Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense
Chen, Xuan-Qin1; Shao, Li-Dong1; Pal, Mahesh2; Shen, Yu3; Cheng, Xiao1; Xu, Gang1; Peng, Li-Yan1; Wang, Kou1; Pan, Zheng-Hong1; Li, Ming-Ming1; Leng, Ying3; He, Juan1; Zhao, Qin-Shi1; He,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Yunnan,Peoples R China.; hejuan@mail.kib.ac.cn; qinshizhao@mail.kib.ac.cn
2015-02-01
发表期刊JOURNAL OF NATURAL PRODUCTS
卷号78期号:2页码:330-334
摘要Five selective 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) competitive inhibitors, hupehenols AE (1-5), were isolated from Viburnum hupehense. The structure elucidation indicated that compounds 1-5 are new 20,21,22,23,24,25,26,27-octanordammarane triterpenoids. Their structures were established on the basis of NMR spectroscopic and mass spectrometric analysis. Hupehenols AE (1-5) showed inhibition against human 11 beta-HSD1, with hupehenols B (2) and E (5) having IC50 values of 15.3 and 34.0 nM, respectively. Moreover, hupehenols C (3) and D (4) are highly selective inhibitors of human 11 beta-HSD1 when compared to murine 11 beta-HSD1.T
资助信息National Natural Science Foundation of China [81102347]; National Basic Research Program of China (973 Program) [2011CB915503]
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np500896n
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000350328600024
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20579
专题植物化学与西部植物资源持续利用国家重点实验室
通讯作者He,J (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650204,Yunnan,Peoples R China.; hejuan@mail.kib.ac.cn; qinshizhao@mail.kib.ac.cn
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Yunnan, Peoples R China
2.CSIR Natl Bot Res Inst, Phytochem Div, Lucknow 226001, Uttar Pradesh, India
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
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Chen, Xuan-Qin,Shao, Li-Dong,Pal, Mahesh,et al. Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(2):330-334.
APA Chen, Xuan-Qin.,Shao, Li-Dong.,Pal, Mahesh.,Shen, Yu.,Cheng, Xiao.,...&qinshizhao@mail.kib.ac.cn.(2015).Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense.JOURNAL OF NATURAL PRODUCTS,78(2),330-334.
MLA Chen, Xuan-Qin,et al."Hupehenols A-E, Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 (11 beta-HSD1) Inhibitors from Viburnum hupehense".JOURNAL OF NATURAL PRODUCTS 78.2(2015):330-334.
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