Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense | |
Chen, Xuan-Qin1; Shao, Li-Dong1; Pal, Mahesh2; Shen, Yu3; Cheng, Xiao1; Xu, Gang1; Peng, Li-Yan1; Wang, Kou1; Pan, Zheng-Hong1; Li, Ming-Ming1; Leng, Ying3; He, Juan1; Zhao, Qin-Shi1; He,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Yunnan,Peoples R China.; hejuan@mail.kib.ac.cn; qinshizhao@mail.kib.ac.cn | |
2015-02-01 | |
发表期刊 | JOURNAL OF NATURAL PRODUCTS |
卷号 | 78期号:2页码:330-334 |
摘要 | Five selective 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) competitive inhibitors, hupehenols AE (1-5), were isolated from Viburnum hupehense. The structure elucidation indicated that compounds 1-5 are new 20,21,22,23,24,25,26,27-octanordammarane triterpenoids. Their structures were established on the basis of NMR spectroscopic and mass spectrometric analysis. Hupehenols AE (1-5) showed inhibition against human 11 beta-HSD1, with hupehenols B (2) and E (5) having IC50 values of 15.3 and 34.0 nM, respectively. Moreover, hupehenols C (3) and D (4) are highly selective inhibitors of human 11 beta-HSD1 when compared to murine 11 beta-HSD1.T |
学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
DOI | 10.1021/np500896n |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000350328600024 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/20579 |
专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
通讯作者 | He,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Yunnan,Peoples R China.; hejuan@mail.kib.ac.cn; qinshizhao@mail.kib.ac.cn |
作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China 2.CSIR Natl Bot Res Inst, Phytochem Div, Lucknow 226001, Uttar Pradesh, India 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Xuan-Qin,Shao, Li-Dong,Pal, Mahesh,et al. Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(2):330-334. |
APA | Chen, Xuan-Qin.,Shao, Li-Dong.,Pal, Mahesh.,Shen, Yu.,Cheng, Xiao.,...&qinshizhao@mail.kib.ac.cn.(2015).Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense.JOURNAL OF NATURAL PRODUCTS,78(2),330-334. |
MLA | Chen, Xuan-Qin,et al."Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense".JOURNAL OF NATURAL PRODUCTS 78.2(2015):330-334. |
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