RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression
Guo, Di1; Wang, Yurong1; Wang, Jing1; Song, Lihua1; Wang, Zhe1,2; Mao, Bingyu3; Tan, Ninghua1,2
Corresponding AuthorTan, Ninghua(nhtan@cpu.edu.cn)
2019-05-01
Source PublicationMOLECULES
ISSN1420-3049
Volume24Issue:9Pages:14
AbstractLipogenesis plays a critical role in the growth and metastasis of tumors, which is becoming an attractive target for anti-tumor drugs. RA-XII, one of the cyclopeptide glycosides isolated from Rubia yunnanensis, exerts anti-tumor effects on liver cancer. However, the underlying mechanisms are not clear. In the present study, the effects of RA-XII on lipogenesis were evaluated and the underlying mechanisms were investigated. The results indicated that RA-XII strongly inhibited tumor growth and lipogenesis (triglycerides and lipid droplets) in HepG2 cells, and the expression of key factors involved in lipogenesis (SREBP, SCD, FASN) was also obviously downregulated. Further investigation showed that the anti-tumor effects of RA-XII were attenuated by SREBP knockdown. Moreover, RA-XII downregulated the expression of SREBP cleavage-activating protein (SCAP), an upstream regulator of SREBP, and siRNA of SCAP prevented its restrained effects on tumor growth and lipogenesis. In addition, the in vivo experiment showed that RA-XII strongly restrained the lipogenesis and growth of liver tumor in nude mice xenograft model. Taken together, these results indicate that RA-XII suppresses the liver cancer growth by inhibition of lipogenesis via SCAP-dependent SREBP suppression. The findings reveal the potentials of RA-XII to be used in a novel therapeutic approach for treating liver cancer.
KeywordRA-XII lipogenesis SCAP SREBP liver cancer
DOI10.3390/molecules24091829
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000469518100188
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/67247
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorTan, Ninghua
Affiliation1.China Pharmaceut Univ, Sch Tradit Chinese Pharm, Dept TCMs Pharmaceut, State Key Lab Nat Med, Nanjing 211198, Jiangsu, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China
Recommended Citation
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Guo, Di,Wang, Yurong,Wang, Jing,et al. RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression[J]. MOLECULES,2019,24(9):14.
APA Guo, Di.,Wang, Yurong.,Wang, Jing.,Song, Lihua.,Wang, Zhe.,...&Tan, Ninghua.(2019).RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression.MOLECULES,24(9),14.
MLA Guo, Di,et al."RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression".MOLECULES 24.9(2019):14.
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