Metabolomics Reveals Gut Microbiota Contribute to PPARα Deficiency-Induced Alcoholic Liver Injury

doi:10.1021/acs.jproteome.3c00093

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	Metabolomics Reveals Gut Microbiota Contribute to PPARα Deficiency-Induced Alcoholic Liver Injury
	Zhang,Ting; Bao,Lijuan; Zhao,Qi; Wu,Zhanxuan E. E.; Dai,Manyun; Rao,Qianru; Li,Fei
	2023
发表期刊	JOURNAL OF PROTEOME RESEARCH
ISSN	1535-3907
卷号	22 期号:7 页码:2327-2338
摘要	Incidence and mortality rates of alcoholic liver disease (ALD) is one of the highest in the world. In the present study, we found that the genetic knockout nuclear receptor the peroxisome proliferator-activated receptor a (PPARa) exacerbated ALD. Lipidomics of the liver revealed changed levels of lipid species encompassing phospholipids, ceramides (CM), and long-chain fatty acids in Ppara-null mice induced by ethanol. Moreover, 4-hydroxyphenylacetic acid (4-HPA) was changed as induced by ethanol in the metabolome of urine. Moreover, the phylum level analysis showed a decrease in the level of Bacteroidetes and an increase in the level of Firmicutes after alcohol feeding in Ppara-null mice, while there was no change in wild-type mice. In Ppara-null mice, the level of Clostridium_sensu_stricto_1 and Romboutsia were upregulated after alcohol feeding. These data revealed that PPARa deficiency potentiated alcohol-induced liver injury through promotion of lipid accumulation, changing the metabolome of urine, and increasing the level of Clostridium_sensu_stricto_1 and Romboutsia. 4-HPA could improve ALD in mice by regulating inflammation and lipid metabolism. Therefore, our findings suggest a novel approach to the treatment of ALD: focusing on the gut microbiota and its metabolites. Data are available via ProteomeXchange (PXD 041465).
关键词	metabolomics alcohol-induced liver injury gut microbiota PPAR & alpha AROMATIC-AMINO-ACIDS LIPID-METABOLISM FED MICE MODULATION DISEASE AXIS OLEOYLETHANOLAMIDE AGONIST OBESITY DEATH
DOI	10.1021/acs.jproteome.3c00093
收录类别	SCI
WOS记录号	WOS:001015268200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75290
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhang,Ting,Bao,Lijuan,Zhao,Qi,et al. Metabolomics Reveals Gut Microbiota Contribute to PPARα Deficiency-Induced Alcoholic Liver Injury[J]. JOURNAL OF PROTEOME RESEARCH,2023,22(7):2327-2338.
APA	Zhang,Ting.,Bao,Lijuan.,Zhao,Qi.,Wu,Zhanxuan E. E..,Dai,Manyun.,...&Li,Fei.(2023).Metabolomics Reveals Gut Microbiota Contribute to PPARα Deficiency-Induced Alcoholic Liver Injury.JOURNAL OF PROTEOME RESEARCH,22(7),2327-2338.
MLA	Zhang,Ting,et al."Metabolomics Reveals Gut Microbiota Contribute to PPARα Deficiency-Induced Alcoholic Liver Injury".JOURNAL OF PROTEOME RESEARCH 22.7(2023):2327-2338.

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