Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo

doi:10.1016/j.bcp.2023.115491

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	Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo
	Gou,Leilei; Yue,Grace Gar-Lee; Lee,Julia Kin -Ming; Puno,Pema Tenzin; Lau,Clara Bik-San
	2023
发表期刊	BIOCHEMICAL PHARMACOLOGY
ISSN	1873-2968
卷号	210 页码:115491
摘要	Breast cancer is the most commonly diagnosed cancer among women, and its metastasis to distant organs accounts for the majority of death. Eriocalyxin B (Eri B), an ent-kaurane diterpenoid isolating from Isodon eriocalyx var. laxiflora, has previously been reported to have anti-tumor and anti-angiogenic effects in breast cancer. Here, we investigated the effect of Eri B on cell migration and adhesion in triple negative breast cancer (TNBC) cells, as well as aldehyde dehydrogenases 1 family member A1 (ALDH1A1) expression, colony- and sphere-formation in cancer stem cell (CSC) enriched MDA-MB-231 cells. The in vivo anti-metastatic activities of Eri B were determined in 3 different breast tumor-bearing mouse models. Our results indicated that Eri B inhibited TNBC cell migration and adhesion to extracellular matrix proteins, and also reduced ALDH1A1 expression and colony formation in CSC-enriched MDA-MB-231 cells. The metastasis-related pathways, such as epidermal growth factor receptor/ mitogen-activated protein kinase kinases 1/2/ extracellular regulated protein kinase signaling altered by Eri B was firstly shown in MDA-MB-231 cells. The potent anti-metastatic efficacies of Eri B were demonstrated in breast xenograft-bearing mice and syngeneic breast tumor-bearing mice. Gut microbiome analysis results revealed the change in the diversity and composition of microbiome after Eri B treatment, and the potential pathways that are involved in the anti-cancer efficacy of Eri B. In conclusion, Eri B was shown to inhibit breast cancer metastasis in both in vitro and in vivo models. Our findings further support the development of Eri B as an anti-metastatic agent for breast cancer.
关键词	Breast cancer Metastasis Natural products Eriocalyxin B Cancer recurrence Cancer stem cells Gut microbiome NF-KAPPA-B STEM-CELLS MOLECULAR-MECHANISMS EXTRACELLULAR-MATRIX TUMOR-GROWTH APOPTOSIS ANGIOGENESIS PROGRESSION CARCINOMA LEUKEMIA
学科领域	Pharmacology & Pharmacy
DOI	10.1016/j.bcp.2023.115491
收录类别	SCI
WOS记录号	WOS:000995140000001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/75481
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Gou,Leilei,Yue,Grace Gar-Lee,Lee,Julia Kin -Ming,et al. Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo[J]. BIOCHEMICAL PHARMACOLOGY,2023,210:115491.
APA	Gou,Leilei,Yue,Grace Gar-Lee,Lee,Julia Kin -Ming,Puno,Pema Tenzin,&Lau,Clara Bik-San.(2023).Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo.BIOCHEMICAL PHARMACOLOGY,210,115491.
MLA	Gou,Leilei,et al."Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo".BIOCHEMICAL PHARMACOLOGY 210(2023):115491.

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