Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity

doi:10.32604/phyton.2022.020935

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	Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity
	Luo, Shuaibin; Zhang, Xuemei; He, Kang; Zou, Juan; Geng, Chang-An
	2022
发表期刊	PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY
卷号	91 期号:8 页码:1809-1816
摘要	Uncaria rhynchophylla (Gouteng) is a famous traditional Chinese medicine used for psychiatric and hypotensive purposes in China. In this study, the ethyl acetate (EtOAc) part of U. rhynchophylla was revealed with protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. Subsequent investigation on the EtOAc part yielded one new triterpenoid, 313-formyloxy-613,19a-dihydroxyurs-12-en-28-oic acid (1) and four known ones, 313,613,19a-trihydroxyurs-12-en-28-oic acid (2), 2-oxopomolic acid (3), 313,19a-dihydroxy-6-oxo-olean-12-en-28-oic acid (4) and sumaresinolic acid (5). The structure of compound 1 was determined by extensive HRESIMS, IR, 1D and 2D NMR spectroscopic analyses. Two ursane-type triterpenoids (2 and 3) showed selective inhibition on PTP1B with IC50 values of 48.2 and 178.7 yM. The enzyme kinetic study suggested that compounds 2 and 3 were mixtype inhibitors on PTP1B with Ki values of 15.6 and 132.5 yM. This investigation manifests the antidiabetic potency of U. rhynchophylla with triterpenoids as the active constituents.
关键词	Uncaria rhynchophylla triterpenoids antidiabetic effects PTP1B inhibitors ALKALOIDS
DOI	10.32604/phyton.2022.020935
收录类别	SCI
WOS记录号	WOS:000789076500005
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/74790
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Luo, Shuaibin,Zhang, Xuemei,He, Kang,et al. Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity[J]. PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY,2022,91(8):1809-1816.
APA	Luo, Shuaibin,Zhang, Xuemei,He, Kang,Zou, Juan,&Geng, Chang-An.(2022).Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity.PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY,91(8),1809-1816.
MLA	Luo, Shuaibin,et al."Triterpenoids from Uncaria rhynchophylla and Their PTP1B Inhibitory Activity".PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY 91.8(2022):1809-1816.

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