Basal PPAR alpha inhibits bile acid metabolism adaptation in chronic cholestatic model induced by alpha-naphthylisothiocyanate
Hua, Huiying1; Dai, Manyun1,2,3; Luo, Yishuang1; Lin, Hante1; Xu, Gangming1; Hu, Xiaowei1; Xu, Liping1; Zhang, Haoyue1; Tang, Zhiyuan1; Chang, Liming1; Liu, Aiming1; Yang, Julin4
2019
Source PublicationTOXICOLOGY LETTERS
ISSN0378-4274
Volume300Pages:31-39
AbstractCholestasis is one of the most challenging diseases to be treated in current hepatology. However little is known about the adaptation difference and the underlying mechanism between acute and chronic cholestasis. In this study, wild-type and Ppar alpha-null mice were orally administered diet containing 0.05% ANIT to induce chronic cholestasis. Biochemistry, histopathology and serum metabolome analysis exhibited the similar toxic phenotype between wild-type and Ppar alpha-null mice. Bile acid metabolism was strongly adapted in Ppar alpha-null mice but not in wild-type mice. The Shp and Fxr mRNA was found to be doubled in cholestatic Ppar alpha-null mice compared with the control group. Western blot confirmed the up-regulated expression of FXR in Ppar alpha-null mice treated with ANIT. Inflammation was found to be stronger in Ppar alpha-null mice than those in wild-type mice in chronic cholestasis. These data chain indicated that bile acid metabolism and inflammation signaling were different between wild-type and Ppar alpha-null mice developing chronic cholestasis, although their toxic phenotypes could not be discriminated. So basal Ppar alpha cross-talked with FXR and inhibited bile acid metabolism adaptation in chronic cholestasis.
KeywordPPAR alpha FXR pathway Alpha-naphthylisothiocyanate Chronic cholestasis
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/63162
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLiu, Aiming; Yang, Julin
Affiliation1.Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Ningbo Coll Hlth Sci, Ningbo 315100, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Hua, Huiying,Dai, Manyun,Luo, Yishuang,et al. Basal PPAR alpha inhibits bile acid metabolism adaptation in chronic cholestatic model induced by alpha-naphthylisothiocyanate[J]. TOXICOLOGY LETTERS,2019,300:31-39.
APA Hua, Huiying.,Dai, Manyun.,Luo, Yishuang.,Lin, Hante.,Xu, Gangming.,...&Yang, Julin.(2019).Basal PPAR alpha inhibits bile acid metabolism adaptation in chronic cholestatic model induced by alpha-naphthylisothiocyanate.TOXICOLOGY LETTERS,300,31-39.
MLA Hua, Huiying,et al."Basal PPAR alpha inhibits bile acid metabolism adaptation in chronic cholestatic model induced by alpha-naphthylisothiocyanate".TOXICOLOGY LETTERS 300(2019):31-39.
Files in This Item: Download All
File Name/Size DocType Version Access License
Hua-2019-Basal PPAR (3156KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hua, Huiying]'s Articles
[Dai, Manyun]'s Articles
[Luo, Yishuang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hua, Huiying]'s Articles
[Dai, Manyun]'s Articles
[Luo, Yishuang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hua, Huiying]'s Articles
[Dai, Manyun]'s Articles
[Luo, Yishuang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Hua-2019-Basal PPAR alpha inhibits bile acid m.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.