KIB OpenIR
Discovery of novel coffee diterpenoids with inhibitions on Ca(v)3.1 low voltage-gated Ca2+ channel
Hu,Guilin; Dong,Ding; Du,Shuzong; Peng,Xingrong; Wu,Mingkun; Shi,Qiangqiang; Hu,Kun; Hong,Defu; Wang,Xiaoyuan; Zhou,Lin; Nian,Yin; Qiu,Minghua
2022
Source PublicationFOOD CHEMISTRY
ISSN0308-8146
Volume376Pages:131923
AbstractSeven new (1-4, 6-8) diterpenoids with rare skeletons and seven known ones (9, 12, 17, 18 and 23-25) were isolated from roasted beans of Coffea arabica L. Together with previously obtained diterpenoids, a total of 26 molecules (1-25, 4a) were evaluated their activities on Ca(v)3.1 low voltage-gated Ca2+ channel. Compounds 1, 3, 6, 7, 12, 13, 17, 19 and 24 exhibited noticeable Ca(v)3.1 inhibitions (41.2%-96.1%) at 10 mu M. The IC50 values of 1, 6, 7, 12, 13, 17 and 24 are 2.9, 2.3, 0.68, 14.8, 11.6, 6.1 and 6.8 mu M, respectively. The ring moiety at C-18 and C-19, and esterification of OH-17 with long-chain fatty acids seem important for their activities. Further studies indicated that 1 and cafestol may act on different binding sits with the Ca(v)3.1 blocker Z944, which is in clinical trial. Significantly, the present study initially shows that coffee diterpenoids are potential natural resources for Ca(v)3.1 inhibitors.
KeywordCoffea arabica L Roasted coffee Coffee diterpenoid Cafestol Kahweol T-type Ca2+ channels Ca(v)3.1 low voltage-gated Ca2+ channel Ca(v)3.1 inhibitors CALCIUM-CHANNELS CAFESTOL KAHWEOL PHYSIOLOGY ESTERS NOMENCLATURE PHARMACOLOGY APOPTOSIS FURANS
DOI10.1016/j.foodchem.2021.131923
WOS IDWOS:000741200300008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73390
Collection中国科学院昆明植物研究所
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
4.Chinese Acad Sci, Kunming Inst Zool, Ion Channel Res & Drug Dev Ctr, Kunming 650223, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Hu,Guilin,Dong,Ding,Du,Shuzong,et al. Discovery of novel coffee diterpenoids with inhibitions on Ca(v)3.1 low voltage-gated Ca2+ channel[J]. FOOD CHEMISTRY,2022,376:131923.
APA Hu,Guilin.,Dong,Ding.,Du,Shuzong.,Peng,Xingrong.,Wu,Mingkun.,...&Qiu,Minghua.(2022).Discovery of novel coffee diterpenoids with inhibitions on Ca(v)3.1 low voltage-gated Ca2+ channel.FOOD CHEMISTRY,376,131923.
MLA Hu,Guilin,et al."Discovery of novel coffee diterpenoids with inhibitions on Ca(v)3.1 low voltage-gated Ca2+ channel".FOOD CHEMISTRY 376(2022):131923.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hu,Guilin]'s Articles
[Dong,Ding]'s Articles
[Du,Shuzong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hu,Guilin]'s Articles
[Dong,Ding]'s Articles
[Du,Shuzong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hu,Guilin]'s Articles
[Dong,Ding]'s Articles
[Du,Shuzong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.