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Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii 期刊论文
PHYTOMEDICINE, 2023, 卷号: 121, 页码: 155054
Authors:  Dai,Manyun;  Peng,Wan;  Lin,Lisha;  Wu,Zhanxuan;  Zhang,Ting;  Zhao,Qi;  Cheng,Yan;  Lin,Qiuxia;  Zhang,Binbin;  Liu,Aiming;  Rao,Qianru;  Huang,Jianfeng;  Zhao,Jinhua;  Gonzalez,Frank J.;  Li,Fei
View  |  Adobe PDF(17974Kb)  |  Favorite  |  View/Download：103/19  |  Submit date：2024/07/17
Intestinal bleeding  Triptolide  Celastrol  Intestinal FXR  Tripterygium wilfordii  FARNESOID-X-RECEPTOR  BACTERIAL TRANSLOCATION  ACTIVATION  INFLAMMATION  DYSFUNCTION  TRIPTOLIDE  MICROBIOTA  PREVENTS  OBESITY  MICE  
Tripterygium wilfordii protects against an animal model of autoimmune hepatitis 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 309, 页码: 116365
Authors:  Zhang,Ting;  Rao,Qianru;  Dai,Manyun;  Zhao,Qi;  Li,Fei
View  |  Adobe PDF(13950Kb)  |  Favorite  |  View/Download：53/16  |  Submit date：2024/07/25
Tripterygium wilfordii tablets  Celastrol  Concanavalin A  Autophagy  TFEB  PXR  PREGNANE-X-RECEPTOR  CHOLESTATIC LIVER-INJURY  CELASTROL PROTECTS  AUTOPHAGY  OBESITY  DYSFUNCTION  DOMAIN  
Metabolomics reveals the role of PPAR alpha in Tripterygium Wilfordii-induced liver injury 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2022, 卷号: 289, 页码: 16
Authors:  Dai, Manyun;  Peng, Wan;  Zhang, Ting;  Zhao, Qi;  Ma, Xiaofang;  Cheng, Yan;  Wang, Chunyan;  Li, Fei
Favorite  |  View/Download：397/0  |  Submit date：2022/07/15
Tripterygium wilfordii  Liver injury  PPAR alpha  IL6-STAT3  Metabolomics  
雷公藤制剂对消化系统的毒性机理研究 学位论文
: 中国科学院大学, 2022
Authors:  代曼云
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代谢组学，雷公藤，药源性肝损伤，消化性溃疡，FXR，ET-1， 肠道血管屏障  Metabolomics, Tripterygium wilfordii, Drug-induced liver injury, peptic ulcer disease, FXR, ET-1, intestinal vascular barrier.  
雷公藤制剂肝毒性的机制及其调节作用研究 学位论文
, 2021
Authors:  彭婉
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FXR activation prevents liver injury induced by Tripterygium wilfordii preparations 期刊论文
XENOBIOTICA, 2021, 卷号: 51, 期号: 6, 页码: 716-727
Authors:  Peng,Wan;  Dai,Man-Yun;  Bao,Li-Juan;  Zhu,Wei-Feng;  Li,Fei
View  |  Adobe PDF(2010Kb)  |  Favorite  |  View/Download：182/20  |  Submit date：2022/04/02
Tripterygium wilfordii  liver injury  farnesoid X receptor  bile acid metabolism  metabolomics  
Cloning and Functional Characterization of a Squalene Synthase from Paris polyphylla var. yunnanensis 期刊论文
CHEMISTRY & BIODIVERSITY, 2021, 卷号: 18, 期号: 7
Authors:  Gao,Jian-Xiong;  Chen,Yue-Gui;  Li,De-Sen;  Lin,Liang;  Liu,Yan;  Li,Sheng-Hong
View  |  Adobe PDF(5087Kb)  |  Favorite  |  View/Download：208/45  |  Submit date：2022/04/02
Paris polyphylla var  Yunnanensis  squalene synthase  steroidal saponins  squalene  in vitro enzymatic assay  MOLECULAR-CLONING  SAPONINS  EXPRESSION  GENE  GLYCOSIDES  PLANTS  SQS  
An extremely promiscuous terpenoid synthase from the Lamiaceae plant Colquhounia coccinea var. mollis catalyzes the formation of sester-/di-/sesqui-/mono-terpenoids 期刊论文
PLANT COMMUNICATIONS, 2021, 卷号: 2, 期号: 5, 页码: 100233
Authors:  Li,De-Sen;  Hua,Juan;  Luo,Shi-Hong;  Liu,Yan-Chun;  Chen,Yue-Gui;  Ling,Yi;  Guo,Kai;  Liu,Yan;  Li,Sheng-Hong
View  |  Adobe PDF(2409Kb)  |  Favorite  |  View/Download：154/38  |  Submit date：2022/04/02
terpenoid diversity  terpenoid synthase  promiscuous enzyme  sester-/di-/sesqui-/mono-terpenoids  Colquhounia coccinea var  mollis  GERANYLFARNESYL DIPHOSPHATE SYNTHASE  GLANDULAR TRICHOMES  DITERPENE SYNTHASE  LEUCOSCEPTRUM-CANUM  IDENTIFICATION  BRASSICACEAE  BIOLOGY  FAMILY  HARBOR  GENES  
基于转录组数据的蔷薇类和天南星科系统发育基因组学研究 学位论文
, 2020
Authors:  赵磊
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基于代谢组学研究雷公藤甲素的睾丸毒性和肝毒性 学位论文
, 2020
Authors:  黄建锋
Adobe PDF(9093Kb)  |  Favorite  |  View/Download：38/0  |  Submit date：2023/11/02