Artemdubinoids A-N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia

doi:10.1016/S1875-5364(23)60441-8

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	Artemdubinoids A-N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia
	Gao,Zhen; Li,Tianze; Ma,Yunbao; Huang,Xiaoyan; Geng,Changan; Zhang,Xuemei; Chen,Jijun
	2023
Source Publication	CHINESE JOURNAL OF NATURAL MEDICINES
ISSN	1875-5364
Volume	21 Issue:12 Pages:902-915
Abstract	In pursuit of effective agents for hepatocellular carcinoma derived from the Artemisia species, this study built upon initial findings that an ethanol (EtOH) extract and ethyl acetate (EtOAc) fraction of the aerial parts of Artemisia dubia Wall. ex Bess. ex-hibited cytotoxicity against HepG2 cells with inhibitory rates of 57.1% and 84.2% (100 mu g center dot mL-1), respectively. Guided by bioactivity, fourteen previously unidentified sesquiterpenes, artemdubinoids A-N (1-14), were isolated from the EtOAc fraction. Their structural elucidation was achieved through comprehensive spectroscopic analyses and corroborated by the comparison between the experiment-al and calculated ECD spectra. Single crystal X-ray diffraction provided definitive structure confirmation for artemdubinoids A, D, F, and H. Artemdubinoids A and B (1-2) represented unique sesquiterpenes featuring a 6/5-fused bicyclic carbon scaffold, and their pu-tative biosynthetic pathways were discussed; artemdubinoid C (3) was a novel guaianolide derivative that might be formed by the [4 + 2] Diels-Alder reaction; artemdubinoids D and E (4-5) were rare 1,10-seco-guaianolides; artemdubinoids F-K (6-11) were chlorine -containing guaianolides. Eleven compounds exhibited cytotoxicity against three human hepatoma cell lines (HepG2, Huh7, and SK-Hep-1) with half-maximal inhibitory concentration (IC50) values spanning 7.5-82.5 mu mol center dot L-1. Artemdubinoid M (13) exhibited the most active cytotoxicity with IC50 values of 14.5, 7.5 and 8.9 mu mol center dot L-1 against the HepG2, Huh7, and SK-Hep-1 cell lines, respectively, which were equivalent to the positive control, sorafenib.
Keyword	Artemdubinoids A-N Artemisia dubia Sesquiterpenoids Antihepatoma activity
DOI	10.1016/S1875-5364(23)60441-8
Indexed By	SCI
WOS ID	WOS:001146225500001
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/75450
Collection	中国科学院昆明植物研究所
Recommended Citation GB/T 7714	Gao,Zhen,Li,Tianze,Ma,Yunbao,et al. Artemdubinoids A-N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2023,21(12):902-915.
APA	Gao,Zhen.,Li,Tianze.,Ma,Yunbao.,Huang,Xiaoyan.,Geng,Changan.,...&Chen,Jijun.(2023).Artemdubinoids A-N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia.CHINESE JOURNAL OF NATURAL MEDICINES,21(12),902-915.
MLA	Gao,Zhen,et al."Artemdubinoids A-N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia".CHINESE JOURNAL OF NATURAL MEDICINES 21.12(2023):902-915.

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