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题名: Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense
作者: Chen, Xuan-Qin1; Shao, Li-Dong1; Pal, Mahesh2; Shen, Yu3; Cheng, Xiao1; null(许刚)1; Peng, Li-Yan1; Wang, Kou1; Pan, Zheng-Hong1; Li, Ming-Ming1; Leng, Ying3; He, Juan1; null(赵勤实)1
刊名: JOURNAL OF NATURAL PRODUCTS
英文摘要: Five selective 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) competitive inhibitors, hupehenols AE (1-5), were isolated from Viburnum hupehense. The structure elucidation indicated that compounds 1-5 are new 20,21,22,23,24,25,26,27-octanordammarane triterpenoids. Their structures were established on the basis of NMR spectroscopic and mass spectrometric analysis. Hupehenols AE (1-5) showed inhibition against human 11 beta-HSD1, with hupehenols B (2) and E (5) having IC50 values of 15.3 and 34.0 nM, respectively. Moreover, hupehenols C (3) and D (4) are highly selective inhibitors of human 11 beta-HSD1 when compared to murine 11 beta-HSD1.T
出版日期: 2015-02-01
卷号: 78, 期号:2, 页码:330-334
DOI标识: 10.1021/np500896n
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20579
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
2.CSIR Natl Bot Res Inst, Phytochem Div, Lucknow 226001, Uttar Pradesh, India
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
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