  |  View/Download：106/0  |  Submit date：2022/04/02
Testicular dysfunction  Gut microbiota  Polyamine metabolism  Metabolomics  SMALL-MOLECULE INHIBITOR  ORNITHINE-DECARBOXYLASE  TRIPTOLIDE  SPERMINE  ACTIVATION  DISRUPTION  MECHANISMS  EXPRESSION  APOPTOSIS  TRANSPORT  
Celastrol ameliorates acute liver injury through modulation of PPAR alpha 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020
Authors:  Zhao, Qi;  Tang, Ping;  Zhang, Ting;  Huang, Jian-Feng;  Xiao, Xue-Rong;  Zhu, Wei-Feng;  Gonzalez, Frank J.;  Li, Fei
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Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1 期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2019, 卷号: 32, 期号: 10, 页码: 1965-1976
Authors:  Yang, Xiao-Nan;  Wang, Yi-Kun;  Zhu, Xu;  Xiao, Xue-Rong;  Dai, Man-Yun;  Zhang, Ting;  Qu, Yan;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Gonzalez, Frank J.;  Li, Fei
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The Protective Roles of PPAR alpha Activation in Triptolide-Induced Liver Injury 期刊论文
TOXICOLOGICAL SCIENCES, 2019, 卷号: 171, 期号: 1, 页码: 1-12
Authors:  Hu, Dan-Dan;  Zhao, Qi;  Cheng, Yan;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Qu, Yan;  Li, Xian;  Tang, Ying-Mei;  Bao, Wei-Min;  Yang, Jin-Hui;  Jiang, Tao;  Hu, Jia-Peng;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(1740Kb)  |  Favorite  |  View/Download：320/60  |  Submit date：2020/03/26
liver injury  metabolomics  PPAR alpha  acylcarnitines  
Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 29, 页码: 8243-8252
Authors:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Zhu, Xu;  Xiao, Xue-Rong;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(3136Kb)  |  Favorite  |  View/Download：244/72  |  Submit date：2019/09/10
elemicin  l'-hydroxyelemicin  metabolic activation  cytotoxicity  
Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2162-2178
Authors:  Zhao, Qi;  Zhang, Ting;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Wang, Yan;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(3915Kb)  |  Favorite  |  View/Download：357/47  |  Submit date：2019/07/29
A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice 期刊论文
XENOBIOTICA, 2019, 卷号: 49, 期号: 6, 页码: 655-670
Authors:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Liang, Wei-Qing;  Xiao, Yao;  Zhao, Qi;  Xiao, Xue-Rong;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(1101Kb)  |  Favorite  |  View/Download：329/121  |  Submit date：2019/07/29
Pazopanib  hepatotoxicity  metabolomics  oxidative stress  ultra-performance liquid chromatography-electrospray ion source-quadrupole  time-of-flight mass spectrometer (UPLC-ESI-QTOFMS)