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Neothalfine, a potent natural anti-tumor agent against metastatic colorectal cancer and its primary mechanism 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 115849
Authors:  Zhu,Yan-Yan;  Jin,Qiong;  Chen,Shan-Shan;  Jin,Dan-Ni;  Wang,Zhao-Jie;  He,Ying-Jie;  Chen,Hui-Cheng;  Zhao,Yun-Li;  Zhao,Li-Xing;  Dai,Zhi;  Luo,Xiao-Dong
Favorite  |  View/Download:18/0  |  Submit date:2022/04/02
Neothalfine  Bisbenzylisoquinoline alkaloid  Metastatic colorectal cancer  Metabolomic  Mitochondrial apoptosis  SMALL MOLECULES  IRINOTECAN  RESISTANCE  CELL  IMMUNOTHERAPY  OPPORTUNITIES  CHEMOTHERAPY  VINORELBINE  ALKALOIDS  PATHWAY  
Synthesis and antitumor activity of camptothecin-4 beta-triazolopodophyllotoxin conjugates 期刊论文
NATURAL PRODUCT RESEARCH, 2020
Authors:  Zi, Cheng-Ting;  Yang, Liu;  Dong, Fa-Wu;  Kong, Qing-Hua;  Ding, Zhong-Tao;  Zhou, Jun;  Jiang, Zi-Hua;  Hu, Jiang-Miao
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The amazing potential of fungi: 50 ways we can exploit fungi industrially 期刊论文
FUNGAL DIVERSITY, 2019, 卷号: 97, 期号: 1, 页码: 1-136
Authors:  Hyde, Kevin D.;  Xu, Jianchu;  Rapior, Sylvie;  Jeewon, Rajesh;  Lumyong, Saisamorn;  Niego, Allen Grace T.;  Abeywickrama, Pranami D.;  Aluthmuhandiram, Janith V. S.;  Brahamanage, Rashika S.;  Brooks, Siraprapa;  Chaiyasen, Amornrat;  Chethana, K. W. Thilini;  Chomnunti, Putarak;  Chepkirui, Clara;  Chuankid, Boontiya;  de Silva, Nimali I.;  Doilom, Mingkwan;  Faulds, Craig;  Gentekaki, Eleni;  Gopalan, Venkat;  Kakumyan, Pattana;  Harishchandra, Dulanjalee;  Hemachandran, Hridya;  Hongsanan, Sinang;  Karunarathna, Anuruddha;  Karunarathna, Samantha C.;  Khan, Sehroon;  Kumla, Jaturong;  Jayawardena, Ruvishika S.;  Liu, Jian-Kui;  Liu, Ningguo;  Luangharn, Thatsanee;  Macabeo, Allan Patrick G.;  Marasinghe, Diana S.;  Meeks, Dan;  Mortimer, Peter E.;  Mueller, Peter;  Nadir, Sadia;  Nataraja, Karaba N.;  Nontachaiyapoom, Sureeporn;  O'Brien, Meghan;  Penkhrue, Watsana;  Phukhamsakda, Chayanard;  Ramanan, Uma Shaanker;  Rathnayaka, Achala R.;  Sadaba, Resurreccion B.;  Sandargo, Birthe;  Samarakoon, Binu C.;  Tennakoon, Danushka S.;  Siva, Ramamoorthy;  Sriprom, Wasan;  Suryanarayanan, T. S.;  Sujarit, Kanaporn;  Suwannarach, Nakarin;  Suwunwong, Thitipone;  Thongbai, Benjarong;  Thongklang, Naritsada;  Wei, Deping;  Wijesinghe, S. Nuwanthika;  Winiski, Jake;  Yan, Jiye;  Yasanthika, Erandi;  Stadler, Marc
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Biocontrol  Biodiversity  Biotechnology  Food  Fungi  Mushrooms  
A metabolomic perspective of pazopanib-induced acute hepatotoxicity in mice 期刊论文
XENOBIOTICA, 2019, 卷号: 49, 期号: 6, 页码: 655-670
Authors:  Wang, Yi-Kun;  Yang, Xiao-Nan;  Liang, Wei-Qing;  Xiao, Yao;  Zhao, Qi;  Xiao, Xue-Rong;  Gonzalez, Frank J.;  Li, Fei
View  |  Adobe PDF(1101Kb)  |  Favorite  |  View/Download:85/11  |  Submit date:2019/07/29
Pazopanib  hepatotoxicity  metabolomics  oxidative stress  ultra-performance liquid chromatography-electrospray ion source-quadrupole  time-of-flight mass spectrometer (UPLC-ESI-QTOFMS)  
RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 9, 页码: 14
Authors:  Guo, Di;  Wang, Yurong;  Wang, Jing;  Song, Lihua;  Wang, Zhe;  Mao, Bingyu;  Tan, Ninghua
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RA-XII  lipogenesis  SCAP  SREBP  liver cancer  
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
Authors:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan;  Zhang, Zhi-Rong;  Li, Ning;  Li, Ren-Da;  Wan, Jun;  Sun, Han-Dong;  Sun, Nan;  Puno, Pema-Tenzin;  He, Jie
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Acetyl-macrocalin B  Reactive oxygen species  p38 MAPK  Chk1/Chk2  Esophageal squamous cell carcinoma  
Synthesis and antitumor activity of biotinylated camptothecin derivatives as potent cytotoxic agents 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 2, 页码: 234-237
Authors:  Zi, Cheng-Ting;  Yang, Liu;  Xu, Feng-Qing;  Dong, Fa-Wu;  Ma, Rui-Jing;  Li, Yan;  Zhou, Jun;  Ding, Zhong-Tao;  Jiang, Zi-Hua;  Hu, Jiang-Miao
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Biodnylated Camptothecin Derivatives  Anticancer Activity  Synthesis  Click Chemistry  Structure-activity Relationships (Sars)  
Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 150, 页码: 189-199
Authors:  Li, Mingyue;  Yue, Grace Gar-Lee;  Song, Li-Hua;  Huang, Mao-Bo;  Lee, Julia Kin-Ming;  Tsui, Stephen Kwok-Wing;  Fung, Kwok-Pui;  Tan, Ning-Hua;  Lau, Clara Bik-San
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Bigelovin  Colorectal Cancer  Metastasis  Tumor Microenvironment  Ll6/stat3 Pathway  
Meroterpenoids with Antitumor Activities from Guava (Psidium guajava) 期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017, 卷号: 65, 期号: 24, 页码: 4993-4999
Authors:  Qin, Xu-Jie;  Yu, Qian;  Yan, Huan;  Khan, Afsar;  Feng, Mi-Yan;  Li, Pan-Pan;  Hao, Xiao-Jiang;  An, Lin-Kun;  Liu, Hai-Yang
Adobe PDF(3439Kb)  |  Favorite  |  View/Download:201/51  |  Submit date:2017/07/31
Guava  Meroterpenoids  Cytotoxicity  Dna Topoisomerase i Inhibitors  Antiproliferative Activity  
三种天然产物的结构修饰与生物活性研究 学位论文
: 中国科学院大学, 2017
Authors:  任健
Adobe PDF(19285Kb)  |  Favorite  |  View/Download:53/11  |  Submit date:2019/06/14