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Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity
Guo,Kai; Zhou,Ting-Ting; Ren,Xue; Li,Dan; Hu,Hong; Liu,Yan-Chun; Liu,Yan; Li,Sheng-Hong
2021
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号192页码:112961
摘要Two undescribed secoiridoids (dehydroxyl-swerimilegenin H and 9-oxo-swerimuslactone A) with eight known ones, and two undescribed triterpenoids [28-O-(3,4-dihydroxyl-benzyl)-lupeol and 17-hydroperoxide-28-norurs12-en-3-one] with seven known ones, were isolated from the aerial parts of Gentiana veitchiorum, a traditional Tibetan medicine. The structures of these compounds were elucidated by detailed spectroscopic analyses (including 1D and 2D NMR, HRMS, IR, and specific rotation) and comparison with structurally related known compounds. The isolates were selected to evaluate for their immunosuppressive activity via inhibiting the proliferation of T cells and cytokine IFN-gamma production in T cells. Among them, 28-O-(3,4-dihydroxyl-benzyl)-lupeol exhibited significant effect by inhibiting the proliferation of T cells (IC50, 20.08 mu M) and T cell IFN-gamma production (IC50, 7.29 mu M).
关键词Gentiana veitchiorum Gentianaceae Secoiridoids Triterpenoids Immunosuppressive activity CONSTITUENTS HEMSL.
DOI10.1016/j.phytochem.2021.112961
WOS记录号WOS:000704441000014
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/73516
专题中国科学院昆明植物研究所
作者单位1.[Guo, Kai
2.Ren, Xue
3.Hu, Hong
4.Liu, Yan
5.Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China
6.Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China
7.[Zhou, Ting-Ting
8.Li, Dan
9.Liu, Yan-Chun
10.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
11.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
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GB/T 7714
Guo,Kai,Zhou,Ting-Ting,Ren,Xue,et al. Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity[J]. PHYTOCHEMISTRY,2021,192:112961.
APA Guo,Kai.,Zhou,Ting-Ting.,Ren,Xue.,Li,Dan.,Hu,Hong.,...&Li,Sheng-Hong.(2021).Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity.PHYTOCHEMISTRY,192,112961.
MLA Guo,Kai,et al."Secoiridoids and triterpenoids from the traditional Tibetan medicine Gentiana veitchiorum and their immunosuppressive activity".PHYTOCHEMISTRY 192(2021):112961.
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