Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans

doi:10.1021/acs.orglett.1c02673

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	Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans
	Hua,Juan ; Liu,Yan-Chun ; Luo,Shi-Hong ; Liu,Yan ; Xiao,Chao-Jiang ; Li,Xiao-Nian ; Li,Sheng-Hong
	2021
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	23 期号:19 页码:7462-7466
摘要	Two novel triterpenoid saponins, colqueleganoids A (1) and B (2), with the first methyl-30 incorporated 6/6/6/6-cyclized carbon skeleton (named colquelegane), were isolated from the root of Colquhounia elegans. Their structures including absolute configuration were determined by spectroscopic methods and X-ray crystallographic analyses. Interestingly, both compounds significantly enhanced TNF-alpha production and 1 also increased the IL-6 production in RAW264.7 macrophages stimulated with lipopolysaccharide (LPS), suggesting their potential application as immunostimulants in immunotherapy and vaccination.
关键词	QUILLAJA-SAPONARIA BIOSYNTHESIS MECHANISMS ADJUVANTS VARIANTS PRODUCTS CYCLASE
DOI	10.1021/acs.orglett.1c02673
WOS记录号	WOS:000704710800028
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73514
专题	中国科学院昆明植物研究所
作者单位	1.[Hua, Juan 2.Luo, Shi-Hong 3.Liu, Yan 4.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 5.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 6.Shenyang Agr Univ, Coll Biosci & Biotechnol, Shenyang 110866, Peoples R China 7.[Liu, Yan-Chun 8.Xiao, Chao-Jiang 9.Li, Xiao-Nian 10.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 11.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Hua,Juan,Liu,Yan-Chun,Luo,Shi-Hong,et al. Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans[J]. ORGANIC LETTERS,2021,23(19):7462-7466.
APA	Hua,Juan.,Liu,Yan-Chun.,Luo,Shi-Hong.,Liu,Yan.,Xiao,Chao-Jiang.,...&Li,Sheng-Hong.(2021).Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans.ORGANIC LETTERS,23(19),7462-7466.
MLA	Hua,Juan,et al."Immunostimulatory 6/6/6/6 Tetracyclic Triterpenoid Saponins with the Methyl-30 Incorporated Cyclization from the Root of Colquhounia elegans".ORGANIC LETTERS 23.19(2021):7462-7466.

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