Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS

doi:10.1016/j.jpba.2021.114200

KIB OpenIR

	Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS
	Zhou,Zi-Meng ; Yan,Dong-Mei ; Wang,Yi-Kun ; Zhang,Ting ; Xiao,Xue-Rong ; Dai,Man-Yun ; Zhang,Shou-Wen ; Liu,Hong-Ning ; Li,Fei
	2021
发表期刊	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN	0731-7085
卷号	203 页码:114200
摘要	Raspberry, the fruit of Rubus Chingii Hu, has been used as a traditional Chinese medicine (TCM) to nourish kidney and strengthen Yang-qi. In order to determine the quality of raspberry, the quality markers (Q-markers) of raspberry that can improve renal function were investigated using UPLC-ESI-QTOF-MS in this study. The results of serum pharmacochemistry indicated that six components rutin, ellagic acid, kaempferol-3-rutinoside, astragalin, tiliroside, and goshonoside F5 in raspberry were absorbed into rat blood. The HEK293 cells treated with cisplatin were used to evaluate the kidney-protecting activity of these absorbed components. All these components could markedly inhibit cell damage induced by cisplatin and restore the levels of malondialdehyde (MDA) and catalase (CAT) in the cells, suggesting that these components may be the Q-markers of raspberry. More importantly, except for ellagic acid, other five Q-markers in raspberries from Dexing of Jiangxi province were higher than those from most of other areas. It is well known that Dexing raspberry is the Dao-di herbs raspberry used in the clinic of Chinese Medicine, demonstrating that these components could be used as Q-markers of raspberry. This study provides a reliable and valuable method for quality evaluation of raspberry. (c) 2021 Elsevier B.V. All rights reserved.
关键词	Raspberry Q-markers Quality evaluation UPLC-ESI-QTOF-MS COMPONENTS ACTIVATION PATHWAY FRUITS
DOI	10.1016/j.jpba.2021.114200
WOS记录号	WOS:000681070000002
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73053
专题	中国科学院昆明植物研究所
作者单位	1.Jiangxi Univ Chinese Med, Academician Workstn, Nanchang 330004, Jiangxi, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Jiangxi Univ Chinese Med, Res Ctr Nat Resources Chinese Med Mat & Ethn Med, Nanchang 33004, Jiangxi, Peoples R China 5.Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Lab Metabol & Drug Induced Liver Injury, Chengdu 610000, Peoples R China 6.China Natl Inst Standardizat, Subinst Food & Agr Standardizat, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Zhou,Zi-Meng,Yan,Dong-Mei,Wang,Yi-Kun,et al. Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2021,203:114200.
APA	Zhou,Zi-Meng.,Yan,Dong-Mei.,Wang,Yi-Kun.,Zhang,Ting.,Xiao,Xue-Rong.,...&Li,Fei.(2021).Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,203,114200.
MLA	Zhou,Zi-Meng,et al."Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 203(2021):114200.