Metabolomics reveals the role of PPAR alpha in Tripterygium Wilfordii-induced liver injury

doi:10.1016/j.jep.2022.115090

	Metabolomics reveals the role of PPAR alpha in Tripterygium Wilfordii-induced liver injury
	Dai, Manyun 1,2,3; Peng, Wan1,2,3,4 ; Zhang, Ting 1,2,3; Zhao, Qi3 ; Ma, Xiaofang 3; Cheng, Yan 3; Wang, Chunyan 3; Li, Fei 1,3,5
通讯作者	Li, Fei(feili@wchscu.cn)
	2022-05-10
发表期刊	JOURNAL OF ETHNOPHARMACOLOGY
ISSN	0378-8741
卷号	289 页码:16
摘要	Ethnopharmacological relevance: Tripterygium glycosides tablets (TGT) and Tripterygium wilfordii tablets (TWT) have been used to treat autoimmune diseases clinically, however, the side effects of TWT are higher than TGT, especially for hepatotoxicity. The aim of the study: This study aims to determine the mechanism of TWT-induced liver injury. Materials and methods: We performed metabolomic analysis of samples from mice with liver injury induced by TGT and TWT. Ppara-null mice were used to determine the role of PPAR alpha in TWT-induced liver injury. Results: The results indicated that TWT induced the accumulation of medium- and long-chain carnitines metabolism, which was associated with the disruption of PPAR alpha-IL6-STAT3 axis. PPAR alpha agonists fenofibrate could reverse the liver injury from TWT and TP/Cel, and its protective role could be attenuated in Ppara-null mice. The toxicity difference of TWT and TGT was due to the different ratio of triptolide (TP) and celastrol (Cel) in the tablet in which TP/Cel was lower in TWT than TGT. The hepatotoxicity induced by TP and Cel also inhibited PPAR alpha and upregulated IL6-STAT3 axis, which could be alleviated following by PPAR alpha activation. Conclusions: These results indicated that PPAR alpha plays an important role in the hepatotoxicity of Tripterygium wilfordii, and PPAR alpha activation may offer a promising approach to prevent hepatotoxicity induced by the preparations of Tripterygium wilfordii.
关键词	Tripterygium wilfordii Liver injury PPAR alpha IL6-STAT3 Metabolomics
DOI	10.1016/j.jep.2022.115090
收录类别	SCI ; SCI
语种	英语
WOS记录号	WOS:000811389800006
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73846
专题	中国西南野生生物种质资源库
通讯作者	Li, Fei
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Lab Metabol & Drug Induced Liver Injury, Chengdu 610041, Peoples R China 4.Sichuan Univ, Inst Rare Dis, West China Hosp, Chengdu 610041, Peoples R China 5.Sichuan Univ, Sichuan Univ Univ Oxford Huaxi Joint Ctr Gastroin, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network,Dept Ga, Chengdu 610041, Peoples R China
推荐引用方式 GB/T 7714	Dai, Manyun,Peng, Wan,Zhang, Ting,et al. Metabolomics reveals the role of PPAR alpha in Tripterygium Wilfordii-induced liver injury[J]. JOURNAL OF ETHNOPHARMACOLOGY,2022,289:16.
APA	Dai, Manyun.,Peng, Wan.,Zhang, Ting.,Zhao, Qi.,Ma, Xiaofang.,...&Li, Fei.(2022).Metabolomics reveals the role of PPAR alpha in Tripterygium Wilfordii-induced liver injury.JOURNAL OF ETHNOPHARMACOLOGY,289,16.
MLA	Dai, Manyun,et al."Metabolomics reveals the role of PPAR alpha in Tripterygium Wilfordii-induced liver injury".JOURNAL OF ETHNOPHARMACOLOGY 289(2022):16.