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UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations Eph antagonist and angiogenesis 期刊论文
出版物, 3111, 期号: 0, 页码: 1-32
Authors:  I Hassan-Mohamed;  C Giorgio;  M Incerti;  S Russo;  D Pala;  E B Pasquale;  P Vicini;  E Barocelli;  S Rivara;  M Mor;  A Lodola;  M Tognolini
Adobe PDF(1403Kb)  |  Favorite  |  View/Download:112/1  |  Submit date:2017/07/24
Eph Kinase  Ephrin  Small Molecules  Angiogenesis  Bile Acid  Lithocholic Acid  
Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2162-2178
Authors:  Zhao, Qi;  Zhang, Ting;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Wang, Yan;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(3915Kb)  |  Favorite  |  View/Download:34/0  |  Submit date:2019/07/29
A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice 期刊论文
XENOBIOTICA, 2019, 卷号: 49, 期号: 6, 页码: 655-670
Authors:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Liang, Wei-Qing;  Xiao, Yao;  Zhao, Qi;  Xiao, Xue-Rong;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(1101Kb)  |  Favorite  |  View/Download:31/0  |  Submit date:2019/07/29
Pazopanib  hepatotoxicity  metabolomics  oxidative stress  ultra-performance liquid chromatography-electrospray ion source-quadrupole  time-of-flight mass spectrometer (UPLC-ESI-QTOFMS)  
Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling 期刊论文
MOLECULAR & CELLULAR PROTEOMICS, 2019, 卷号: 18, 期号: 3, 页码: 520-533
Authors:  Zhao, Qi;  Liu, Fang;  Cheng, Yan;  Xiao, Xue-Rong;  Hu, Dan-Dan;  Tang, Ying-Mei;  Bao, Wei-Min;  Yang, Jin-Hui;  Jiang, Tao;  Hu, Jia-Peng;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(4782Kb)  |  Favorite  |  View/Download:16/0  |  Submit date:2019/07/29
Modulation of Lipid Metabolism by Celastrol 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2019, 卷号: 18, 期号: 3, 页码: 1133-1144
Authors:  Zhang, Ting;  Zhao, Qi;  Xiao, Xuerong;  Yang, Rui;  Hu, Dandan;  Zhu, Xu;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(5774Kb)  |  Favorite  |  View/Download:109/0  |  Submit date:2019/04/15
celastrol  lipidomics  hyperlipidemia  LC-MS  
Basal PPAR alpha inhibits bile acid metabolism adaptation in chronic cholestatic model induced by alpha-naphthylisothiocyanate 期刊论文
TOXICOLOGY LETTERS, 2019, 卷号: 300, 页码: 31-39
Authors:  Hua, Huiying;  Dai, Manyun;  Luo, Yishuang;  Lin, Hante;  Xu, Gangming;  Hu, Xiaowei;  Xu, Liping;  Zhang, Haoyue;  Tang, Zhiyuan;  Chang, Liming;  Liu, Aiming;  Yang, Julin
View  |  Adobe PDF(3156Kb)  |  Favorite  |  View/Download:176/0  |  Submit date:2018/12/18
PPAR alpha  FXR pathway  Alpha-naphthylisothiocyanate  Chronic cholestasis  
Metabolomic analysis of cholestatic liver damage in mice 期刊论文
FOOD AND CHEMICAL TOXICOLOGY, 2018, 卷号: 120, 页码: 253-260
Authors:  Yang, Rui;  Zhao, Qi;  Hu, Dan-Dan;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Li, Fei
Favorite  |  View/Download:35/0  |  Submit date:2018/11/12
Cholestatic liver damage  PBC  PSC  Metabolomics  QTOFMS  
PPAR alpha Mediates the Hepatoprotective Effects of Nutmeg 期刊论文
JOURNAL OF PROTEOME RESEARCH, 2018, 卷号: 17, 期号: 5, 页码: 1887-1897
Authors:  Yang, Xiao-Nan;  Liu, Xue-Mei;  Fang, Jian-He;  Zhu, Xu;  Yang, Xiu-Wei;  Xiao, Xue-Rong;  Huang, Jian-Feng;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(2643Kb)  |  Favorite  |  View/Download:105/16  |  Submit date:2018/07/02
Nutmeg  Hepatoprotective Activity  Metabolomics  Myrislignan  Ppar Alpha  
PPAR alpha activation protects against cholestatic liver injury 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 页码: 9967
Authors:  Zhao, Qi;  Yang, Rui;  Wang, Jing;  Hu, Dan-Dan;  Li, Fei
View  |  Adobe PDF(7693Kb)  |  Favorite  |  View/Download:101/11  |  Submit date:2017/10/23
Primary Biliary-cirrhosis  Bile-acid Homeostasis  Receptor-alpha  Ursodeoxycholic Acid  Cholesterol 7-alpha-hydroxylase  Beta-oxidation  Fenofibrate  Therapy  Mice  Hepatotoxicity  
Metabolomics reveals that PPAR alpha activation protects against lithocholic acid-induced liver injury 期刊论文
RSC ADVANCES, 2017, 卷号: 7, 期号: 79, 页码: 49849-49857
Authors:  Zhao, Qi;  Yang, Rui;  Liu, Fang;  Wang, Jing;  Hu, Dan-Dan;  Yang, Xiu-Wei;  Li, Fei
View  |  Adobe PDF(1264Kb)  |  Favorite  |  View/Download:85/6  |  Submit date:2017/12/18