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Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy
Yan,Ying; Ran,Xiaoqian; Wang,Dan; Zhang,Xiong; Peng,Mingyou; Yan,Xiaoyan; Tang,Lei; Liang,Hong; Qin,Xujie; Di,Ying-Tong; Luo,Rongcan; Hao,Xiao-Jiang; Yao,Yong-Gang
2023
发表期刊ORGANIC & BIOMOLECULAR CHEMISTRY
ISSN1477-0539
卷号21期号:3页码:514-519
摘要Munronin V (1), isolated from Munronia henryi Harms, is the first example, to the best of our knowledge, of an unprecedented 7/7/6 tricarbocyclic framework featuring an unusual A,B-seco-limonoid ring. The structures of munronin V were established from extensive spectroscopic and electronic circular dichroism (ECD) analyses. The novel A,B-seco with two seven-membered lactones was formed as a result of Baeyer-Villiger oxidation. Compound 1 activated autophagy and inhibited Tau pathology as revealed by flow cytometric analyses, confocal imaging analysis and western blotting, and this effect was mediated by transcription factor EB (TFEB). These findings suggested that 1 might have potential as a compound for combating Alzheimer's disease.
关键词UBIQUITIN-PROTEASOME SYSTEM ALZHEIMERS-DISEASE CONSTITUENTS LIMONOIDS TFEB NEURODEGENERATION
学科领域Chemistry
DOI10.1039/d2ob01965e
收录类别SCI
WOS记录号WOS:000906757600001
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/75544
专题中国科学院昆明植物研究所
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Yan,Ying,Ran,Xiaoqian,Wang,Dan,et al. Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2023,21(3):514-519.
APA Yan,Ying.,Ran,Xiaoqian.,Wang,Dan.,Zhang,Xiong.,Peng,Mingyou.,...&Yao,Yong-Gang.(2023).Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy.ORGANIC & BIOMOLECULAR CHEMISTRY,21(3),514-519.
MLA Yan,Ying,et al."Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy".ORGANIC & BIOMOLECULAR CHEMISTRY 21.3(2023):514-519.
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