Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling
Zhao, Qi1,2; Liu, Fang1; Cheng, Yan1; Xiao, Xue-Rong1; Hu, Dan-Dan1; Tang, Ying-Mei3; Bao, Wei-Min4; Yang, Jin-Hui3; Jiang, Tao3; Hu, Jia-Peng5; Gonzalez, Frank J.6; Li, Fei1,7
Corresponding AuthorTang, Ying-Mei(tangyingmei_med@163.com) ; Li, Fei(lifeib@mail.kib.ac.cn)
2019-03-01
Source PublicationMOLECULAR & CELLULAR PROTEOMICS
ISSN1535-9476
Volume18Issue:3Pages:520-533
AbstractCelastrol, derived from the roots of the Tripterygium Wilfordi, shows a striking effect on obesity. In the present study, the role of celastrol in cholestasis was investigated using metabolomics and transcriptomics. Celastrol treatment significantly alleviated cholestatic liver injury in mice induced by alpha-naphthyl isothiocyanate (ANIT) and thioacetamide (TAA). Celastrol was found to activate sirtuin 1 (SIRT1), increase farnesoid X receptor (FXR) signaling and inhibit nuclear factor-kappa B and P53 signaling. The protective role of celastrol in cholestatic liver injury was diminished in mice on co-administration of SIRT1 inhibitors. Further, the effects of celastrol on cholestatic liver injury were dramatically decreased in Fxr-null mice, suggesting that the SIRT1-FXR signaling pathway mediates the protective effects of celastrol. These observations demonstrated a novel role for celastrol in protecting against cholestatic liver injury through modulation of the SIRT1 and FXR.
DOI10.1074/mcp.RA118.000817
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemical Research Methods
WOS IDWOS:000467885100010
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67578
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorTang, Ying-Mei; Li, Fei
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Kunming Med Univ, Affiliated Hosp 2, Yunnan Res Ctr Liver Dis, Dept Gastroenterol, Kunming 650033, Yunnan, Peoples R China
4.Yunnan Prov 1st Peoples Hosp, Dept Gen Surg, Kunming 650032, Yunnan, Peoples R China
5.Kunming Med Univ, Affiliated Hosp 2, Clin Lab, Kunming 650033, Yunnan, Peoples R China
6.NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
7.Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Qi,Liu, Fang,Cheng, Yan,et al. Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling[J]. MOLECULAR & CELLULAR PROTEOMICS,2019,18(3):520-533.
APA Zhao, Qi.,Liu, Fang.,Cheng, Yan.,Xiao, Xue-Rong.,Hu, Dan-Dan.,...&Li, Fei.(2019).Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling.MOLECULAR & CELLULAR PROTEOMICS,18(3),520-533.
MLA Zhao, Qi,et al."Celastrol Protects From Cholestatic Liver Injury Through Modulation of SIRT1-FXR Signaling".MOLECULAR & CELLULAR PROTEOMICS 18.3(2019):520-533.
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