Trimeric and dimeric Aspidosperma-type alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'

doi:10.1016/j.bioorg.2021.105314

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	Trimeric and dimeric Aspidosperma-type alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'
	Chen,Jing ; Yu,Yang ; Wu,Jing ; Bao,Mei-Fen ; Kongkiatpaiboon,Sumet ; Schinnerl,Johann ; Cai,Xiang-Hai
	2021
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	116 页码:105314
摘要	Continued interest in bioactive monoterpenoid indole alkaloids and the purpose to explore the artificial cultivation influence on the chemical composition in the same plant species, 8 undescribed Aspidosperma-type alkaloids including two unprecedented trimers, taberdivarines A-B (1-2), and six new dimers, taberdivarines C-H (3-8), together with 9 known bisindoles were isolated from the leaves of Tabernaemontana divaricata 'Dwaft'. Notably, taberdivarines A and B were the first cases of Aspidosperma-Aspidosperma-Aspidosperma-type alkaloids with furan ring linkage patterns of the natural products. Their structures were elucidated by comprehensive spectroscopic analyse. Compounds 1-8 were screened for the cytotoxicity against three human cancer cell lines, SMMC-7721, HT-29 and A549. Among them, Compound 6 exhibited significant activity against three cell lines with IC50 values of 0.30, 0.75 and 3.41 mu M, respectively (IC50 = 3.02, 0.14 and 2.23 mu M for the positive control, vinorelbine). Compound 1, 3, 4, 6, 7 and 8 also expressed varying degrees of activity. The structure-activity relationships (SARs) of these alkaloids were discussed.
关键词	Tabernaemontana divaricata 'Dwaft' Monoterpenoid indole alkaloid Aspidosperma-type trimmers Aspidosperma-type dimers Cytotoxicity MONOTERPENOID INDOLE ALKALOIDS BISINDOLE ALKALOIDS DIVERSE SKELETONS A-I CONOPHYLLINE
DOI	10.1016/j.bioorg.2021.105314
WOS记录号	WOS:000701921100004
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/73773
专题	中国科学院昆明植物研究所
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Thammasat Univ, Off Adv Sci & Technol, Drug Discovery & Dev Ctr, Pathum Thani 12121, Thailand 4.Univ Vienna, Div Systemat & Evolutionary Bot, Chemodivers Res Grp, Rennweg 14, A-1030 Vienna, Austria
推荐引用方式 GB/T 7714	Chen,Jing,Yu,Yang,Wu,Jing,et al. Trimeric and dimeric Aspidosperma-type alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'[J]. BIOORGANIC CHEMISTRY,2021,116:105314.
APA	Chen,Jing.,Yu,Yang.,Wu,Jing.,Bao,Mei-Fen.,Kongkiatpaiboon,Sumet.,...&Cai,Xiang-Hai.(2021).Trimeric and dimeric Aspidosperma-type alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'.BIOORGANIC CHEMISTRY,116,105314.
MLA	Chen,Jing,et al."Trimeric and dimeric Aspidosperma-type alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'".BIOORGANIC CHEMISTRY 116(2021):105314.