Trimeric and dimeric Aspidosperma-type alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'

doi:10.1016/j.bioorg.2021.105314

KIB OpenIR

	Trimeric and dimeric Aspidosperma-type alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'
	Chen,Jing ; Yu,Yang ; Wu,Jing ; Bao,Mei-Fen ; Kongkiatpaiboon,Sumet ; Schinnerl,Johann ; Cai,Xiang-Hai
	2021
Source Publication	BIOORGANIC CHEMISTRY
ISSN	0045-2068
Volume	116 Pages:105314
Abstract	Continued interest in bioactive monoterpenoid indole alkaloids and the purpose to explore the artificial cultivation influence on the chemical composition in the same plant species, 8 undescribed Aspidosperma-type alkaloids including two unprecedented trimers, taberdivarines A-B (1-2), and six new dimers, taberdivarines C-H (3-8), together with 9 known bisindoles were isolated from the leaves of Tabernaemontana divaricata 'Dwaft'. Notably, taberdivarines A and B were the first cases of Aspidosperma-Aspidosperma-Aspidosperma-type alkaloids with furan ring linkage patterns of the natural products. Their structures were elucidated by comprehensive spectroscopic analyse. Compounds 1-8 were screened for the cytotoxicity against three human cancer cell lines, SMMC-7721, HT-29 and A549. Among them, Compound 6 exhibited significant activity against three cell lines with IC50 values of 0.30, 0.75 and 3.41 mu M, respectively (IC50 = 3.02, 0.14 and 2.23 mu M for the positive control, vinorelbine). Compound 1, 3, 4, 6, 7 and 8 also expressed varying degrees of activity. The structure-activity relationships (SARs) of these alkaloids were discussed.
Keyword	Tabernaemontana divaricata 'Dwaft' Monoterpenoid indole alkaloid Aspidosperma-type trimmers Aspidosperma-type dimers Cytotoxicity MONOTERPENOID INDOLE ALKALOIDS BISINDOLE ALKALOIDS DIVERSE SKELETONS A-I CONOPHYLLINE
DOI	10.1016/j.bioorg.2021.105314
WOS ID	WOS:000701921100004
Citation statistics
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/73773
Collection	中国科学院昆明植物研究所
Affiliation	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Thammasat Univ, Off Adv Sci & Technol, Drug Discovery & Dev Ctr, Pathum Thani 12121, Thailand 4.Univ Vienna, Div Systemat & Evolutionary Bot, Chemodivers Res Grp, Rennweg 14, A-1030 Vienna, Austria
Recommended Citation GB/T 7714	Chen,Jing,Yu,Yang,Wu,Jing,et al. Trimeric and dimeric Aspidosperma-type alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'[J]. BIOORGANIC CHEMISTRY,2021,116:105314.
APA	Chen,Jing.,Yu,Yang.,Wu,Jing.,Bao,Mei-Fen.,Kongkiatpaiboon,Sumet.,...&Cai,Xiang-Hai.(2021).Trimeric and dimeric Aspidosperma-type alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'.BIOORGANIC CHEMISTRY,116,105314.
MLA	Chen,Jing,et al."Trimeric and dimeric Aspidosperma-type alkaloids from leaves of Tabernaemontana divaricata 'Dwaft'".BIOORGANIC CHEMISTRY 116(2021):105314.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院昆明植物研究所知识管理系统