Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus

doi:10.3390/molecules26216516

KIB OpenIR

	Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus
	Deng,Zhen-Tao ; Li,Wen-Yan ; Wang,Lei; Zhou,Zhi-Ping ; Wu,Xing-De ; Ding,Zhong-Tao ; Zhao,Qin-Shi
	2021
发表期刊	MOLECULES
ISSN	1420-3049
卷号	26 期号:21 页码:6516
摘要	Catharanthus roseus is a well-known traditional herbal medicine for the treatment of cancer, hypertension, scald, and sore in China. Phytochemical investigation on the twigs and leaves of this species led to the isolation of two new monoterpene indole alkaloids, catharanosines A (1) and B (2), and six known analogues (3-8). Structures of 1 and 2 were established by H-1-, C-13- and 2D-NMR, and HREIMS data. The absolute configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 2 represented an unprecedented aspidosperma-type alkaloid with a 2-piperidinyl moiety at C-10. Compounds 6-8 exhibited remarkable Ca(v)3.1 low voltage-gated calcium channel (LVGCC) inhibitory activity with IC50 values of 11.83 & PLUSMN; 1.02, 14.3 & PLUSMN; 1.20, and 14.54 & PLUSMN; 0.99 mu M, respectively.
关键词	Catharanthus roseus monoterpene indole alkaloid catharanosine A Ca(v)3 1 low voltage-gated calcium channel (LVGCC) VINCA ALKALOIDS CELL-PROLIFERATION N-OXIDE SARPAGINE BIOSYNTHESIS VINORELBINE VINBLASTINE MECHANISM ROOTS BASES
DOI	10.3390/molecules26216516
WOS记录号	WOS:000719074500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73717
专题	中国科学院昆明植物研究所
作者单位	1.[Deng, Zhen-Tao 2.Zhou, Zhi-Ping 3.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China 4.Li, Wen-Yan 5.Wang, Lei 6.Wu, Xing-De 7.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 9.Yunnan Minzu Univ, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China 10.Yunnan Minzu Univ, Minist Educ, Kunming 650500, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Deng,Zhen-Tao,Li,Wen-Yan,Wang,Lei,et al. Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus[J]. MOLECULES,2021,26(21):6516.
APA	Deng,Zhen-Tao.,Li,Wen-Yan.,Wang,Lei.,Zhou,Zhi-Ping.,Wu,Xing-De.,...&Zhao,Qin-Shi.(2021).Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus.MOLECULES,26(21),6516.
MLA	Deng,Zhen-Tao,et al."Monoterpene Indole Alkaloids with Ca(v)3.1 T-Type Calcium Channel Inhibitory Activity from Catharanthus roseus".MOLECULES 26.21(2021):6516.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
067-E15-226-邓振涛-M.pd（2354KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	浏览下载