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Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 227, 页码: 113966
Authors:  Wang,Yi-Ting;  Long,Xin-Yan;  Ding,Xiao;  Fan,Shi-Rui;  Cai,Jie-Yun;  Yang,Bi-Juan;  Zhang,Xin-Fang;  Luo,Rong-hua;  Yang,Lian;  Ruan,Ting;  Ren,Juan;  Jing,Chen-Xu;  Zheng,Yong-Tang;  Hao,Xiao-Jiang;  Chen,Duo-Zhi
Favorite  |  View/Download:27/0  |  Submit date:2022/04/02
Phenanthridine  Nucleocapsid protein  SARS-CoV-2  N-terminal domain  N-TERMINAL DOMAIN  CORONAVIRUS  
A Cryptic Plant Terpene Cyclase Producing Unconventional 18-and 14-Membered Macrocyclic C-25 and C-20 Terpenoids with Immunosuppressive Activity 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 卷号: 60, 期号: 48, 页码: 25468-25476
Authors:  Chen,Yue-Gui;  Li,De-Sen;  Ling,Yi;  Liu,Yan-Chun;  Zuo,Zhi-Li;  Gan,Li-She;  Luo,Shi-Hong;  Hua,Juan;  Chen,Ding-Yuan;  Xu,Fan;  Li,Man;  Guo,Kai;  Liu,Yan;  Gershenzon,Jonathan;  Li,Sheng-Hong
Favorite  |  View/Download:13/0  |  Submit date:2022/04/02
enzyme engineering  immunosuppressive activity  Leucosceptrum canum  macrocyclic terpenoids  sesterterpene synthase  GERANYLFARNESYL DIPHOSPHATE SYNTHASE  GLANDULAR TRICHOMES  LEUCOSCEPTRUM-CANUM  SCALE INSECT  SESTERTERPENOIDS  CONVERSION  EVOLUTION  PRECURSOR  HARBOR  
An extremely promiscuous terpenoid synthase from the Lamiaceae plant Colquhounia coccinea var. mollis catalyzes the formation of sester-/di-/sesqui-/mono-terpenoids 期刊论文
PLANT COMMUNICATIONS, 2021, 卷号: 2, 期号: 5, 页码: 100233
Authors:  Li,De-Sen;  Hua,Juan;  Luo,Shi-Hong;  Liu,Yan-Chun;  Chen,Yue-Gui;  Ling,Yi;  Guo,Kai;  Liu,Yan;  Li,Sheng-Hong
Favorite  |  View/Download:14/0  |  Submit date:2022/04/02
terpenoid diversity  terpenoid synthase  promiscuous enzyme  sester-/di-/sesqui-/mono-terpenoids  Colquhounia coccinea var  mollis  GERANYLFARNESYL DIPHOSPHATE SYNTHASE  GLANDULAR TRICHOMES  DITERPENE SYNTHASE  LEUCOSCEPTRUM-CANUM  IDENTIFICATION  BRASSICACEAE  BIOLOGY  FAMILY  HARBOR  GENES  
Characterization of defensive cadinenes and a novel sesquiterpene synthase responsible for their biosynthesis from the invasive Eupatorium adenophorum 期刊论文
NEW PHYTOLOGIST, 2021, 卷号: 229, 期号: 3, 页码: 1740-1754
Authors:  Liu,Yan;  Luo,Shi-Hong;  Hua,Juan;  Li,De-Sen;  Ling,Yi;  Luo,Qian;  Li,Sheng-Hong
Favorite  |  View/Download:10/0  |  Submit date:2022/04/02
cadinenes  defensive chemicals  Eupatorium adenophorum  sesquiterpenes  sesquiterpene synthase  NATURAL-PRODUCTS  FUNCTIONAL-CHARACTERIZATION  ABSOLUTE STEREOCHEMISTRY  TERPENE SYNTHASES  EXPRESSION  CLONING  EMISSION  LEAVES  GENES  9-OXO-10,11-DEHYDROAGERAPHORONE  
Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans 期刊论文
ORGANIC LETTERS, 2021, 卷号: 23, 期号: 19, 页码: 7462-7466
Authors:  Hua,Juan;  Liu,Yan-Chun;  Luo,Shi-Hong;  Liu,Yan;  Xiao,Chao-Jiang;  Li,Xiao-Nian;  Li,Sheng-Hong
Favorite  |  View/Download:9/0  |  Submit date:2022/04/02
QUILLAJA-SAPONARIA  BIOSYNTHESIS  MECHANISMS  ADJUVANTS  VARIANTS  PRODUCTS  CYCLASE  
Effects of 23-epi-26-deoxyactein on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity in C57BL/6 mice 期刊论文
PHYTOMEDICINE, 2020
Authors:  Yuan, Jingjing;  Shi, Qiangqiang;  Chen, Juan;  Lu, Jing;  Wang, Lu;  Qiu, Minghua;  Liu, Jian
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Peltate glandular trichomes of Colquhounia vestita harbor diterpenoid acids that contribute to plant adaptation to UV radiation and cold stresses 期刊论文
PHYTOCHEMISTRY, 2020
Authors:  Tang, Ting;  Li, Chun-Huan;  Li, De-Sen;  Jing, Shu-Xi;  Hua, Juan;  Luo, Shi-Hong;  Liu, Yan;  Li, Sheng-Hong
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Characterization of defensive cadinenes and a novel sesquiterpene synthase responsible for their biosynthesis from the invasive Eupatorium adenophorum 期刊论文
NEW PHYTOLOGIST, 2020
Authors:  Liu, Yan;  Luo, Shi-Hong;  Hua, Juan;  Li, De-Sen;  Ling, Yi;  Luo, Qian;  Li, Sheng-Hong
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Design, Synthesis, and Anticancer Activity of Novel Trimethoxyphenyl-Derived Chalcone-Benzimidazolium Salts 期刊论文
ACS OMEGA, 2019, 卷号: 4, 期号: 23, 页码: 20381-20393
Authors:  Yang, Jun-Li;  Ma, Yong-Hui;  Li, Yan-Hua;  Zhang, Yi-Peng;  Tian, Hong-Chang;  Huang, Yuan-Cheng;  Li, Yan;  Chen, Wen;  Yang, Li-Juan
View  |  Adobe PDF(2215Kb)  |  Favorite  |  View/Download:92/21  |  Submit date:2020/03/18
Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis 期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2019, 卷号: 17, 期号: 12, 页码: 892-899
Authors:  Ling Yi;  Teng Lin-Lin;  Hua Juan;  Li De-Sen;  Luo Shi-Hong;  Liu Yan-Chun;  Liu Yan;  Li Sheng-Hong
View  |  Adobe PDF(1517Kb)  |  Favorite  |  View/Download:133/12  |  Submit date:2020/03/18
Sesterterpenoid  Leucosceptroid B  Leucosceptrum canum  Caenorhabditis elegans  Fat accumulation  Fatty acid biosynthesis  Antilipemic agent