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Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus
Deng,Zhen-Tao; Li,Wen-Yan; Wang,Lei; Zhou,Zhi-Ping; Wu,Xing-De; Ding,Zhong-Tao; Zhao,Qin-Shi
2021
Source PublicationMOLECULES
ISSN1420-3049
Volume26Issue:21Pages:6516
AbstractCatharanthus roseus is a well-known traditional herbal medicine for the treatment of cancer, hypertension, scald, and sore in China. Phytochemical investigation on the twigs and leaves of this species led to the isolation of two new monoterpene indole alkaloids, catharanosines A (1) and B (2), and six known analogues (3-8). Structures of 1 and 2 were established by H-1-, C-13- and 2D-NMR, and HREIMS data. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 2 represented an unprecedented aspidosperma-type alkaloid with a 2-piperidinyl moiety at C-10. Compounds 6-8 exhibited remarkable Ca(v)3.1 low voltage-gated calcium channel (LVGCC) inhibitory activity with IC50 values of 11.83 & PLUSMN; 1.02, 14.3 & PLUSMN; 1.20, and 14.54 & PLUSMN; 0.99 mu M, respectively.
KeywordCatharanthus roseus monoterpene indole alkaloid catharanosine A Ca(v)3 1 low voltage-gated calcium channel (LVGCC) VINCA ALKALOIDS CELL-PROLIFERATION N-OXIDE SARPAGINE BIOSYNTHESIS VINORELBINE VINBLASTINE MECHANISM ROOTS BASES
DOI10.3390/molecules26216516
WOS IDWOS:000719074500001
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/73717
Collection中国科学院昆明植物研究所
Affiliation1.[Deng, Zhen-Tao
2.Zhou, Zhi-Ping
3.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
4.Li, Wen-Yan
5.Wang, Lei
6.Wu, Xing-De
7.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
9.Yunnan Minzu Univ, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China
10.Yunnan Minzu Univ, Minist Educ, Kunming 650500, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Deng,Zhen-Tao,Li,Wen-Yan,Wang,Lei,et al. Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus[J]. MOLECULES,2021,26(21):6516.
APA Deng,Zhen-Tao.,Li,Wen-Yan.,Wang,Lei.,Zhou,Zhi-Ping.,Wu,Xing-De.,...&Zhao,Qin-Shi.(2021).Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus.MOLECULES,26(21),6516.
MLA Deng,Zhen-Tao,et al."Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus".MOLECULES 26.21(2021):6516.
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