Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy

doi:10.1039/d2ob01965e

KIB OpenIR

	Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy
	Yan,Ying; Ran,Xiaoqian; Wang,Dan; Zhang,Xiong; Peng,Mingyou; Yan,Xiaoyan; Tang,Lei; Liang,Hong; Qin,Xujie; Di,Ying-Tong; Luo,Rongcan; Hao,Xiao-Jiang; Yao,Yong-Gang
	2023
Source Publication	ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN	1477-0539
Volume	21 Issue:3 Pages:514-519
Abstract	Munronin V (1), isolated from Munronia henryi Harms, is the first example, to the best of our knowledge, of an unprecedented 7/7/6 tricarbocyclic framework featuring an unusual A,B-seco-limonoid ring. The structures of munronin V were established from extensive spectroscopic and electronic circular dichroism (ECD) analyses. The novel A,B-seco with two seven-membered lactones was formed as a result of Baeyer-Villiger oxidation. Compound 1 activated autophagy and inhibited Tau pathology as revealed by flow cytometric analyses, confocal imaging analysis and western blotting, and this effect was mediated by transcription factor EB (TFEB). These findings suggested that 1 might have potential as a compound for combating Alzheimer's disease.
Keyword	UBIQUITIN-PROTEASOME SYSTEM ALZHEIMERS-DISEASE CONSTITUENTS LIMONOIDS TFEB NEURODEGENERATION
Subject Area	Chemistry
DOI	10.1039/d2ob01965e
Indexed By	SCI
WOS ID	WOS:000906757600001
Citation statistics	Cited Times:3[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/75544
Collection	中国科学院昆明植物研究所
Recommended Citation GB/T 7714	Yan,Ying,Ran,Xiaoqian,Wang,Dan,et al. Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2023,21(3):514-519.
APA	Yan,Ying.,Ran,Xiaoqian.,Wang,Dan.,Zhang,Xiong.,Peng,Mingyou.,...&Yao,Yong-Gang.(2023).Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy.ORGANIC & BIOMOLECULAR CHEMISTRY,21(3),514-519.
MLA	Yan,Ying,et al."Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy".ORGANIC & BIOMOLECULAR CHEMISTRY 21.3(2023):514-519.

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