Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy

doi:10.1039/d2ob01965e

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	Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy
	Yan,Ying; Ran,Xiaoqian; Wang,Dan; Zhang,Xiong; Peng,Mingyou; Yan,Xiaoyan; Tang,Lei; Liang,Hong; Qin,Xujie; Di,Ying-Tong; Luo,Rongcan; Hao,Xiao-Jiang; Yao,Yong-Gang
	2023
发表期刊	ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN	1477-0539
卷号	21 期号:3 页码:514-519
摘要	Munronin V (1), isolated from Munronia henryi Harms, is the first example, to the best of our knowledge, of an unprecedented 7/7/6 tricarbocyclic framework featuring an unusual A,B-seco-limonoid ring. The structures of munronin V were established from extensive spectroscopic and electronic circular dichroism (ECD) analyses. The novel A,B-seco with two seven-membered lactones was formed as a result of Baeyer-Villiger oxidation. Compound 1 activated autophagy and inhibited Tau pathology as revealed by flow cytometric analyses, confocal imaging analysis and western blotting, and this effect was mediated by transcription factor EB (TFEB). These findings suggested that 1 might have potential as a compound for combating Alzheimer's disease.
关键词	UBIQUITIN-PROTEASOME SYSTEM ALZHEIMERS-DISEASE CONSTITUENTS LIMONOIDS TFEB NEURODEGENERATION
学科领域	Chemistry
DOI	10.1039/d2ob01965e
收录类别	SCI
WOS记录号	WOS:000906757600001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75544
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Yan,Ying,Ran,Xiaoqian,Wang,Dan,et al. Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2023,21(3):514-519.
APA	Yan,Ying.,Ran,Xiaoqian.,Wang,Dan.,Zhang,Xiong.,Peng,Mingyou.,...&Yao,Yong-Gang.(2023).Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy.ORGANIC & BIOMOLECULAR CHEMISTRY,21(3),514-519.
MLA	Yan,Ying,et al."Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy".ORGANIC & BIOMOLECULAR CHEMISTRY 21.3(2023):514-519.

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