Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway

doi:10.1016/j.heliyon.2023.e13691

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	Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway
	Ran,Xiaoqian; Lu,Qing-Yun; Li,Ying-Yao; Pu,Xue-Xue; Guo,Yarong; Yuan,Ming-Rui; Guan,Shi-Peng; Sun,Mao; Jiao,Lijin; Yao,Yong-Gang; Di,Ying-Tong; Hao,Xiao-Jiang; Luo,Rongcan
	2023
发表期刊	HELIYON
ISSN	2405-8440
卷号	9 期号:2 页码:e13691
摘要	A new ent-abietane diterpenoid, named Euphejolkinolide A (1), was isolated from the whole plant of Euphorbia peplus L. Its structure, including absolute configurations, was determined by spec-troscopic analyses and was corroborated by single-crystal X-ray diffraction analysis. This new compound was assessed for its activity to induce lysosome biogenesis through Lyso-Tracker Red staining, in which compound 1 could significantly induce lysosome biogenesis. In addition, quantitative real-time PCR (qRT-PCR) analysis demonstrated a direct correlation between the observed lysosome biogenesis and the transcriptional activation of the lysosomal genes after treatment with the compound 1. Moreover, compound 1 promoted autophagic flux by upregu-lating LC3-II and downregulating SQSTM1 in both human microglia cells and U251 cells, which is required for cellular homeostasis. Further results suggested 1 induced lysosome biogenesis and autophagy which was mediated by TFEB (transcription factor EB). The structure activity re-lationships (SAR) analysis suggested that the carbony1 at C-7 in 1 might be a key active group. Overall, the current data suggested that 1 could be a potential compound for lysosome disorder therapy by induction of autophagy.
关键词	Euphorbia peplus L Euphorbiaceae Ent-abietane diterpenoid Euphejolkinolide A Autophagy-lysosomal pathway ALZHEIMERS-DISEASE TAU PATHOLOGY NEURODEGENERATION DITERPENOIDS INHIBITION MECHANISMS APOPTOSIS CELASTROL PROTEIN SYSTEM
学科领域	Science & Technology - Other Topics
DOI	10.1016/j.heliyon.2023.e13691
收录类别	SCI
WOS记录号	WOS:000972987100001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75555
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Ran,Xiaoqian,Lu,Qing-Yun,Li,Ying-Yao,et al. Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway[J]. HELIYON,2023,9(2):e13691.
APA	Ran,Xiaoqian.,Lu,Qing-Yun.,Li,Ying-Yao.,Pu,Xue-Xue.,Guo,Yarong.,...&Luo,Rongcan.(2023).Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway.HELIYON,9(2),e13691.
MLA	Ran,Xiaoqian,et al."Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway".HELIYON 9.2(2023):e13691.

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