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Discovery and bioinspired total syntheses of unprecedented sesquiterpenoid dimers unveiled bifurcating [4+2] cycloaddition and target differentiation of enantiomers 期刊论文
CHEMICAL SCIENCE, 2024, 卷号: 15, 期号: 4
Authors:  He, Tao-Bin;  Yan, Bing-Chao;  Zhou, Yuan-Fei;  Sang, Yue-Qian;  Li, Xiao-Nian;  Sun, Han-Dong;  Wang, Chu;  Xue, Xiao-Song;  Puno, Pema-Tenzin
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DIELS-ALDER REACTION  BIOMIMETIC SYNTHESES  EFFICIENT ACCESS  DEHYDROGENATION  CYCLOHEXANONES  BIOSYNTHESIS  CONVERSION  OXIDATION  DYNAMICS  PHENOLS  
Cyclobutane-Containing Meroditerpenoids, (+)-Isoscopariusins B and C: Structure Elucidation and Biomimetic Synthesis 期刊论文
ORGANIC LETTERS, 2023, 卷号: 25, 期号: 17, 页码: 2981-2985
Authors:  Li,Ming-Xiang;  Yan,Bing-Chao;  Zhou,Min;  Li,Xing-Ren;  Li,Xiao-nian;  He,Shi-Jun;  Sun,Han-Dong;  Puno,Pema-Tenzin
View  |  Adobe PDF(1928Kb)  |  Favorite  |  View/Download：91/11  |  Submit date：2024/07/10
2+2 PHOTOCYCLOADDITION REACTIONS  VISIBLE-LIGHT PHOTOCATALYSIS  LEWIS-ACID CATALYSIS  CYCLOADDITIONS  DERIVATIVES  
Discovery of Natural Potent HMG-CoA Reductase Degraders for Lowering Cholesterol 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023
Authors:  Su,Xiao-Zheng;  Zhang,Lin-Fei;  Hu,Kun;  An,Yang;  Zhang,Qiao-Peng;  Tang,Jian-Wei;  Yan,Bing-Chao;  Li,Xing-Ren;  Cai,Jie;  Li,Xiao-Nian;  Sun,Han-Dong;  Jiang,Shi-You;  Puno,Pema-Tenzin
View  |  Adobe PDF(7289Kb)  |  Favorite  |  View/Download：153/27  |  Submit date：2024/07/10
Enzymes  Meroterpenoids  Natural Products  Proteomics  Semisynthesis  STATIN  FUNGUS  RISK  ACID  
Phomopsischalins A-C, polycyclic-fused cytochalasins from the endophytic fungus Phomopsis sp. shj2 and their abilities to induce lysosomal function 期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2023, 卷号: 10, 期号: 9, 页码: 2218-2225
Authors:  Chen,Rong;  Guo,Li-Jing;  Li,Xue-Dan;  Li,Xing-Ren;  Hu,Kun;  Tang,Jian-Wei;  Ye,Zhen-Nan;  Yan,Bing-Chao;  Puno,Pema-Tenzin
View  |  Adobe PDF(1676Kb)  |  Favorite  |  View/Download：114/19  |  Submit date：2024/07/22
Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 135, 页码: 106512
Authors:  Tan,Qian;  Hu,Kun;  Li,Xiao-Nian;  Yang,Xing-Zhi;  Sun,Han-Dong;  Puno,Pema-Tenzin
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Isodon wardii  ent-Kauranoids  Cytotoxicity  Apoptosis  Cell cycle  
Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2023, 卷号: 210, 页码: 115491
Authors:  Gou,Leilei;  Yue,Grace Gar-Lee;  Lee,Julia Kin -Ming;  Puno,Pema Tenzin;  Lau,Clara Bik-San
Adobe PDF(16654Kb)  |  Favorite  |  View/Download：124/11  |  Submit date：2024/07/22
Breast cancer  Metastasis  Natural products  Eriocalyxin B  Cancer recurrence  Cancer stem cells  Gut microbiome  NF-KAPPA-B  STEM-CELLS  MOLECULAR-MECHANISMS  EXTRACELLULAR-MATRIX  TUMOR-GROWTH  APOPTOSIS  ANGIOGENESIS  PROGRESSION  CARCINOMA  LEUKEMIA  
Isoxerophilins A and B, two diterpene heterodimers from Isodon xerophilus: structural elucidation and semisynthesis of isoxerophilin analogues 期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2023, 卷号: 11, 期号: 1, 页码: 37-46
Authors:  Dai,Jia-Meng;  Yan,Bing-Chao;  Kong,Ling-Mei;  Hu,Kun;  Li,Xing-Ren;  Li,Xiao-Nian;  Sun,Han-Dong;  Li,Yan;  Puno,Pema-Tenzin
View  |  Adobe PDF(1181Kb)  |  Favorite  |  View/Download：160/14  |  Submit date：2024/05/09
ENT-KAURANE DITERPENOIDS  ABIETANE DITERPENOIDS  A-D  DIMERS  OXIDATION  CYCLOADDUCTS  ACTIVATION  LIGANDS  IBX  
Four new lanostane triterpenoids featuring extended pi-conjugated systems from the stems of Kadsura coccinea. 期刊论文
Natural products and bioprospecting, 2023, 卷号: 13, 期号: 1, 页码: 12-12
Authors:  Zhang, Qi-Qi;  Hu, Kun;  Sun, Han-Dong;  Puno, Pema-Tenzin
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Oligosaccharide analysis of the backbone structure of the characteristic polysaccharide of Dendrobium officinale 期刊论文
FOOD HYDROCOLLOIDS, 2023, 卷号: 134, 页码: 108038
Authors:  Wong, Tin-Long;  Li, Li-Feng;  Zhang, Ji-Xia;  Zhang, Quan-Wei;  Zhang, Xue-Ting;  Zhou, Li-Shuang;  Fung, Hau-Yee;  Feng, Lei;  Cheng, Hui -Yuan;  Huo, Chu-Ying;  Liu, Man;  Bao, Wan-Rong;  Wu, Wen-Jie;  Lai, Cheuk-Hei;  Bai, Su -Ping;  Nie, Shao-Ping;  Puno, Pema-Tenzin;  Lau, Clara Bik-San;  Leung, Ping -Chung;  Han, Quan-Bin;  Sun, Han-Dong
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Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities 期刊论文
JOURNAL OF FUNGI, 2022, 卷号: 8, 期号: 5, 页码: 543
Authors:  Yan, Bing-Chao;  Wang, Wei-Guang;  Kong, Ling-Mei;  Tang, Jian-Wei;  Du, Xue;  Li, Yan;  Puno, Pema-Tenzin
View  |  Adobe PDF(1464Kb)  |  Favorite  |  View/Download：173/35  |  Submit date：2024/04/30
endophytic fungus  Phomopsis  cytochalasan  antimigratory activity  DERIVATIVES