A review on the relationship of mast cells and macrophages in breast cancer - Can herbs or natural products facilitate their anti-tumor effects?

doi:10.1016/j.phrs.2020.105321

KIB OpenIR

	A review on the relationship of mast cells and macrophages in breast cancer - Can herbs or natural products facilitate their anti-tumor effects?
	Gou,Leilei ; Yue,Grace Gar-Lee ; Puno,Pema Tenzin ; Lau,Clara Bik-San
	2021
Source Publication	PHARMACOLOGICAL RESEARCH
ISSN	1043-6618
Volume	164 Pages:105321
Abstract	Breast cancer is an inflammation-related cancer whose tumor microenvironment is largely infiltrated by inflammatory cells. These inflammatory cells including mast cells and macrophages have been elucidated to be vital participants in breast tumor proliferation, survival, invasion and migration. However, the functions of mast cells and macrophages in breast cancer are quite distinct based on recent data. Mast cells exhibit both anti-tumoral and pro-tumoral functions on breast cancer, while high number of tumor-associated macrophages (TAMs) are strongly correlated with poor prognosis and higher risk of distant metastasis in breast cancer patients. Besides, many natural products/extracts have been reported to regulate mast cells and macrophages. In this review, the roles of mast cells and macrophages play in breast cancer are discussed and a summary of those natural products/herbs regulating the functions of mast cells or macrophages is also presented.
Keyword	Breast cancer Mast cell Macrophage Natural products Herbs Extracts TUMOR-ASSOCIATED MACROPHAGES NF-KAPPA-B MEDIATED ALLERGIC REACTIONS PRO-INFLAMMATORY CYTOKINES ANTIINFLAMMATORY ACTIVITY ATOPIC-DERMATITIS UMBROSA ROOT TNF-ALPHA IN-VIVO C-KIT
DOI	10.1016/j.phrs.2020.105321
WOS ID	WOS:000615153300009
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73366
Collection	中国科学院昆明植物研究所
Affiliation	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hksar, Peoples R China 3.Chinese Univ Hong Kong, State Key Lab Res Bioact & Clin Applicat Med Plan, Shatin, Hksar, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation GB/T 7714	Gou,Leilei,Yue,Grace Gar-Lee,Puno,Pema Tenzin,et al. A review on the relationship of mast cells and macrophages in breast cancer - Can herbs or natural products facilitate their anti-tumor effects?[J]. PHARMACOLOGICAL RESEARCH,2021,164:105321.
APA	Gou,Leilei,Yue,Grace Gar-Lee,Puno,Pema Tenzin,&Lau,Clara Bik-San.(2021).A review on the relationship of mast cells and macrophages in breast cancer - Can herbs or natural products facilitate their anti-tumor effects?.PHARMACOLOGICAL RESEARCH,164,105321.
MLA	Gou,Leilei,et al."A review on the relationship of mast cells and macrophages in breast cancer - Can herbs or natural products facilitate their anti-tumor effects?".PHARMACOLOGICAL RESEARCH 164(2021):105321.

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