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| Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii | |
Tan,Qian; Hu,Kun ; Li,Xiao-Nian; Yang,Xing-Zhi; Sun,Han-Dong; Puno,Pema-Tenzin
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| 2023 | |
| Source Publication | BIOORGANIC CHEMISTRY
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| ISSN | 1090-2120 |
| Volume | 135Pages:106512 |
| Abstract | Twenty new ent-kaurane diterpenoids, wardiisins A-T (1-20), along with two previously undescribed artefactual compounds (21 and 22) and twelve known analogues (23-34), were isolated from the aerial part of Isodon wardii. Their structures were elucidated by comprehensive analysis of spectroscopic data and single-crystal X-ray diffraction, and most of them were found to bear unusual C-12 oxygenation. Compounds 4, 7, 8, 19, 20, 21 exhibited remarkable cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MDA-MB-231, and SW480, with IC50 values ranging from 0.3 to 5.2 mu M. Moreover, 7 was found to induce G2/M cell cycle arrest and promote apoptosis in SW480 cell lines. |
| Keyword | Isodon wardii ent-Kauranoids Cytotoxicity Apoptosis Cell cycle |
| Subject Area | Biochemistry & Molecular Biology ; Chemistry |
| DOI | 10.1016/j.bioorg.2023.106512 |
| Indexed By | SCI |
| WOS ID | WOS:000977905800001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.kib.ac.cn/handle/151853/75477 |
| Collection | 中国科学院昆明植物研究所 |
| Recommended Citation GB/T 7714 | Tan,Qian,Hu,Kun,Li,Xiao-Nian,et al. Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii[J]. BIOORGANIC CHEMISTRY,2023,135:106512. |
| APA | Tan,Qian,Hu,Kun,Li,Xiao-Nian,Yang,Xing-Zhi,Sun,Han-Dong,&Puno,Pema-Tenzin.(2023).Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii.BIOORGANIC CHEMISTRY,135,106512. |
| MLA | Tan,Qian,et al."Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii".BIOORGANIC CHEMISTRY 135(2023):106512. |
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| 1-s2.0-S004520682300（3171KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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