Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii

doi:10.1016/j.bioorg.2023.106512

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	Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii
	Tan,Qian; Hu,Kun; Li,Xiao-Nian; Yang,Xing-Zhi; Sun,Han-Dong; Puno,Pema-Tenzin
	2023
发表期刊	BIOORGANIC CHEMISTRY
ISSN	1090-2120
卷号	135 页码:106512
摘要	Twenty new ent-kaurane diterpenoids, wardiisins A-T (1-20), along with two previously undescribed artefactual compounds (21 and 22) and twelve known analogues (23-34), were isolated from the aerial part of Isodon wardii. Their structures were elucidated by comprehensive analysis of spectroscopic data and single-crystal X-ray diffraction, and most of them were found to bear unusual C-12 oxygenation. Compounds 4, 7, 8, 19, 20, 21 exhibited remarkable cytotoxicity against the cancer cell lines HL-60, SMMC-7721, A-549, MDA-MB-231, and SW480, with IC50 values ranging from 0.3 to 5.2 mu M. Moreover, 7 was found to induce G2/M cell cycle arrest and promote apoptosis in SW480 cell lines.
关键词	Isodon wardii ent-Kauranoids Cytotoxicity Apoptosis Cell cycle
学科领域	Biochemistry & Molecular Biology ; Chemistry
DOI	10.1016/j.bioorg.2023.106512
收录类别	SCI
WOS记录号	WOS:000977905800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75477
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Tan,Qian,Hu,Kun,Li,Xiao-Nian,et al. Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii[J]. BIOORGANIC CHEMISTRY,2023,135:106512.
APA	Tan,Qian,Hu,Kun,Li,Xiao-Nian,Yang,Xing-Zhi,Sun,Han-Dong,&Puno,Pema-Tenzin.(2023).Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii.BIOORGANIC CHEMISTRY,135,106512.
MLA	Tan,Qian,et al."Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii".BIOORGANIC CHEMISTRY 135(2023):106512.

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