Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity

doi:10.1016/j.phytochem.2021.112961

KIB OpenIR

	Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity
	Guo,Kai ; Zhou,Ting-Ting ; Ren,Xue ; Li,Dan ; Hu,Hong; Liu,Yan-Chun ; Liu,Yan ; Li,Sheng-Hong
	2021
Source Publication	PHYTOCHEMISTRY
ISSN	0031-9422
Volume	192 Pages:112961
Abstract	Two undescribed secoiridoids (dehydroxyl-swerimilegenin H and 9-oxo-swerimuslactone A) with eight known ones, and two undescribed triterpenoids [28-O-(3,4-dihydroxyl-benzyl)-lupeol and 17-hydroperoxide-28-norurs12-en-3-one] with seven known ones, were isolated from the aerial parts of Gentiana veitchiorum, a traditional Tibetan medicine. The structures of these compounds were elucidated by detailed spectroscopic analyses (including 1D and 2D NMR, HRMS, IR, and specific rotation) and comparison with structurally related known compounds. The isolates were selected to evaluate for their immunosuppressive activity via inhibiting the proliferation of T cells and cytokine IFN-gamma production in T cells. Among them, 28-O-(3,4-dihydroxyl-benzyl)-lupeol exhibited significant effect by inhibiting the proliferation of T cells (IC50, 20.08 mu M) and T cell IFN-gamma production (IC50, 7.29 mu M).
Keyword	Gentiana veitchiorum Gentianaceae Secoiridoids Triterpenoids Immunosuppressive activity CONSTITUENTS HEMSL.
DOI	10.1016/j.phytochem.2021.112961
WOS ID	WOS:000704441000014
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73516
Collection	中国科学院昆明植物研究所
Affiliation	1.[Guo, Kai 2.Ren, Xue 3.Hu, Hong 4.Liu, Yan 5.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China 6.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China 7.[Zhou, Ting-Ting 8.Li, Dan 9.Liu, Yan-Chun 10.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 11.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Guo,Kai,Zhou,Ting-Ting,Ren,Xue,et al. Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity[J]. PHYTOCHEMISTRY,2021,192:112961.
APA	Guo,Kai.,Zhou,Ting-Ting.,Ren,Xue.,Li,Dan.,Hu,Hong.,...&Li,Sheng-Hong.(2021).Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity.PHYTOCHEMISTRY,192,112961.
MLA	Guo,Kai,et al."Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity".PHYTOCHEMISTRY 192(2021):112961.

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