Matrine-Type Alkaloids with Anti-Tomato Spotted Wilt Virus Activity from the Root of Sophora tonkinensis Gagnep.

doi:10.1021/acs.jafc.2c09003

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	Matrine-Type Alkaloids with Anti-Tomato Spotted Wilt Virus Activity from the Root of Sophora tonkinensis Gagnep.
	Zhao,Li-Hua; Hu,Zhan-Xing; Hao,Xiao-Jiang; Zhang,Peng; Zhang,Ji; An,Qiao; Wang,Juan; Yi,Ping; Yuan,Chun-Mao; Zhang,Zhong-Kai
	2023
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	1520-5118
卷号	71 期号:10 页码:4394-4407
摘要	As a continuation of our research on the development of pesticide active quinolizidine alkaloids (QAs) from the family Fabaceae, the chemical constituents of the root of Sophora tonkinensis Gagnep. were systematically investigated. Seventeen new matrine-type alkaloids (1-17), including one new naturally occurring compound (17), along with 20 known ones were isolated from the EtOH extract of S. tonkinensis. Notably, compound 5 possessed an unprecedented 6/6/5/4/6/6 hexacyclic system. Their structures were confirmed via comprehensive spectroscopic data analysis (IR, UV, NMR, HRESIMS), ECD calculation, and X-ray crystallography. Biological tests indicated that compounds 1, 4, 10, 12, 13, and 30 displayed significant anti-tomato spotted wilt virus (TSWV) activities compared with the positive control ningnanmycin. Moreover, compound 12 strongly inhibited the expression of the TSWV N, NSs, and NSm genes and TSWV NSs protein in plant host. Furthermore, compounds 4, 10, 12, 20, and 22 exhibited moderate insecticidal activities against TSWV thrip vector (Frankliniella occidentalis).
关键词	Sophora tonkinensis Gagnep matrine-type alkaloids anti-TSWV LUPIN ALKALOIDS QUINOLIZIDINE ALKALOIDS SEEDS
学科领域	Agriculture ; Chemistry ; Food Science & Technology
DOI	10.1021/acs.jafc.2c09003
收录类别	SCI
WOS记录号	WOS:000942360700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75302
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhao,Li-Hua,Hu,Zhan-Xing,Hao,Xiao-Jiang,et al. Matrine-Type Alkaloids with Anti-Tomato Spotted Wilt Virus Activity from the Root of Sophora tonkinensis Gagnep.[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2023,71(10):4394-4407.
APA	Zhao,Li-Hua.,Hu,Zhan-Xing.,Hao,Xiao-Jiang.,Zhang,Peng.,Zhang,Ji.,...&Zhang,Zhong-Kai.(2023).Matrine-Type Alkaloids with Anti-Tomato Spotted Wilt Virus Activity from the Root of Sophora tonkinensis Gagnep..JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,71(10),4394-4407.
MLA	Zhao,Li-Hua,et al."Matrine-Type Alkaloids with Anti-Tomato Spotted Wilt Virus Activity from the Root of Sophora tonkinensis Gagnep.".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 71.10(2023):4394-4407.

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