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Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans
Hua,Juan; Liu,Yan-Chun; Luo,Shi-Hong; Liu,Yan; Xiao,Chao-Jiang; Li,Xiao-Nian; Li,Sheng-Hong
2021
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume23Issue:19Pages:7462-7466
AbstractTwo novel triterpenoid saponins, colqueleganoids A (1) and B (2), with the first methyl-30 incorporated 6/6/6/6-cyclized carbon skeleton (named colquelegane), were isolated from the root of Colquhounia elegans. Their structures including absolute configuration were determined by spectroscopic methods and X-ray crystallographic analyses. Interestingly, both compounds significantly enhanced TNF-alpha production and 1 also increased the IL-6 production in RAW264.7 macrophages stimulated with lipopolysaccharide (LPS), suggesting their potential application as immunostimulants in immunotherapy and vaccination.
KeywordQUILLAJA-SAPONARIA BIOSYNTHESIS MECHANISMS ADJUVANTS VARIANTS PRODUCTS CYCLASE
DOI10.1021/acs.orglett.1c02673
WOS IDWOS:000704710800028
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73514
Collection中国科学院昆明植物研究所
Affiliation1.[Hua, Juan
2.Luo, Shi-Hong
3.Liu, Yan
4.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China
5.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China
6.Shenyang Agr Univ, Coll Biosci & Biotechnol, Shenyang 110866, Peoples R China
7.[Liu, Yan-Chun
8.Xiao, Chao-Jiang
9.Li, Xiao-Nian
10.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
11.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Hua,Juan,Liu,Yan-Chun,Luo,Shi-Hong,et al. Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans[J]. ORGANIC LETTERS,2021,23(19):7462-7466.
APA Hua,Juan.,Liu,Yan-Chun.,Luo,Shi-Hong.,Liu,Yan.,Xiao,Chao-Jiang.,...&Li,Sheng-Hong.(2021).Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans.ORGANIC LETTERS,23(19),7462-7466.
MLA Hua,Juan,et al."Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans".ORGANIC LETTERS 23.19(2021):7462-7466.
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