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Discovery and validation of quality markers of Fructus Aurantii against acetylcholinesterase using metabolomics and bioactivity assays
Wang,Yi-Kun; Zhou,Zi-Meng; Dai,Man-Yun; Ma,Xiao-Fang; Xiao,Xue-Rong; Zhang,Shou-Wen; Liu,Hong-Ning; Li,Fei
2021
Source PublicationJOURNAL OF SEPARATION SCIENCE
ISSN1615-9306
Volume44Issue:11Pages:2189-2205
AbstractFructus Aurantii is a traditional medicated diet in East Asia. To determine the underlying chemical markers responsible for the quality and efficacy of Fructus Aurantii, a sensitive metabolomic method was applied to distinguish Fructus Aurantii in Jiangxi Province from other two geographical locations (Hunan Province and Chongqing City) in China. In the present study, multivariate analyses were adopted to compare chemical compositions in 21 batches of Fructus Aurantii samples. Among three geographical origins, 23 differential compounds were structurally identified. Serum pharmacochemistry exhibited that 22 components could be detected in rat serum. Six differential and absorbed components were selected as six potential markers. Statistical analysis revealed that the content of six markers varied widely in three origins of Fructus Aurantii. Six differential and absorbed components were evaluated further by biological activity. Neohesperidin, naringin, and meranzin showed inhibitory effect on acetylcholinesterase that regulates gastrointestinal motility in vitro and in silico, suggesting that these three components may be determined as the active biomarkers of Fructus Aurantii. These findings demonstrate the potential of biomarkers for identification and quality control of Fructus Aurantii.
KeywordFructus Aurantii quality markers metabolomics serum pharmacochemistry ultra high performance liquid chromatography SERUM PHARMACOCHEMISTRY RAT PLASMA IDENTIFICATION METABOLITES IMMATURUS COMPONENTS EXTRACT NEOHESPERIDIN FINGERPRINT NARINGIN
DOI10.1002/jssc.202001190
WOS IDWOS:000642261300001
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73532
Collection中国科学院昆明植物研究所
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Jiangxi Univ Tradit Chinese Med, Academician Workstn, Nanchang, Jiangxi, Peoples R China
4.Jiangxi Univ Tradit Chinese Med, Res Ctr Nat Resources Chinese Med Mat & Ethn Med, Nanchang 33004, Jiangxi, Peoples R China
5.Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Lab Metabol & Drug Induced Liver Injury, Chengdu, Peoples R China
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Wang,Yi-Kun,Zhou,Zi-Meng,Dai,Man-Yun,et al. Discovery and validation of quality markers of Fructus Aurantii against acetylcholinesterase using metabolomics and bioactivity assays[J]. JOURNAL OF SEPARATION SCIENCE,2021,44(11):2189-2205.
APA Wang,Yi-Kun.,Zhou,Zi-Meng.,Dai,Man-Yun.,Ma,Xiao-Fang.,Xiao,Xue-Rong.,...&Li,Fei.(2021).Discovery and validation of quality markers of Fructus Aurantii against acetylcholinesterase using metabolomics and bioactivity assays.JOURNAL OF SEPARATION SCIENCE,44(11),2189-2205.
MLA Wang,Yi-Kun,et al."Discovery and validation of quality markers of Fructus Aurantii against acetylcholinesterase using metabolomics and bioactivity assays".JOURNAL OF SEPARATION SCIENCE 44.11(2021):2189-2205.
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