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YC-1 inhibits proliferation of breast cancer cells by downregulating EZH2 expression via activation of c-Cbl and ERK 期刊论文
出版物, 3111, 期号: 0, 页码: 1-46
Authors:  Ling-Chu Chang;  Hui-Yi Lin;  Meng-Tung Tsai;  Ruey-Hwang Chou;  Fang-Yu Lee;  Che-Ming Teng;  Min-Tsang Hsieh;  Hsin-Yi Hung;  Li-Jiau Huang;  Yung-Luen Yu;  Sheng-Chu Kuo
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Yc-1  Triple-negative Breast Cancer  Erk  Ezh2  C-cbl  
Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol derivatives as alpha-glucosidase and PTP1B inhibitors 期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2022, 卷号: 31, 期号: 2, 页码: 350-367
Authors:  Yang, Xiao-Tong;  Li, Tian-Ze;  Geng, Chang-An;  Liu, Pei;  Chen, Ji-Jun
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(20S,24R)-epoxy-dammarane-3 beta,12 beta,25-triol  alpha-glucosidase inhibitors  PTP1B inhibitors  Enzyme kinetics  TYROSINE-PHOSPHATASE 1B  DIABETES-MELLITUS  EPIDEMIOLOGY  
Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity 期刊论文
PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY, 2022, 卷号: 91, 期号: 8, 页码: 1809-1816
Authors:  Luo, Shuaibin;  Zhang, Xuemei;  He, Kang;  Zou, Juan;  Geng, Chang-An
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Uncaria rhynchophylla  triterpenoids  antidiabetic effects  PTP1B inhibitors  ALKALOIDS  
多花蒿烯内酯H等三种萜类化合物 衍生物合成与抗肝癌和降血糖活性 学位论文
, 2021
Authors:  杨晓烔
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Structure Revision of Four Classes of Prenylated Aromatic Natural Products Based on a Rule for Diagnostic C-13 NMR Chemical Shifts 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 86, 期号: 16, 页码: 10982-10990
Authors:  Ren,Fu-Cai;  Wang,Li-Xia;  Lv,Yong-Feng;  Hu,Jiang-Miao;  Zhou,Jun
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ISOPRENYLATED FLAVONOIDS  CONSTITUENTS  DERIVATIVES  ANALOGS  
Diarylheptanoid-flavanone Hybrids as Multiple-target Antidiabetic Agents from Alpinia katsumadai 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2021, 卷号: 39, 期号: 11, 页码: 3051-3063
Authors:  He,Xiao-Feng;  Chen,Ji-Jun;  Li,Tian-Ze;  Hu,Jing;  Huang,Xiao-Yan;  Zhang,Xue-Mei;  Guo,Yuan-Qiang;  Geng,Chang-An
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Alpinia katsumadai  Katsumadainols B-1-B-15  Natural products  Structure elucidation  Biological activity  TYROSINE-PHOSPHATASE 1B  GLYCOGEN-PHOSPHORYLASE  ALPHA-GLUCOSIDASE  ABSOLUTE-CONFIGURATION  STRUCTURE ELUCIDATION  DUAL INHIBITION  SEEDS  CONSTITUENT  DERIVATIVES  CHALCONE  
Six New 3,5-Dimethylcoumarins from Chelonopsis praecox, Chelonopsis odontochila and Chelonopsis pseudobracteata. 期刊论文
Natural products and bioprospecting, 2021, 卷号: 11, 期号: 6, 页码: 643-649
Authors:  Geng,Chang-An;  Deng,Zhen-Tao;  Huang,Qian;  Xiang,Chun-Lei;  Chen,Ji-Jun
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The antidiabetic potency of Amomum tsao-ko and its active flavanols, as PTP1B selective and alpha-glucosidase dual inhibitors 期刊论文
INDUSTRIAL CROPS AND PRODUCTS, 2021, 卷号: 160, 页码: 112908
Authors:  He,Xiao-Feng;  Chen,Ji-Jun;  Huang,Xiao-Yan;  Hu,Jing;  Zhang,Xu-Ke;  Guo,Yuan-Qiang;  Zhang,Xue-Mei;  Geng,Chang-An
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Amomum tsao-ko  Amomutsaokins A-H  Flavanol-menthane conjugates  PTP1B selective inhibitors  alpha-Glucosidase inhibitors  ANTIOXIDANT ACTIVITY  ESSENTIAL OIL  CONSTITUENTS  TANNINS  CREVOST  ACID  
Diarylheptanoid-chalcone hybrids with PTP1B and alpha-glucosidase dual inhibition from Alpinia katsumadai 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 108, 页码: 104683
Authors:  He,Xiao-Feng;  Chen,Ji-Jun;  Li,Tian-Ze;  Hu,Jing;  Zhang,Xue-Mei;  Geng,Chang-An
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Alpinia katsumadai  Katsumadainols A(1)-A(16)  PTP1B/TCPTP selective inhibitors  alpha-glucosidase inhibitors  Antidiabetic effects  THEORETICAL CALCULATION  ABSOLUTE-CONFIGURATION  SEEDS  BLEPHAROCALYXINS  ADDUCT  MOIETY  
Inositol polyphosphate multikinase IPMK-1 regulates development through IP3/calcium signaling in Caenorhabditis elegans 期刊论文
CELL CALCIUM, 2021, 卷号: 93, 页码: 102327
Authors:  Yang,Zhong-Lin;  Chen,Jian-Ning;  Lu,Yu-Yang;  Lu,Min;  Wan,Qin-Li;  Wu,Gui-Sheng;  Luo,Huai-Rong
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Inositol polyphosphates  Inositol polyphosphate multikinase  Type I inositol 5-phosphatase  Development  Calcium signaling  Defecation rhythm  C. elegans  C-ELEGANS  PHOSPHOLIPASE-C  CALCIUM  1,4,5-TRISPHOSPHATE  CALCINEURIN  KINASE  IDENTIFICATION  TRISPHOSPHATE  METABOLISM  RECEPTOR