Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway
Li, Mingyue1,2; Yue, Grace Gar-Lee2,3; Song, Li-Hua4; Huang, Mao-Bo5; Lee, Julia Kin-Ming2,3; Tsui, Stephen Kwok-Wing1; Fung, Kwok-Pui1,2,3; Tan, Ning-Hua4,5; Lau, Clara Bik-San2,3
2018-04-01
Source PublicationBIOCHEMICAL PHARMACOLOGY
ISSN0006-2952
Volume150Pages:189-199
AbstractBigelovin, a sesquiterpene lactone, has been demonstrated to induce apoptosis, inhibit inflammation and angiogenesis in vitro, but its potential anti-metastatic activity remains unclear. In the present study, two colon cancer mouse models, orthotopic tumor allografts and experimental metastatic models were utilized to investigate the progression and metastatic spread of colorectal cancer after bigelovin treatments. Results showed that bigelovin (intravenous injection; 0.3-3 mg/kg) significantly suppressed tumor growth and inhibited liver/ lung metastasis with modulation of tumor microenvironment (e.g. increased populations of T lymphocytes and macrophages) in orthotopic colon tumor allograft-bearing mice. Furthermore, the inhibitory activities were also validated in the experimental human colon cancer metastatic mouse model. The underlying mechanisms involved in the anti-metastatic effects of bigelovin were then revealed in murine colon tumor cells colon 26-M01 and human colon cancer cells HCT116. Results showed that bigelovin induced cytotoxicity, inhibition of cell proliferation, motility and migration in both cell lines, which were through interfering II.6/STAT3 and cofilin pathways. Alternations of the key molecules including Rock, FAK, RhoA, Rac1/2/3 and N-cadherin, which were detected in bigelovin-treated cancer cells, were also observed in the tumor allografts of bigelovin-treated mice. These findings strongly indicated that bigelovin has potential to be developed as anti-tumor and anti-metastatic agent for colorectal cancer.
KeywordBigelovin Colorectal Cancer Metastasis Tumor Microenvironment Ll6/stat3 Pathway
DOI10.1016/j.bcp.2018.02.017
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/61251
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
2.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
3.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China
4.China Pharmaceut Univ, Sch Tradit Chinese Pharm, 639 Longmian Ave, Nanjing 211198, Jiangsu, Peoples R China
5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, Mingyue,Yue, Grace Gar-Lee,Song, Li-Hua,et al. Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway[J]. BIOCHEMICAL PHARMACOLOGY,2018,150:189-199.
APA Li, Mingyue.,Yue, Grace Gar-Lee.,Song, Li-Hua.,Huang, Mao-Bo.,Lee, Julia Kin-Ming.,...&Lau, Clara Bik-San.(2018).Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway.BIOCHEMICAL PHARMACOLOGY,150,189-199.
MLA Li, Mingyue,et al."Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway".BIOCHEMICAL PHARMACOLOGY 150(2018):189-199.
Files in This Item: Download All
File Name/Size DocType Version Access License
li2018.pdf(2333KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Mingyue]'s Articles
[Yue, Grace Gar-Lee]'s Articles
[Song, Li-Hua]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Mingyue]'s Articles
[Yue, Grace Gar-Lee]'s Articles
[Song, Li-Hua]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Mingyue]'s Articles
[Yue, Grace Gar-Lee]'s Articles
[Song, Li-Hua]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: li2018.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.