Knowledge Management System of Kunming Institute of Botany,CAS
| Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS | |
| Zhou,Zi-Meng; Yan,Dong-Mei; Wang,Yi-Kun; Zhang,Ting; Xiao,Xue-Rong; Dai,Man-Yun; Zhang,Shou-Wen; Liu,Hong-Ning; Li,Fei | |
| 2021 | |
| Source Publication | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
 |
| ISSN | 0731-7085 |
| Volume | 203Pages:114200 |
| Abstract | Raspberry, the fruit of Rubus Chingii Hu, has been used as a traditional Chinese medicine (TCM) to nourish kidney and strengthen Yang-qi. In order to determine the quality of raspberry, the quality markers (Q-markers) of raspberry that can improve renal function were investigated using UPLC-ESI-QTOF-MS in this study. The results of serum pharmacochemistry indicated that six components rutin, ellagic acid, kaempferol-3-rutinoside, astragalin, tiliroside, and goshonoside F5 in raspberry were absorbed into rat blood. The HEK293 cells treated with cisplatin were used to evaluate the kidney-protecting activity of these absorbed components. All these components could markedly inhibit cell damage induced by cisplatin and restore the levels of malondialdehyde (MDA) and catalase (CAT) in the cells, suggesting that these components may be the Q-markers of raspberry. More importantly, except for ellagic acid, other five Q-markers in raspberries from Dexing of Jiangxi province were higher than those from most of other areas. It is well known that Dexing raspberry is the Dao-di herbs raspberry used in the clinic of Chinese Medicine, demonstrating that these components could be used as Q-markers of raspberry. This study provides a reliable and valuable method for quality evaluation of raspberry. (c) 2021 Elsevier B.V. All rights reserved. |
| Keyword | Raspberry Q-markers Quality evaluation UPLC-ESI-QTOF-MS COMPONENTS ACTIVATION PATHWAY FRUITS |
| DOI | 10.1016/j.jpba.2021.114200 |
| WOS ID | WOS:000681070000002 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/73053 |
| Collection | 中国科学院昆明植物研究所 |
| Affiliation | 1.Jiangxi Univ Chinese Med, Academician Workstn, Nanchang 330004, Jiangxi, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Jiangxi Univ Chinese Med, Res Ctr Nat Resources Chinese Med Mat & Ethn Med, Nanchang 33004, Jiangxi, Peoples R China 5.Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Lab Metabol & Drug Induced Liver Injury, Chengdu 610000, Peoples R China 6.China Natl Inst Standardizat, Subinst Food & Agr Standardizat, Beijing 100191, Peoples R China |
| Recommended Citation GB/T 7714 | Zhou,Zi-Meng,Yan,Dong-Mei,Wang,Yi-Kun,et al. Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2021,203:114200. |
| APA | Zhou,Zi-Meng.,Yan,Dong-Mei.,Wang,Yi-Kun.,Zhang,Ting.,Xiao,Xue-Rong.,...&Li,Fei.(2021).Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,203,114200. |
| MLA | Zhou,Zi-Meng,et al."Discovery of quality markers in Rubus Chingii Hu using UPLC-ESI-QTOF-MS".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 203(2021):114200. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment