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Metabolic profiling of tyrosine kinase inhibitor nintedanib using metabolomics 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 卷号: 180, 页码: 13
Authors:  Zhou, Zi-Meng;  Wang, Yi-Kun;  Yan, Dong-Mei;  Fang, Jian-He;  Xiao, Xue-Rong;  Zhang, Ting;  Cheng, Yan;  Xu, Kang-Ping;  Li, Fei
Favorite  |  View/Download:4/0  |  Submit date:2020/05/27
Nintedanib  Metabolism  Metabolomics  ADMET prediction  UPLC-ESI-QTOF-MS  
A Novel bis-indole Alkaloid from the Flowers of Rauvolfia yunnanensis Tsiang and its Antihypertension Activity 期刊论文
LETTERS IN ORGANIC CHEMISTRY, 2020, 卷号: 17, 期号: 2, 页码: 96-100
Authors:  Wang, Haibo;  Liu, Xikui
Favorite  |  View/Download:7/0  |  Submit date:2020/03/18
Alkaloid  Bis-indole alkaloid  Rauvolfia yunnanensis  rauvolfia flowers  antihypertension  reserpine  
Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 13
Authors:  Zhou, Yeheng;  Sun, Wei;  Peng, Jiale;  Yan, Hui;  Zhang, Li;  Liu, Xingyong;  Zuo, Zhili
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Acetylcholinesterase  Drug design  N-acylhydrazone  Dementia  Copper-chelating  N-Benzylpiperidine  
Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1 期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2019, 卷号: 32, 期号: 10, 页码: 1965-1976
Authors:  Yang, Xiao-Nan;  Wang, Yi-Kun;  Zhu, Xu;  Xiao, Xue-Rong;  Dai, Man-Yun;  Zhang, Ting;  Qu, Yan;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Gonzalez, Frank J.;  Li, Fei
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Resource diversity of Chinese macrofungi: edible, medicinal and poisonous species 期刊论文
FUNGAL DIVERSITY, 2019, 卷号: 98, 期号: 1, 页码: 1-76
Authors:  Wu, Fang;  Zhou, Li-Wei;  Yang, Zhu-Liang;  Bau, Tolgor;  Li, Tai-Hui;  Dai, Yu-Cheng
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Economic fungi  Edible mushroom  Fungal toxicity  Medicinal function  Nomenclature  
The Protective Roles of PPAR alpha Activation in Triptolide-Induced Liver Injury 期刊论文
TOXICOLOGICAL SCIENCES, 2019, 卷号: 171, 期号: 1, 页码: 1-12
Authors:  Hu, Dan-Dan;  Zhao, Qi;  Cheng, Yan;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Qu, Yan;  Li, Xian;  Tang, Ying-Mei;  Bao, Wei-Min;  Yang, Jin-Hui;  Jiang, Tao;  Hu, Jia-Peng;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(1740Kb)  |  Favorite  |  View/Download:8/0  |  Submit date:2020/03/26
liver injury  metabolomics  PPAR alpha  acylcarnitines  
Acute and subacute toxicity evaluation of ethanol extract from aerial parts of Epigynum auritum in mice 期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2019, 卷号: 131, 页码: 8
Authors:  Yang, Meilian;  Wu, Zihuan;  Wang, Yudan;  Kai, Guoyin;  Njateng, Guy Sedar Singor;  Cai, Shengbao;  Cao, Jianxin;  Cheng, Guiguang
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Epigynum auritum  Acute and subacute oral toxicities  Hematology  Histopathology  Serum biochemistry analysis  
Role of Metabolic Activation in Elemicin-Induced Cellular Toxicity 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 29, 页码: 8243-8252
Authors:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Zhu, Xu;  Xiao, Xue-Rong;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(3136Kb)  |  Favorite  |  View/Download:19/4  |  Submit date:2019/09/10
elemicin  l'-hydroxyelemicin  metabolic activation  cytotoxicity  
Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2162-2178
Authors:  Zhao, Qi;  Zhang, Ting;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Wang, Yan;  Gonzalez, Frank J.;  Li, Fei
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A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice 期刊论文
XENOBIOTICA, 2019, 卷号: 49, 期号: 6, 页码: 655-670
Authors:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Liang, Wei-Qing;  Xiao, Yao;  Zhao, Qi;  Xiao, Xue-Rong;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(1101Kb)  |  Favorite  |  View/Download:42/4  |  Submit date:2019/07/29
Pazopanib  hepatotoxicity  metabolomics  oxidative stress  ultra-performance liquid chromatography-electrospray ion source-quadrupole  time-of-flight mass spectrometer (UPLC-ESI-QTOFMS)