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Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice 期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 1829
Authors:  Zhao,Qi;  Dai,Man-Yun;  Huang,Ruo-Yue;  Duan,Jing-Yi;  Zhang,Ting;  Bao,Wei-Min;  Zhang,Jing-Yi;  Gui,Shao-Qiang;  Xia,Shu-Min;  Dai,Cong-Ting;  Tang,Ying-Mei;  Gonzalez,Frank J. J.;  Li,Fei
View  |  Adobe PDF(5393Kb)  |  Favorite  |  View/Download:23/5  |  Submit date:2024/05/09
FATTY LIVER-DISEASE  INDUCED CHOLESTASIS  STELLATE CELLS  PROBIOTICS  PROTECTS  INFLAMMATION  APOPTOSIS  OBESITY  AXIS  
雷公藤制剂对消化系统的毒性机理研究 学位论文
: 中国科学院大学, 2022
Authors:  代曼云
Adobe PDF(10574Kb)  |  Favorite  |  View/Download:8/0  |  Submit date:2024/05/14
代谢组学,雷公藤,药源性肝损伤,消化性溃疡,FXR,ET-1, 肠道血管屏障  Metabolomics, Tripterygium wilfordii, Drug-induced liver injury, peptic ulcer disease, FXR, ET-1, intestinal vascular barrier.  
Polyamine metabolism links gut microbiota and testicular dysfunction 期刊论文
MICROBIOME, 2021, 卷号: 9, 期号: 1, 页码: 224
Authors:  Zhao,Qi;  Huang,Jian-Feng;  Cheng,Yan;  Dai,Man-Yun;  Zhu,Wei-Feng;  Yang,Xiu-Wei;  Gonzalez,Frank J.;  Li,Fei
Favorite  |  View/Download:51/0  |  Submit date:2022/04/02
Testicular dysfunction  Gut microbiota  Polyamine metabolism  Metabolomics  SMALL-MOLECULE INHIBITOR  ORNITHINE-DECARBOXYLASE  TRIPTOLIDE  SPERMINE  ACTIVATION  DISRUPTION  MECHANISMS  EXPRESSION  APOPTOSIS  TRANSPORT  
Discovery and validation of quality markers of Fructus Aurantii against acetylcholinesterase using metabolomics and bioactivity assays 期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 卷号: 44, 期号: 11, 页码: 2189-2205
Authors:  Wang,Yi-Kun;  Zhou,Zi-Meng;  Dai,Man-Yun;  Ma,Xiao-Fang;  Xiao,Xue-Rong;  Zhang,Shou-Wen;  Liu,Hong-Ning;  Li,Fei
View  |  Adobe PDF(2083Kb)  |  Favorite  |  View/Download:109/35  |  Submit date:2022/04/02
Fructus Aurantii  quality markers  metabolomics  serum pharmacochemistry  ultra high performance liquid chromatography  SERUM PHARMACOCHEMISTRY  RAT PLASMA  IDENTIFICATION  METABOLITES  IMMATURUS  COMPONENTS  EXTRACT  NEOHESPERIDIN  FINGERPRINT  NARINGIN  
FXR activation prevents liver injury induced by Tripterygium wilfordii preparations 期刊论文
XENOBIOTICA, 2021, 卷号: 51, 期号: 6, 页码: 716-727
Authors:  Peng,Wan;  Dai,Man-Yun;  Bao,Li-Juan;  Zhu,Wei-Feng;  Li,Fei
View  |  Adobe PDF(2010Kb)  |  Favorite  |  View/Download:112/15  |  Submit date:2022/04/02
Tripterygium wilfordii  liver injury  farnesoid X receptor  bile acid metabolism  metabolomics  
Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 203, 页码: 114200
Authors:  Zhou,Zi-Meng;  Yan,Dong-Mei;  Wang,Yi-Kun;  Zhang,Ting;  Xiao,Xue-Rong;  Dai,Man-Yun;  Zhang,Shou-Wen;  Liu,Hong-Ning;  Li,Fei
Favorite  |  View/Download:68/0  |  Submit date:2022/04/02
Raspberry  Q-markers  Quality evaluation  UPLC-ESI-QTOF-MS  COMPONENTS  ACTIVATION  PATHWAY  FRUITS  
Gut microbiota protects from triptolide-induced hepatotoxicity: Key role of propionate and its downstream signalling events 期刊论文
PHARMACOLOGICAL RESEARCH, 2020
Authors:  Huang, Jian-Feng;  Zhao, Qi;  Dai, Man-Yun;  Xiao, Xue-Rong;  Zhang, Ting;  Zhu, Wei-Feng;  Li, Fei
View  |  Adobe PDF(3869Kb)  |  Favorite  |  View/Download:149/37  |  Submit date:2021/01/05
Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1 期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2019, 卷号: 32, 期号: 10, 页码: 1965-1976
Authors:  Yang, Xiao-Nan;  Wang, Yi-Kun;  Zhu, Xu;  Xiao, Xue-Rong;  Dai, Man-Yun;  Zhang, Ting;  Qu, Yan;  Yang, Xiu-Wei;  Qin, Hong-Bo;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(9057Kb)  |  Favorite  |  View/Download:217/43  |  Submit date:2020/03/26
A phytochemical investigation of Stemona parviflora roots reveals several compounds with nematocidal activity 期刊论文
PHYTOCHEMISTRY, 2019, 卷号: 159, 页码: 208-215
Authors:  Huang, Sheng-Zhuo;  Kong, Fan-Dong;  Chen, Gao;  Cai, Xiang-Hai;  Zhou, Li-Man;  Ma, Qing-Yun;  Wang, Qi;  Mei, Wen-Li;  Dai, Hao-Fu;  Zhao, You-Xing
View  |  Adobe PDF(614Kb)  |  Favorite  |  View/Download:348/64  |  Submit date:2019/03/25
Stemona parviflora  Stemonaceae  Phenanthrene  Stilbene  Nematocidal activity