Labdane diterpenoids from the heartwood of Leucosceptrum canum that impact on root growth and seed germination of Arabidopsis thaliana

doi:10.1016/j.phytochem.2022.113531

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	Labdane diterpenoids from the heartwood of Leucosceptrum canum that impact on root growth and seed germination of Arabidopsis thaliana
	Liu,Yan; Zhou,Yan-Ying; Luo,Shi-Hong; Guo,Kai; Zhang,Man-Wen; Jing,Shu-Xi; Li,Chun-Huan; Hua,Juan; Li,Sheng-Hong
	2023
发表期刊	PHYTOCHEMISTRY
ISSN	1873-3700
卷号	206 页码:113531
摘要	Eleven undescribed diterpenoids possessing labdane, 3,18-cyclo-labdane, 19 (4 -> 3)-labdane and 12-nor-labdane skeletons, named leucolactones A-K, were isolated from the heartwood of a large woody Lamiaceae plant, Leucosceptrum canum. Their structures were determined by NMR, MS, and in the case of leucolactones A by single crystal X-ray diffraction analysis. Plausible biosynthetic pathway of leucolactones were proposed. Leucolactones showed significant inhibitory effects against seed germination and root elongation of Arabidopsis thaliana in the Petri dish bioassay. Among them, the diastereomeric leucolactones G and H were the most potent, with EC50 values for root elongation of 6.53 +/- 1.35 and 9.75 +/- 1.25 mu M, respectively. The preliminary structure-activity relationship of leucolactones was discussed. The increase of auxin reporter activity in A. thaliana DR5::GUS roots by leucolactone H was observed, indicating that leucolactones altered auxin accumulation and distribution. These findings suggested that leucolactones might be involved in regulation of plant growth and development through altering auxin accumulation and distribution, presumably contributing to the heartwood formation in L. canum.
关键词	Leucosceptrum canum Lamiaceae Labdane diterpenoids Leucolactones A-K Phytotoxic activity Auxin accumulation GLANDULAR TRICHOMES COLORED NECTAR AUXIN TRANSPORT GRADIENT WOOD
学科领域	Biochemistry & Molecular Biology ; Plant Sciences
DOI	10.1016/j.phytochem.2022.113531
收录类别	SCI
WOS记录号	WOS:000903504400013
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75431
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Liu,Yan,Zhou,Yan-Ying,Luo,Shi-Hong,et al. Labdane diterpenoids from the heartwood of Leucosceptrum canum that impact on root growth and seed germination of Arabidopsis thaliana[J]. PHYTOCHEMISTRY,2023,206:113531.
APA	Liu,Yan.,Zhou,Yan-Ying.,Luo,Shi-Hong.,Guo,Kai.,Zhang,Man-Wen.,...&Li,Sheng-Hong.(2023).Labdane diterpenoids from the heartwood of Leucosceptrum canum that impact on root growth and seed germination of Arabidopsis thaliana.PHYTOCHEMISTRY,206,113531.
MLA	Liu,Yan,et al."Labdane diterpenoids from the heartwood of Leucosceptrum canum that impact on root growth and seed germination of Arabidopsis thaliana".PHYTOCHEMISTRY 206(2023):113531.

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