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Neothalfine, a potent natural anti-tumor agent against metastatic colorectal cancer and its primary mechanism 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 115849
Authors:  Zhu,Yan-Yan;  Jin,Qiong;  Chen,Shan-Shan;  Jin,Dan-Ni;  Wang,Zhao-Jie;  He,Ying-Jie;  Chen,Hui-Cheng;  Zhao,Yun-Li;  Zhao,Li-Xing;  Dai,Zhi;  Luo,Xiao-Dong
Favorite  |  View/Download:10/0  |  Submit date:2022/04/02
Neothalfine  Bisbenzylisoquinoline alkaloid  Metastatic colorectal cancer  Metabolomic  Mitochondrial apoptosis  SMALL MOLECULES  IRINOTECAN  RESISTANCE  CELL  IMMUNOTHERAPY  OPPORTUNITIES  CHEMOTHERAPY  VINORELBINE  ALKALOIDS  PATHWAY  
Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus 期刊论文
MOLECULES, 2021, 卷号: 26, 期号: 21, 页码: 6516
Authors:  Deng,Zhen-Tao;  Li,Wen-Yan;  Wang,Lei;  Zhou,Zhi-Ping;  Wu,Xing-De;  Ding,Zhong-Tao;  Zhao,Qin-Shi
Favorite  |  View/Download:5/0  |  Submit date:2022/04/02
Catharanthus roseus  monoterpene indole alkaloid  catharanosine A  Ca(v)3  1 low voltage-gated calcium channel (LVGCC)  VINCA ALKALOIDS  CELL-PROLIFERATION  N-OXIDE  SARPAGINE  BIOSYNTHESIS  VINORELBINE  VINBLASTINE  MECHANISM  ROOTS  BASES  
Trimeric and dimeric Aspidosperma-type alkaloids from leaves of Tabernaemontana divaricata 'Dwaft' 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105314
Authors:  Chen,Jing;  Yu,Yang;  Wu,Jing;  Bao,Mei-Fen;  Kongkiatpaiboon,Sumet;  Schinnerl,Johann;  Cai,Xiang-Hai
Favorite  |  View/Download:3/0  |  Submit date:2022/04/02
Tabernaemontana divaricata 'Dwaft'  Monoterpenoid indole alkaloid  Aspidosperma-type trimmers  Aspidosperma-type dimers  Cytotoxicity  MONOTERPENOID INDOLE ALKALOIDS  BISINDOLE ALKALOIDS  DIVERSE SKELETONS  A-I  CONOPHYLLINE  
Blocking ROR1 enhances the roles of erlotinib in lung adenocarcinoma cell lines 期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 3, 页码: 2977-2984
Authors:  Wang, Hui-Li;  Liu, Yan-Chun;  Long, Ming-Peng;  Zheng, Chuan;  Yang, Jia-Hui
View  |  Adobe PDF(667Kb)  |  Favorite  |  View/Download:58/12  |  Submit date:2019/11/07
receptor tyrosine kinase-like orphan receptor 1  lung adenocarcinoma  erlotinib resistance  AKT  mammalian target of rapamycin  small interfering RNA  
Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China 期刊论文
BMC CHEMISTRY, 2019, 卷号: 13, 页码: 12
Authors:  Gu, Ronghui;  Wang, Yuehu;  Wu, Shibiao;  Wang, Yeling;  Li, Ping;  Xu, Li;  Zhou, Yue;  Chen, Ze'e;  Kennelly, Edward J.;  Long, Chunlin
View  |  Adobe PDF(1972Kb)  |  Favorite  |  View/Download:61/11  |  Submit date:2019/07/29
Tirpitzia sinensis  Linaceae  Lignans  Inflammatory  NO inhibition  Pharmacological targets  Pharmacophore  In silico  
Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 7, 页码: 10
Authors:  Zhang, Yu;  Goto, Masuo;  Oda, Akifumi;  Hsu, Pei-Ling;  Guo, Ling-Li;  Fu, Yan-Hui;  Morris-Natschke, Susan L.;  Hamel, Ernest;  Lee, Kuo-Hsiung;  Hao, Xiao-Jiang
View  |  Adobe PDF(3129Kb)  |  Favorite  |  View/Download:79/12  |  Submit date:2019/07/29
aspidosperma-type  monoterpenoid indole alkaloids  antiproliferative activity  tubulin inhibitor  Bousigonia mekongensis  
Bisindole alkaloids from Tabernaemontana corymbosa 期刊论文
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2018, 卷号: 99, 期号: 0, 页码: 37-53
Authors:  Zhang, Bing-Jie;  Lu, Jing-Song;  Bao, Mei-Fen;  Zhong, Xiu-Hong;  Ni, Ling;  Wu, Jing;  Cai, Xiang-Hai
View  |  Adobe PDF(836Kb)  |  Favorite  |  View/Download:79/30  |  Submit date:2018/12/27
紫金龙等五种药用植物异喹啉和吲哚结构及生物活性研究 学位论文
: 中国科学院大学, 2017
Authors:  王蓓
Adobe PDF(5603Kb)  |  Favorite  |  View/Download:226/14  |  Submit date:2019/06/14
三种天然产物的结构修饰与生物活性研究 学位论文
: 中国科学院大学, 2017
Authors:  任健
Adobe PDF(19285Kb)  |  Favorite  |  View/Download:53/11  |  Submit date:2019/06/14
Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 9, 页码: 10203-10214
Authors:  Kong, Ling-Mei;  Feng, Tao;  Wang, Yuan-Yuan;  Li, Xing-Yao;  Ye, Zhen-Nan;  An, Tao;  Qing, Chen;  Luo, Xiao-Dong;  Li, Yan
View  |  Adobe PDF(7290Kb)  |  Favorite  |  View/Download:132/25  |  Submit date:2016/08/22
Bisleuconothine a  Inhibitor  Wnt Signaling  Colorectal Cancer Cells