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UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations Eph antagonist and angiogenesis 期刊论文
出版物, 3111, 期号: 0, 页码: 1-32
Authors:  I Hassan-Mohamed;  C Giorgio;  M Incerti;  S Russo;  D Pala;  E B Pasquale;  P Vicini;  E Barocelli;  S Rivara;  M Mor;  A Lodola;  M Tognolini
Adobe PDF(1403Kb)  |  Favorite  |  View/Download:117/1  |  Submit date:2017/07/24
Eph Kinase  Ephrin  Small Molecules  Angiogenesis  Bile Acid  Lithocholic Acid  
ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells1 期刊论文
出版物, 3111, 期号: 0, 页码: 1-35
Authors:  Jingru Li;  Yicheng Chen;  Jiali Wan;  Xin Liu;  Chunrong Yu;  Wenhua Li
Adobe PDF(1198Kb)  |  Favorite  |  View/Download:33/1  |  Submit date:2017/07/24
Abt-263  Sorafenib  Combination Therapy  Cancer  
Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 93, 页码: 13
Authors:  Zhou, Yeheng;  Sun, Wei;  Peng, Jiale;  Yan, Hui;  Zhang, Li;  Liu, Xingyong;  Zuo, Zhili
View  |  Adobe PDF(4739Kb)  |  Favorite  |  View/Download:18/4  |  Submit date:2020/03/18
Acetylcholinesterase  Drug design  N-acylhydrazone  Dementia  Copper-chelating  N-Benzylpiperidine  
Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2162-2178
Authors:  Zhao, Qi;  Zhang, Ting;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Wang, Yan;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(3915Kb)  |  Favorite  |  View/Download:41/1  |  Submit date:2019/07/29
B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
Authors:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
View  |  Adobe PDF(5225Kb)  |  Favorite  |  View/Download:66/0  |  Submit date:2019/06/24
Spirocyclic polycyclic polyprenylated acylphloroglucinols from the ethyl acetate fraction of Hypericum henryi 期刊论文
TETRAHEDRON LETTERS, 2018, 卷号: 59, 期号: 46, 页码: 4067-4072
Authors:  Duan, Yao-Tao;  Zhang, Juan;  Lao, Yuan-Zhi;  Tan, Hong-Sheng;  Ye, Yan-Song;  Yang, Xing-Wei;  Xu, Hong-Xi;  Xu, Gang
View  |  Adobe PDF(895Kb)  |  Favorite  |  View/Download:371/84  |  Submit date:2018/12/18
Polyprenylated Acylphloroglucinol  Hyperhenones G-m  Hypericum Henryi  Spirocyclic  Antitumor  
Virtual screening of B-Raf kinase inhibitors: A combination of pharmacophore modelling, molecular docking, 3D-QSAR model and binding free energy calculation studies 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2017, 卷号: 70, 页码: 186-190
Authors:  Zhang, Wen;  Qiu, Kai-Xiong;  Yu, Fang;  Xie, Xiao-Guang;  Zhang, Shu-Qun;  Chen, Ya-Juan;  Xie, Hui-Ding
View  |  Adobe PDF(371Kb)  |  Favorite  |  View/Download:60/3  |  Submit date:2017/12/11
B-raf Kinase Inhibitors  Virtual Screening  Pharmacophore  Molecular Docking  3d Qsar  Binding Free Energy Calculation  
USP7 作为结直肠肿瘤治疗靶点的研究 学位论文
: 中国科学院大学, 2017
Authors:  安涛
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三种马鞭草科植物和有柄树舌萜类化学成分及生物活性研究 学位论文
: 中国科学院大学, 2017
Authors:  普德兵
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Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 50, 页码: 82820-82835
Authors:  Zhou, Xunian;  Yue, Grace Gar-Lee;  Liu, Minghua;  Zuo, Zhili;  Lee, Julia Kin-Ming;  Li, Mingyue;  Tsui, Stephen Kwok-Wing;  Fung, Kwok-Pui;  Sun, Handong;  Pu, Jianxin;  Lau, Clara Bik-San
View  |  Adobe PDF(13632Kb)  |  Favorite  |  View/Download:147/9  |  Submit date:2017/02/28
Eriocalyxin b  Angiogenesis  Vascular Endothelial Growth Factor (Vegf)  Vascular Endothelial Growth Factor Receptor 2(Vegfr-2)  Breast Cancer