RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression

doi:10.3390/molecules24091829

	RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression
	Guo, Di 1; Wang, Yurong 1; Wang, Jing 1; Song, Lihua 1; Wang, Zhe1,2 ; Mao, Bingyu 3; Tan, Ninghua 1,2
通讯作者	Tan, Ninghua(nhtan@cpu.edu.cn)
	2019-05-01
发表期刊	MOLECULES
ISSN	1420-3049
卷号	24 期号:9 页码:14
摘要	Lipogenesis plays a critical role in the growth and metastasis of tumors, which is becoming an attractive target for anti-tumor drugs. RA-XII, one of the cyclopeptide glycosides isolated from Rubia yunnanensis, exerts anti-tumor effects on liver cancer. However, the underlying mechanisms are not clear. In the present study, the effects of RA-XII on lipogenesis were evaluated and the underlying mechanisms were investigated. The results indicated that RA-XII strongly inhibited tumor growth and lipogenesis (triglycerides and lipid droplets) in HepG2 cells, and the expression of key factors involved in lipogenesis (SREBP, SCD, FASN) was also obviously downregulated. Further investigation showed that the anti-tumor effects of RA-XII were attenuated by SREBP knockdown. Moreover, RA-XII downregulated the expression of SREBP cleavage-activating protein (SCAP), an upstream regulator of SREBP, and siRNA of SCAP prevented its restrained effects on tumor growth and lipogenesis. In addition, the in vivo experiment showed that RA-XII strongly restrained the lipogenesis and growth of liver tumor in nude mice xenograft model. Taken together, these results indicate that RA-XII suppresses the liver cancer growth by inhibition of lipogenesis via SCAP-dependent SREBP suppression. The findings reveal the potentials of RA-XII to be used in a novel therapeutic approach for treating liver cancer.
关键词	RA-XII lipogenesis SCAP SREBP liver cancer
DOI	10.3390/molecules24091829
收录类别	SCI
语种	英语
WOS记录号	WOS:000469518100188
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/67247
专题	植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Tan, Ninghua
作者单位	1.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept TCMs Pharmaceut, State Key Lab Nat Med, Nanjing 211198, Jiangsu, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Guo, Di,Wang, Yurong,Wang, Jing,et al. RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression[J]. MOLECULES,2019,24(9):14.
APA	Guo, Di.,Wang, Yurong.,Wang, Jing.,Song, Lihua.,Wang, Zhe.,...&Tan, Ninghua.(2019).RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression.MOLECULES,24(9),14.
MLA	Guo, Di,et al."RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression".MOLECULES 24.9(2019):14.

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