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High throughput-screening of native herbal compounds identifies taccaoside A as a cytotoxic compound that mediates RAS signaling in cancer stem cells 期刊论文
PHYTOMEDICINE, 2023, 卷号: 108, 页码: 154492
作者:  Yang,Dong;  Dai,Zhi;  Zhu,Peifeng;  Wang,Gan;  Sun,Bin;  Li,Shirong;  Hao,Junjun;  Wang,Yifen;  Liu,Yaping;  Yu,Shuaishuai;  Lai,Ren;  Luo,Xiao-Dong;  Zhao,Xudong
浏览  |  Adobe PDF(6987Kb)  |  收藏  |  浏览/下载：10/2  |  提交时间：2024/07/17
Natural product  Furostanol saponin  Taccaoside A  Cancer stem cell  RAS  STEROIDAL SAPONINS  NATURAL-PRODUCTS  PI3K/AKT  PROLIFERATION  MAINTENANCE  STATISTICS  MAPK/ERK  
Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 106268
作者:  Ma,Wen-Yi;  Xie,Jing;  Yu,Ling-Ling;  Zhang,Shi-Juan;  Ni,Wei;  Yan,Huan;  Liu,Hai-Yang
浏览  |  Adobe PDF(2307Kb)  |  收藏  |  浏览/下载：17/4  |  提交时间：2024/07/22
Ypsilandra thibetica  Steroidal saponins  Ypsilandrosides Z1-Z14  Hemostatic activity  Structure-activity relationship  SPIROSTANE GLYCOSIDES  NMR-SPECTROSCOPY  AGGREGATION  SAPOGENINS  SAPONINS  
Unraveling the serial glycosylation in the biosynthesis of steroidal saponins in the medicinal plant Paris polyphylla and their antifungal action 期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 11, 页码: 4638-4654
作者:  Chen,Yuegui;  Yan,Qin;  Ji,Yunheng;  Bai,Xue;  Li,Desen;  Mu,Rongfang;  Guo,Kai;  Yang,Minjie;  Tao,Yang;  Gershenzon,Jonathan;  Liu,Yan;  Li,Shenghong
浏览  |  Adobe PDF(2988Kb)  |  收藏  |  浏览/下载：52/13  |  提交时间：2024/05/09
Paris polyphylla var. yunnanensis  Steroidal saponins  Glycosyltransferases  Sugar chain elongation  Antifungal activity  CHEMICAL-CONSTITUENTS  GLYCOSYLTRANSFERASES  GLYCOSIDES  DIVERSITY  CULTIVATION  PATHWAY  FAMILY  PARTS  GENUS  STEP  
Cytotoxic and pro-apoptotic effects of botanical drugs derived from the indigenous cultivated medicinal plant Paris polyphylla var. yunnanensis 期刊论文
FRONTIERS IN PHARMACOLOGY, 2023, 卷号: 14, 页码: 1100825
作者:  Yan,Xiu-Xiang;  Zhao,Yan-Qiang;  He,Yun;  Disayathanoowat,Terd;  Pandith,Hataichanok;  Inta,Angkhana;  Yang,Li-Xin
浏览  |  Adobe PDF(3195Kb)  |  收藏  |  浏览/下载：29/5  |  提交时间：2024/05/09
Paris polyphylla var  yunnanensis  indigenous medicine knowledge  saponins  cytotoxic effects  pro-apoptotic effects  CELL-CYCLE ARREST  STEROIDAL SAPONINS  HEPATOCELLULAR-CARCINOMA  CHEMICAL-CONSTITUENTS  ASSAY  GLYCOSIDES  LEAVES  GROWTH  STEMS  SITES  
Isolation, structural elucidation, and bioactivity of cholestane derivatives from Ypsilandra thibetica 期刊论文
NEW JOURNAL OF CHEMISTRY, 2022, 卷号: 47, 期号: 1, 页码: 324-332
作者:  Xie, Jing;  Zhang, Shi-Juan;  Yue, Grace Gar-Lee;  Yu, Ling-Ling;  Liu, Hui;  Ma, Wen-Yi;  Yan, Huan;  Ni, Wei;  Lau, Clara Bik-San;  Liu, Hai-Yang
浏览  |  Adobe PDF(1693Kb)  |  收藏  |  浏览/下载：41/10  |  提交时间：2024/04/30
SPIROSTANE GLYCOSIDES  STEROIDAL SAPONINS  GROWTH  
Cloning and Functional Characterization of a Squalene Synthase from Paris polyphylla var. yunnanensis 期刊论文
CHEMISTRY & BIODIVERSITY, 2021, 卷号: 18, 期号: 7
作者:  Gao,Jian-Xiong;  Chen,Yue-Gui;  Li,De-Sen;  Lin,Liang;  Liu,Yan;  Li,Sheng-Hong
浏览  |  Adobe PDF(5087Kb)  |  收藏  |  浏览/下载：161/40  |  提交时间：2022/04/02
Paris polyphylla var  Yunnanensis  squalene synthase  steroidal saponins  squalene  in vitro enzymatic assay  MOLECULAR-CLONING  SAPONINS  EXPRESSION  GENE  GLYCOSIDES  PLANTS  SQS  
Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 210, 页码: 113068
作者:  Dai,Zhi;  Liu,Hui;  Wang,Bei;  Yang,Dong;  Zhu,Yan-Yan;  Yan,Huan;  Zhu,Pei-Feng;  Liu,Ya-Ping;  Chen,Hui-Cheng;  Zhao,Yun-li;  Zhao,Li-Xing;  Zhao,Xu-Dong;  Liu,Hai-Yang;  Luo,Xiao-Dong
浏览  |  Adobe PDF(2630Kb)  |  收藏  |  浏览/下载：173/89  |  提交时间：2022/04/02
Steroidal saponins  Structure-activity relationship  Tribulosaponin A  Glioma stem cells  ROS  SMALL MOLECULES  CARDIAC-ARREST  STEM-CELL  IDENTIFICATION  THERAPY  BRAIN  OPPORTUNITIES  GLIOMA  TUMORS  NOX2  
Transcriptome analyses of Paris polyphylla var. chinensis, Ypsilandra thibetica, and Polygonatum kingianum characterize their steroidal saponin biosynthesis pathway 期刊论文
FITOTERAPIA, 2019, 卷号: 135, 页码: 52-63
作者:  Yang, Zhenyan;  Yang, Lifang;  Liu, Changkun;  Qin, Xujie;  Liu, Haiyang;  Chen, Jiahui;  Ji, Yunheng
浏览  |  Adobe PDF(5111Kb)  |  收藏  |  浏览/下载：177/20  |  提交时间：2019/07/29
Steroidal saponins  Biosynthesis  Transcriptome  Monocotyledons  Cholesterol  Cycloartenol pathway  
Seeing the light: Shifting from wild rhizomes to extraction of active ingredients from above-ground parts of Paris polyphylla var. yunnanensis 期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2018, 卷号: 224, 期号: 1, 页码: 134-139
作者:  Qin, Xu-Jie;  Ni, Wei;  Chen, Chang-Xiang;  Liu, Hai-Yang
浏览  |  Adobe PDF(944Kb)  |  收藏  |  浏览/下载：300/91  |  提交时间：2018/09/27
Paris Polyphylla Var. Yunnanensis  Rhizoma Paridis  Steroidal Saponins  Sustainable Utilization  
Cytotoxic steroidal saponins from Trillium kamtschaticum 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 页码: 2267-2273
作者:  Qin, Xu-Jie;  Si, Yong-Ai;  Chen, Yu;  Liu, Hui;  Ni, Wei;  Yan, Huan;  Shu, Tong;  Ji, Yun-Heng;  Liu, Hai-Yang
浏览  |  Adobe PDF(529Kb)  |  收藏  |  浏览/下载：255/60  |  提交时间：2017/07/18
Trillium Kamtschaticum  Liliaceae  Steroidal Saponins  Cytotoxicity