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题名: 16-nor Limonoids from Harrisonia perforata as promising selective 11 beta-HSD1 inhibitors
作者: Xiao-HuiYan1, 2; Yi, Ping3, 4; Cao, Pei1; Yang, Shi-Ying5, 6; Fang, Xin1; Zhang, Yu1; Wu, Bin1; Leng, Ying7; Di, Ying-Tong1; Lv, Yang5, 6; null(郝小江)1
刊名: SCIENTIFIC REPORTS
英文摘要: Two new 16-nor limonoids, harperspinoids A and B (1 and 2), with a unique 7/5/5/6/5 ring system, have been isolated from the plant Harrisonia perforate together with a known one, Harperforin G (3). Their structures were elucidated by NMR spectroscopy, X-ray diffraction analysis and computational modelling. Compound 1 exists as polymorphic crystals. Conformations of 1 in solution were further discussed based on the computational results. These compounds exhibited notable inhibitory activity against the 11 beta-HSD1 enzyme. Compound 3 had potencies for the inhibition of human 11 beta-HSD1 with high selectivity against 11 beta-HSD2 (IC50 0.58 mu M, SI > 174). Molecular docking and quantitative structure-activity relationship studies revealed a mixed regulatory mechanism.
出版日期: 2016-11-11
卷号: 6, 页码:1
DOI标识: 10.1038/srep36927
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/33667
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Southwest Forestry Univ, Coll Forestry, Key Lab Forest Disaster Warning & Control Yunnan, Kunming 650224, Peoples R China
3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
4.Chinese Acad Sci, Guiyang 550002, Peoples R China
5.Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Polymorph Drugs, Beijing 100050, Peoples R China
6.Peking Union Med Coll, Beijing 100050, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China

Recommended Citation:
Xiao-HuiYan,Yi, Ping,Cao, Pei,et al. 16-nor Limonoids from Harrisonia perforata as promising selective 11 beta-HSD1 inhibitors[J]. SCIENTIFIC REPORTS,2016,6:1.
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