Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy

doi:10.1016/j.bioorg.2023.106375

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	Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy
	Peng,Xingrong; Luo,Rongcan; Ran,Xiaoqian; Guo,Yarong; Yao,Yong-Gang; Qiu,Minghua
	2023
发表期刊	BIOORGANIC CHEMISTRY
ISSN	1090-2120
卷号	132 页码:106375
摘要	Ganoapplins A and B (1 and 2) with a 6/6/6/5/6-fused pentacyclic skeleton containing an aromatic E ring, were obtained from Ganoderma applanatum. Their structures were established through extensive spectroscopic ana -lyses, quantum chemical calculations, including calculated chemical shifts with DP4 + analysis and electronic circular dichroism (ECD). A plausible biosynthetic pathway for 1 and 2 was proposed. Furthermore, their roles in activating autophagy were investigated and the cellular assays showed that 1 and 2 can inhibit tau pathology by inducing autophagy, suggesting their potential against Alzheimer's disease (AD).
关键词	Ganoderma Ganoderma applanatum Triterpenoid Autophagy Tau pathology Alzheimer?s disease LANOSTANE-TYPE TRITERPENOIDS ALZHEIMERS-DISEASE FRUITING BODIES NEURODEGENERATION ACID
学科领域	Biochemistry & Molecular Biology ; Chemistry
DOI	10.1016/j.bioorg.2023.106375
收录类别	SCI
WOS记录号	WOS:000925324500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75479
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Peng,Xingrong,Luo,Rongcan,Ran,Xiaoqian,et al. Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy[J]. BIOORGANIC CHEMISTRY,2023,132:106375.
APA	Peng,Xingrong,Luo,Rongcan,Ran,Xiaoqian,Guo,Yarong,Yao,Yong-Gang,&Qiu,Minghua.(2023).Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy.BIOORGANIC CHEMISTRY,132,106375.
MLA	Peng,Xingrong,et al."Ganoapplins A and B with an unprecedented 6/6/6/5/6-fused pentacyclic skeleton from Ganoderma inhibit Tau pathology through activating autophagy".BIOORGANIC CHEMISTRY 132(2023):106375.

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